Mesenchymal Cell News Volume 12.45 | Nov 17 2020

May 12, 2022

2020-17-11 | MESCN 12.45

Mesenchymal Cell News by STEMCELL Technologies

Vol. 12.45 – 17 November, 2020

TOP STORY

XPC
Deficiency Increases Risk of Hematologic Malignancies through Mutator Phenotype and Characteristic Mutational Signature

The authors analyzed a unique collection of internal Xeroderma Pigmentosum group C (XP-C) tumor genomes including six leukemias and two sarcomas. They observed a specific mutational pattern and an average of 25-fold increase of mutation rates in XP-C versus sporadic leukemia which they presumed led to its elevated incidence and early appearance.
[Nature Communications]

Full Article

Webinar: Bone Marrow Skeletal Progenitors and Bone Diseases

PUBLICATIONSRanked by the impact factor of the journal

IN VITRO

HDAC6 Promotes Growth, Migration/Invasion, and Self-Renewal of Rhabdomyosarcoma

Scientists used functional assays in vitro and in vitro (zebrafish and xenograft mouse models) to demonstrate the crucial role of HDAC6, a cytoplasmic histone deacetylase, in driving rhabdomyosarcoma tumor growth, self-renewal, and migration/invasion.
[Oncogene]

Abstract

The
Translational Repressor 4E-BP1 Regulates RRM2 Levels and Functions as a Tumor Suppressor in Ewing Sarcoma Tumors

Investigators showed that the expression of the RRM2 protein is dependent on active protein synthesis and that 4E-BP1, a repressor of cap-dependent protein translation, specifically regulates the level of the ribonucleotide reductase (RRM2) protein.
[Oncogene]

Abstract

GARP
Promotes the Proliferation and Therapeutic Resistance of Bone Sarcoma Cancer Cells through the Activation of TGF-β

Silencing of GARP in bone sarcoma cell lines blocked their proliferation and induced apoptosis. In contrast, overexpression of GARP promoted their growth in vitro and in vivo and increased their resistance to DNA damage and cell death induced by etoposide, doxorubicin, and irradiation.
[Cell Death & Disease]

Full Article

Vasculogenesis
from Human Dental Pulp Stem Cells Grown in Matrigel with Fully Defined Serum-Free Culture Media

Investigators designed and tested new endothelial differentiation media with a fully defined composition using standard basal culture media supplemented with a mixture of B27, heparin and growth factors, including VEGF-A165 at different concentrations.
[Biomedicines]

Full Article Graphical Abstract

Neurotrophic Effects of Dental Pulp Stem Cells on Trigeminal Neuronal Cells

Scientists investigated the trophic potential of dental pulp stem cells-derived conditioned medium to protect and regenerate isolated primary trigeminal ganglion neuronal cells.
[Scientific Reports]

Full Article

IN VIVO

Growth
Differentiation Factor 6, A Repressive Target of EZH2, Promotes the Commitment of Human Embryonic Stem Cells to Mesenchymal Stem Cells

An epigenome-wide analysis of human embryonic stem cells (hESCs) and MSCs revealed that growth differentiation factor 6, which is involved in bone formation, was the most upregulated gene associated with MSCs compared to hESCs.
[Bone Research]

Full Article

Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape

Systematic evaluation showed a highly diverse and dynamic landscape for the human vascular mesenchymal cell population that is not captured by the classic nomenclature. Observations stressed the need for a consensus multiparameter subclass designation along the lines of the cluster of differentiation classification for leucocytes.
[Journal of the American Heart Association]

Full Article

Low-Intensity
Ultrasound Combined with Allogenic Adipose-Derived Mesenchymal Stem Cells (AdMSCs) in Radiation-Induced Skin Injury Treatment

The improvement of allogeneic AdMSCs culture conditions with sonication in the acoustic cavitation threshold caused a significant decrease in wound healing. Histologically, the sonicated AdMSCs migrated to the area of skin lesions and directly participated in healing.
[Scientific Reports]

Full Article

The
Effect of Vascular Complications of Diabetes Mellitus on Human Umbilical Cord Tissue and the Number of Wharton Jelly’s Mesenchymal Stem Cells

