 | | Vol. 13.07 – 23 February, 2021 |
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| Scientists conducted a systematic assessment of the role of complement activation and effector pathways in sarcomas. Mice showed reduced susceptibility to 3-methylcholanthrene sarcomagenesis and transplanted sarcomas, whereas C1q and factor B deficiency had marginal effects.
[Nature Cancer] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers specifically depleted H3K36me2 or H3K36me3 in mesenchymal cells, using CRISPR-Cas9 to separately knock out the corresponding methyltransferases NSD1/2 or SETD2.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators showed that GBP5 was highly expressed in glioblastoma cell lines and in clinical samples, especially in the mesenchymal subtype.
[Cell Death & Disease] |
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| Biological functions of Elavl1 during osteogenic differentiation of bone marrow derived MSCs (BMSCs) is not well-understood. The authors report that specific knockdown of nuclear localized Elavl1 by RNA interference in multipotent BMSCs led to increased osteogenic differentiation.
[Frontiers in Cell and Developmental Biology] |
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| Scientists investigated the effects of high glucose on the innate immunity of podocytes and diabetic nephropathy mice via Toll like receptor (TLR) signaling, and explored the protective effects of human umbilical cord-MSCs on this process.
[Diabetes Research and Clinical Practice] |
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| The effects of circATRNL1 (hsa_circ_0020093) on the differentiation of bone marrow MSCs into chondrocytes were investigated.
[Archives of Medical Research] |
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| Researchers investigated the therapeutic effects of Moringa oleifera leaf extracts on osteogenic induction of rat bone marrow MSCs following peroxidative damage and to explore the underlying mechanisms.
[Journal of Orthopaedic Surgery and Research] |
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| In a preclinical model of orthopedic trauma, scientists demonstrated that distinct systemic immune profiles were correlated with impaired bone regeneration. Most notably, elevated blood levels of myeloid-derived suppressor cells and the immunosuppressive cytokine interleukin-10 were negatively correlated with functional bone regeneration as early as 1 week post-treatment.
[Proceedings of the National Academy of Sciences of the United States of America] |
| | The BMP signaling pathway is widely regarded as one of the most important pathways in vertebrate skeletal biology, of which BMP2 is a potent inducer, governing the osteoblast differentiation of bone marrow stromal cells. Researchers used RNA-seq, ATAC-seq, and animal models to characterize the BMP2-dependent gene regulatory network governing osteoblast lineage commitment.
[Cell Death & Disease] |
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| Investigators suggested that tumor stiffness could be at the crossroad of three major processes, i.e. matrix remodeling, MEK activation and stromal metabolic switch that might explain at least in part Mesenchymal high-grade serous ovarian cancers aggressiveness.
[Scientific Reports] |
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| The authors find out what scientific evidence is available on the use of autologous plasma concentrates and MSCs as complementary therapies at the management of Medication-related Osteonecrosis of the jaw.
[Journal of Stomatology, Oral and Maxillofacial Surgery] |
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| Mesoblast Limited has treated the first two children with their MSC product candidate remestemcel-L for life-threatening MIS-C associated with COVID-19. MIS-C, a potentially life-threatening inflammatory condition which involves multiple critical organs and their vasculature, is associated with prior rather than active COVID-19 infection.
[Mesoblast, Ltd.] |
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| June 9 – 17, 2021
Virtual |
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| | National University of Ireland Galway – Galway, Ireland |
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| | Portland VA Research Foundation – Portland, Oregon, United States |
| | | University of Southern Denmark – Odense M, Denmark |
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| | Karolinska Institutet – Flemingsberg, Sweden |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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