 | | Vol. 12.47 – 1 December, 2020 |
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| Investigators reprogrammed human synovial fluid‐derived MSCs into induced pluripotent stem cells (iPSCs) using six reprogramming factors and reverted the iPSCs back to MSCs, as an approach to cell rejuvenation.
[Stem Cells] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers evaluated the regenerative potential of the murine pancreas post-human telomerase reverse transcriptase (hTERT)-MSC administration through the intrapancreatic and intravenous route. Both routes of hTERT-MSC transplantation increased the incorporation of BrdU by pancreatic β-cells compared to the control.
[Current Stem Cell Research & Therapy] |
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| The authors illustrated that canine dental pulp stem cells contained superior osteogenicity comparing with canine bone marrow-derived MSCs regarding alkaline phosphatase activity, matrix mineralization, and osteogenic marker expression.
[Scientific Reports] |
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| Researchers developed transplantable hyaline-like cartilage constructs by stimulating MSC chondrogenic differentiation as cell sheets.
[Scientific Reports] |
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| Human CD24–/CD44+ breast cancer stem cells (BCSCs) were treated with andrographolide in vitro for 24 hours. The cytotoxic effect of andrographolide on BCSCs was compared to that on human MSCs.
[PLoS One] |
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| While both acute low-intensity vibrations and lysophosphohaditic acid treatments increased nuclear YAP entry by 50 and 87% over the basal levels in simulated microgravity(SMG)-treated MSCs, nuclear YAP levels of all SMG groups were significantly lower than non-SMG controls.
[npj Microgravity] |
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| Efforts have been made to control MSC behavior by using material systems to engineer synthetic ECMs and/or include soluble factors in the media. Scientists propose a simple approach based on ion transporter stimulation to determine stem cell fate that avoids the use of growth factors.
[Communications Biology] |
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| Blood and ovary tissue were collected and analyzed after various placenta-derived (PD)-MSC transplantation treatments in an ovariectomized rat model. Changes in the expression of folliculogenesis- and ovary regeneration-related genes induced by PD-MSC treatments were analyzed by qRT-PCR, Western blotting, and histological analysis.
[Stem Cell Research & Therapy] |
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| Researchers conducted a small sample, single arm, pilot trial. In addition to standard therapy, they performed four rounds of transplantation of umbilical cell‐MSCs in 16 patients with severe and critically severe COVID‐19.
[Cell Proliferation] |
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| Investigators evaluated the potential role of macrophage-derived small extracellular vesicles (sEVs) in biomimetic mineralized collagen-mediated endogenous bone regeneration in vivo and in vitro. Macrophage-derived sEVs were involved in intrafibrillarly mineralized collagen (IMC)-mediated endogenous bone regeneration in vivo, and IMC-sEVs facilitated MSC osteogenesis through the Smad/1/5/9 pathway.
[International Journal of Oral Science] |
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| Drug release characteristics of a core-shell fibrous scaffold were assessed using methylene blue as a model drug. Penicillin/streptomycin-loaded substrates were used to test the effectiveness of the drug release against gram-positive and -negative bacterial strains. Finally, biocompatibility of the drug loaded platform was assessed using bone marrow-derived MSCs and NIH 3T3 cells.
[Scientific Reports] |
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| Scientists retrospectively analyzed the efficacy and safety of first-line eribulin therapy for patients with advanced soft tissue sarcoma, unable to receive doxorubicin. Six of 28 patients who received eribulin as any line treatment received eribulin as a first-line treatment.
[Scientific Reports] |
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| The authors discuss the transformative experimental strategies that are being leveraged to dissect the key cellular and molecular mechanisms that regulate fibrosis, and the translational approaches that are enabling the emergence of precision medicine-based therapies for patients with fibrosis.
[Nature] |
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| Recent developments in inorganic nanocomposite hydrogels for bone tissue engineering that are of vital importance but have not yet been comprehensively reviewed are summarized.
[iScience] |
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| To mark the end of Diabetes Awareness Month, Sonia Sidhu, Member of Parliament for Brampton South, on behalf of the Honourable Patty Hajdu, Minister of Health, announced an investment of $6 million through the CIHR-JDRF Partnership to Defeat Diabetes for two Canadian research teams to accelerate the development of stem cell-based therapies for the treatment of type 1 diabetes.
[Juvenile Diabetes Research Foundation] |
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| Calidi Biotherapeutics, Inc. announced that it has been granted a new patent from the European Patent Office (EPO). “Combination Immunotherapy Approach for Treatment of Cancer,” secures Calidi’s proprietary technology platform, Supernova 1, composed of the oncolytic agent, CAL1 vaccinia virus, loaded into allogeneic, adipose-derived MSCs.
[Calidi Biotherapeutics, Inc.] |
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| April 9 – April 14, 2021
Virtual |
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| | University of Illinois at Chicago College of Medicine – Chicago, Illinois, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Stanford University – Stanford, California, United States |
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| | Sanford Research – Sioux Falls, South Dakota, United States |
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| | Zhejiang University-University of Edinburgh Institute – Haining, China |
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