The umbilical cords were investigated by the histomorphological method and the number of Wharton’s jelly (WJ)-MSC were detected by flow-cytometry using the CD90, CD44, CD105, and CD73 markers in WJ isolated from fresh umbilical cords.
[Molecular Biology Reports]

Abstract

Virtual Conference Exhibition: Pluripotent Stem Cells

REVIEWS

Lung
Multipotent Stem Cells of Mesenchymal Nature: Cellular Basis, Clinical Relevance and Implications for Stem Cell Therapy

The authors focus on the central role of lung-resident MSCs, which are closely associated with the pulmonary vasculature, in a variety of chronic and acute lung diseases.
[Antioxidants & Redox Signaling]

Abstract

Influences
of Xeno-Free Media on Mesenchymal Stem Cell Expansion for Clinical Application

Xeno-free media showed potential for safe use for human clinical treatment. However, the influences of these xeno-free media on MSCs are various and any xeno-free medium should be examined prior to being used for MSC cultures.
[Tissue Engineering and Regenerative Medicine]

Abstract

INDUSTRY AND POLICY NEWS

Second
Interim Analysis of Clinical Outcomes After 135 Patients Results in Recommendation to Continue Remestemcel-L Phase III Trial in COVID-19 ARDS

Mesoblast Limited announced that the randomized controlled Phase III trial of remestemcel-L in patients with moderate to severe acute respiratory distress syndrome (ARDS) due to COVID-19 infection had received a recommendation to continue from the independent Data Safety Monitoring Board following completion of the trial’s second interim analysis.
[Mesoblast Limited]

Press Release

Phase
III Osteoarthritis Clinical Trial Commences

Cynata Therapeutics Limited announced that the Phase III SCUlpTOR Trial of CYP-004, Cynata’s Cymerus™ MSC product for osteoarthritis, has now commenced.
[Cynata Therapeutics Limited (Globenewswire, Inc.)]

Press Release

FEATURED EVENT

XPC
Deficiency Increases Risk of Hematologic Malignancies through Mutator Phenotype and Characteristic Mutational Signature

HDAC6 Promotes Growth, Migration/Invasion, and Self-Renewal of Rhabdomyosarcoma

The
Translational Repressor 4E-BP1 Regulates RRM2 Levels and Functions as a Tumor Suppressor in Ewing Sarcoma Tumors

GARP
Promotes the Proliferation and Therapeutic Resistance of Bone Sarcoma Cancer Cells through the Activation of TGF-β

Vasculogenesis
from Human Dental Pulp Stem Cells Grown in Matrigel with Fully Defined Serum-Free Culture Media

Neurotrophic Effects of Dental Pulp Stem Cells on Trigeminal Neuronal Cells

Growth
Differentiation Factor 6, A Repressive Target of EZH2, Promotes the Commitment of Human Embryonic Stem Cells to Mesenchymal Stem Cells

Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape

Low-Intensity
Ultrasound Combined with Allogenic Adipose-Derived Mesenchymal Stem Cells (AdMSCs) in Radiation-Induced Skin Injury Treatment

The
Effect of Vascular Complications of Diabetes Mellitus on Human Umbilical Cord Tissue and the Number of Wharton Jelly’s Mesenchymal Stem Cells

Lung
Multipotent Stem Cells of Mesenchymal Nature: Cellular Basis, Clinical Relevance and Implications for Stem Cell Therapy

Influences
of Xeno-Free Media on Mesenchymal Stem Cell Expansion for Clinical Application

Second
Interim Analysis of Clinical Outcomes After 135 Patients Results in Recommendation to Continue Remestemcel-L Phase III Trial in COVID-19 ARDS

Phase
III Osteoarthritis Clinical Trial Commences

Sarcomas

> See All Events

Research Professional – Life Sciences

Postdoctoral
Fellow – Osteoarthritis

Postdoctoral
Scientists – Stem Cell Factors in Epithelial Cancers

Postdoctoral Positions – Stem Cells, Immunology, Biochemistry/Molecular Biology, Pathogenic Microbiology

Staff
Scientist – Heart Disease Molecular Mechanisms

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