 | | Vol. 13.24 – 22 June, 2021 |
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| Researchers explored fibroblast heterogeneity in keloid, a paradigm of fibrotic skin diseases, by using single-cell RNA-seq.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists investigated the benefit of a combined-tissue engineering strategy by loading homologous bone MSCs and Schwann cells in 3D scaffolds.
[Biofabrication] |
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| Investigators sought to define the specific contributions of each FLI domain to EWS/FLI activity in a well-validated Ewing sarcoma model and, in doing so, to better understand Ewing sarcoma development mediated by the fusion protein.
[Oncogene] |
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| The authors investigated molecular mechanisms underlying circular RNA AFF4-regulated bone marrow-derived-MSCs osteogenesis.
[Cell Death & Disease] |
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| Using glioblastoma patient-derived stem cells, researchers identified and characterized a subset of Gal-3high glioblastoma tumors mainly within the mesenchymal subtype that was addicted to Gal-3-mediated macropinocytosis.
[Communications Biology] |
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| The authors investigated insulin-producing cell generation from two practical canine MSCs, canine bone marrow-derived MSC, and canine adipose-derived MSCs.
[Scientific Reports] |
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| Parathyroid hormone (PTH) and sclerostin inhibitor (SOSTi) are bone anabolic agents that are administered to patients with osteoporosis. Scientists tested whether osteolectin mediated the effects of PTH or SOSTi on bone formation.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The pathogenic mechanisms underlying joint dysfunction in osteogenesis imperfecta are poorly understood. Researchers generated a mouse model in which Fkbp10 was conditionally deleted in tendons and ligaments.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists showed that exosomes containing circ_0008542 from MC3T3-E1 cells with prolonged tensile stimulation promoted osteoclast differentiation and bone resorption.
[Cell Death & Disease] |
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| Researchers presented an effective strategy to reverse the aging of mouse bone marrow MSCs by restoring their mitochondrial functionality using photobiomodulation therapy.
[Scientific Reports] |
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| Investigators elaborate on all mentioned contradictory data and provides a realistic, current clinical perspective on MSCs’ potential in glioblastoma treatment.
[Biochimica Et Biophysica Acta-Reviews On Cancer] |
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| The authors cover the existing applications in various aspects of MSC behavior, followed by pluripotent and neural stem cells (SCs), with a few reports addressing other SC types.
[Stem Cell Reviews and Reports] |
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| Moleculin Biotech, Inc. announced it has commenced enrollment and dosed the first subject in its US Phase Ib/II clinical trial evaluating Annamycin for the treatment of soft tissue sarcoma lung metastases.
[Moleculin Biotech, Inc.] |
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| Hope Biosciences Stem Cell Research Foundation has received FDA authorization for a Phase II clinical trial to assess the efficacy and safety of multiple intravenous infusions of allogeneic adipose-derived MSCs in improving activities of daily living and quality of life in subjects with Parkinson’s Disease.
[Hope Biosciences] |
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| July 22 – 23, 2021
Virtual |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | University of Southern California – Los Angeles, California, United States |
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| | Hannover Medical School – Hannover, Germany |
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| | Sana Biotechnology – Multiple Locations, United States |
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| | H. Lee Moffitt Cancer Center – Tampa, Florida, United States |
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