 | | Vol. 13.10 – 16 March, 2021 |
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| Alveolar bone monocytes/macrophages expressed a higher level of oncostatin M compared to long bone, which promoted osteogenic differentiation and inhibited adipogenic differentiation of MSCs.
[Bone Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors describe a cellular contractile mechanism employed by fibroblasts and mesenchymal cancer cells to migrate in 3D collagen gels.
[Developmental Cell] |
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| Scientists investigated cell‐cell interaction between MSCs and cerebral endothelial cells. In contrast to bone marrow mononuclear cells, for MSCs they observed suppression of vascular endothelial growth factor uptake into endothelial cells and transfer of glucose from endothelial cells to MSC in vitro.
[Stem Cells] |
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| The effects of mesenchymal stromal cell-like cells on the in vitro differentiation of human monocytes into dendritic cells were investigated.
[iScience] |
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| The importance of MSC miRNAs in modulation of osteoblastic differentiation was examined by global reduction of miRNA biosynthesis in Dicer knock down hMSCs.
[Scientific Reports] |
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| Through a siRNA-based high throughput screen that identified adipogenic regulators whose expression knockdown led to enhanced adipogenic differentiation of human MSCs, two new regulators, SUV39H1, a histone methyltransferase that catalyzes H3K9Me3, and CITED2, a CBP/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 were uncovered.
[Stem Cells and Development] |
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| Researchers identified the aberrant PLK4 upregulation in osteoporosis and downregulation in BMSCs during osteogenic differentiation. In isolated human BMSCs (hBMSCs), PLK4 overexpression significantly inhibited, whereas PLK4 knockdown promoted cell viability and hBMSC osteogenic differentiation.
[Biochemical and Biophysical Research Communications] |
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| Elastin/polycaprolactone/nHA nanofibrous scaffold in combination with mesenchymal stem cells were used to regenerate bone defects. Cytotoxicity, cytocompatibility and cellular morphology were evaluated in vitro and observations revealed that an appropriate environment for cellular attachment, growth, migration, and proliferation is provided by this scaffold.
[Journal of Materials Science-Materials in Medicine] |
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| Researchers revealed that periarteriolar bone marrow-resident NG2+/Nestin+ MSCs could instruct breast cancer disseminated tumor cells to enter dormancy.
[Nature Cancer] |
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| | Investigators developed a bioprinting strategy to engineer prevascularized tissues in vitro and to investigate the capacity of such constructs to enhance the vascularization and regeneration of large bone defects in vivo.
[Acta Biomaterialia] |
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| Researchers established a stringent flow cytometric protocol for the prospective isolation of a CD73+ CD105+ CD271+ bone marrow (BM) stromal cell subpopulation from uncultivated cryopreserved BM of myelodysplastic syndrome and acute myeloid leukemia patients as well as age-matched healthy donors.
[Scientific Reports] |
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| MSCs currently constitute the most frequently used cell type in advanced therapies with different purposes, most of which are related with inflammatory processes.
[Frontiers in Cell and Developmental Biology] |
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| Rubius Therapeutics, Inc. announced initial clinical, pharmacodynamic and tumor trafficking data from its ongoing Phase I/II clinical trial of RTX-240 in patients with advanced solid tumors.
[Rubius Therapeutics, Inc.] |
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| June 21 – 26, 2021
Virtual |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | National University of Ireland Galway – Galway, Ireland |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Karolinska Institutet – Flemingsberg, Sweden |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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