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| Using isogenic Ewing cells, researchers showed STAG2 loss of function profoundly changed the transcriptome but it did not significantly impact EWSR1-FLI1, CTCF/cohesin, or acetylated H3K27 DNA binding patterns.
[Cancer Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| By single-cell transcriptional profiling of nonconditioned, matrix-conditioned, and early differentiating cells, scientists identified distinct MSC subpopulations with distinct mechanosensitivities, differentiation capacities, and cell cycling.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators developed an acellular immunomodulatory biomaterial consisting of an electrospun polycaprolactone/silk fibroin composite fibrous scaffold functionalized with MSC-derived extracellular matrix.
[Acta Biomaterialia] |
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| The authors showed YWHAE-NUTM2 complexed with both BRAF/RAF1 and YAP/TAZ in high-grade endometrial stromal sarcoma (HG-ESS). These interactions were functionally relevant because YWHAE-NUTM2 knockdown in HG-ESS and other models inhibited RAF/MEK/MAPK phosphorylation, cyclin D1 expression, and cell proliferation.
[Oncogenesis] |
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| Scientists described self-assembling tetrapeptide scaffolds for the growth and osteogenic differentiation of human MSCs. The rationally designed peptides were synthetic amphiphilic self-assembling peptides composed of four amino acids that were nontoxic.
[Biomacromolecules] |
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| MSCs were extracted from degenerated intervertebral disc nucleus pulposus, and the expression of miR-140-3p/KLF5/N-cadherin/MDM2/Slug was manipulated to explore their effects on cell proliferation, migration, apoptosis, and differentiation.
[RNA Biology] |
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| Investigators demonstrated that chondrogenic progenitor cells carrying a knockout of RAB5C, a protein involved in endosomal trafficking, exhibited elevated expression of multiple chondrogenic markers, including the SOX trio, and increased COL2 deposition, whereas no changes in COL1 deposition were observed.
[iScience] |
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| To evaluate treated Beta-tricalcium phosphate biocompatibility and osteoblastic differentiation, water-soluble tetrazolium salts-1, immunofluorescence, alkaline phosphatase assay, and quantitative real-time polymerase chain reaction were done using human MSCs.
[Scientific Reports] |
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| The authors elucidated the significance of glypican-1, a heparan sulfate proteoglycan, in regulating the activation of human bone marrow-derived stromal cells of fibroblast lineage.
[Scientific Reports] |
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| Scientists uncovered a molecular fate switch, involving miR-206 and the transcription factor Runx1, that controls fibroadipogenic progenitor differentiation to adipocytes.
[Cell Stem Cell] |
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| Investigators assessed the safety/efficacy of a tissue–engineered biocomplex in periodontal reconstruction.
[Journal of Periodontology] |
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| The authors discuss the normal processes of bone and tooth development, followed by disorders that have effects on both bone and teeth, versus disorders that have effects in one without affecting the other.
[Nature Reviews Endocrinology] |
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| Investigators highlight the therapeutics effects of adipose tissue mesenchymal cell–derived extracellular vesicles related to their participation in relevant biological processes including inflammation, angiogenesis, cell proliferation, apoptosis, and migration, among others.
[Stem Cell Reviews and Reports] |
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| Researchers explore the several mechanisms through which MSCs impact the supportive activity of the bone marrow niche and regulate hematopoietic stem and progenitor cell homeostasis.
[Frontiers in Cell and Developmental Biology] |
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| Hope Biosciences Stem Cell Research Foundation received FDA authorization for a Phase II clinical trial to assess the efficacy and safety of multiple intravenous infusions of autologous adipose-derived MSCs in improving activities of daily living and quality of life in subjects with Parkinson’s Disease.
[Hope Biosciences Stem Cell Research Foundation] |
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| January 12 – 14, 2022
Shanghai, China |
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| | Washington University in St. Louis – Saint Louis, Missouri, United States |
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| | Columbia University Medical Center – New York City, New York, United States |
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| | Zhejiang University – Zhejiang, China |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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