Mesenchymal Cell News Volume 13.08 | Mar 2 2021

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    Justin.choi
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    2021-03-02 | MESCN 13.08


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 13.08 – 2 March, 2021
    TOP STORY

    The Use of Nanovibration to Discover Specific and Potent Bioactive Metabolites that Stimulate Osteogenic Differentiation in Mesenchymal Stem Cells

    The authors used nanovibrational stimulation to induce osteogenic differentiation of MSCs, in the absence of off-target, nonosteogenic differentiation.
    [Science Advances]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Lymph Node Metastasis-Derived Gastric Cancer Cells Educate Bone Marrow-Derived Mesenchymal Stem Cells via YAP Signaling Activation by Exosomal Wnt5a

    Researchers found that lymph node metastasis (LNM)-gastric cancer (GC) specifically educated bone marrow (BM)-MSCs via secretory exosomes. Exosomal Wnt5a was identified as key protein mediating LNM-GCs education of BM-MSCs, which was verified by analysis of serum exosomes collected from GC patients with LNM.
    [Oncogene]

    Full Article

    Calreticulin as a Special Marker to Distinguish Dental Pulp Stem Cells from Gingival Mesenchymal Stem Cells

    TMT-based quantitative proteomics and two-dimensional gel electrophoresis technology were used in combination to describe the protein profile of dental pulp stem cells and gingival mesenchymal stem cells extracted from the same donor.
    [International Journal of Biological Macromolecules]

    Abstract

    Exosomal hsa_circ_0006859 Is a Potential Biomarker for Postmenopausal Osteoporosis and Enhances Adipogenic versus Osteogenic Differentiation in Human Bone Marrow Mesenchymal Stem Cells by Sponging miR-431-5p

    Hsa_circ_0006859 suppressed osteoblastic differentiation and promoted adipogenic differentiation of hBMSCs.
    [Stem Cell Research & Therapy]

    Full Article

    BMSC-Derived Exosomes Ameliorate Sulfur Mustard-Induced Acute Lung Injury by Regulating the GPRC5A–YAP Axis

    Scientists explored the therapeutic potential of bone marrow-MSC-derived exosomes against acute lung injury and the underlying mechanisms.
    [Acta Pharmacologica Sinica]

    Abstract

    Human BM-MSC Secretome Enhances Human Granulosa Cell Proliferation and Steroidogenesis and Restores Ovarian Function in Primary Ovarian Insufficiency Mouse Model

    The authors report that the human MSC (hMSC) secretome increased the proliferation of human granulosa cells (HGrC1). They showed by FACS analysis that treatment of HGrC1 cells with hMSC-conditioned media stimulated cellular proliferation.
    [Scientific Reports]

    Full Article

    Apigenin Promotes Osteogenic Differentiation of Mesenchymal Stem Cells and Accelerates Bone Fracture Healing via Activating Wnt/β-Catenin Signaling

    Apigenin (API) was found to promote osteogenic differentiation of MSCs. Further investigation showed that API could enhance the expression of the critical transcription factor β-catenin and several downstream target genes of Wnt signaling, thus activated Wnt/β-catenin signaling.
    [American Journal of Physiology-Endocrinology and Metabolism]

    Abstract

    Macrophage Migration Inhibitory Factor Facilitates the Therapeutic Efficacy of Mesenchymal Stem Cells Derived Exosomes in Acute Myocardial Infarction through Upregulating miR-133a-3p

    Exosomes isolated from umbilical cord MSCs (ucMSCs), migration inhibitory factor (MIF) engineered ucMSCs and MIF downregulated ucMSCs were used to investigate cellular protective function in human umbilical vein endothelial cells and H9C2 cardiomyocytes under hypoxia and serum deprivation and infarcted hearts in rats.
    [Journal of Nanobiotechnology]

    Full Article

    Mesenchymal Stem Cell Exosome-Derived miR-223 Alleviates Acute Graft-versus-Host Disease via Reducing the Migration of Donor T Cells

    Investigators performed expression profiling of exosome-miRNAs from human umbilical cord MSCs and murine compact bone MSCs to investigate their immunoregulation effects in acute graft-versus-host disease.
    [Stem Cell Research & Therapy]

    Full Article

    Repair of Segmental Bone Defect Using Tissue Engineered Heterogeneous Deproteinized Bone Doped with Lithium

    Researchers demonstrated that lithium can induce the osteogenic differentiation and inhibit the adipogenic differentiation of BMSCs by regulating the Wnt signaling pathway.
    [Scientific Reports]

    Full Article

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    REVIEWS

    Age-Related Changes in the Inflammatory Status of Human Mesenchymal Stem Cells: Implications for Cell Therapy

    The authors explore the intimate relationship between the inflammatory status of human MSCs (hMSCs) and their in vitro aging process. They posit that a shift from an anti-inflammatory to a pro-inflammatory phenotype of culture-expanded hMSCs contributes to a deterioration in their therapeutic efficacy.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    New Preclinical Study to Investigate the High Potency of Cymerus™ MSCs

    Cynata Therapeutics Limited announced the initiation of a new study to investigate in a pre-clinical model of lung disease the potential molecular mechanisms involved in the observed high potency of Cynata’s proprietary Cymerus™ MSCs.
    [Cynata Therapeutics Limited (GlobeNewswire, Inc.)]

    Press Release

    IMAC Holdings, Inc. Announces Completion of First Cohort of its Phase I Clinical Study of Umbilical Cord-Derived Mesenchymal Stem Cells for the Treatment of Bradykinesia Due to Parkinson’s Disease

    IMAC Holdings, Inc. announced it has completed the first cohort of its Phase I clinical trial for its investigational compound utilizing umbilical cord-derived allogenic MSCs for the treatment of bradykinesia due to Parkinson’s disease.
    [IMAC Holdings, Inc.]

    Press Release

    FEATURED EVENT

    Vesicle Trafficking & Pathways to Neurodegeneration

    May 17 – 19, 2021
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Researcher – Gene-Modified Stem Cells

    National University of Ireland Galway – Galway, Ireland

    Research Assistant – Melanoma Research

    Portland VA Research Foundation – Portland, Oregon, United States

    Postdoctoral Position – Osteoporosis

    University of Southern Denmark – Odense M, Denmark

    Postdoctoral Researcher – Mesenchymal Niche in Leukemia

    Karolinska Institutet – Flemingsberg, Sweden

    Postdoctoral Fellow – Osteoarthritis

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    > See All Jobs

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