 | | Vol. 13.29 – 27 July, 2021 |
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| Using the sea urchin larva, the authors examined the otopetrin ortholog otop2l, which was exclusively expressed in the calcifying primary mesenchymal cells that generated calcitic larval skeleton.
[Proceedings of the National Academy of Sciences of the United States of America] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators identified that osteosarcoma cells commonly exhibited high platelet activation-inducing characteristics, and molecules released from activated platelets promoted the invasiveness of osteosarcoma cells.
[Oncogene] |
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| A new strategy to modify MSCs to express specific chemokine receptors using mRNA engineering was developed to evaluate the homing ability of MSCs and their therapeutic effects for inflammatory bowel disease.
[Molecular Therapy-Nucleic Acids] |
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| Investigators reported a series of 35 cases comprising 25 intimal sarcomas (ISA) of the pulmonary artery, one ISA of the renal artery, and nine undifferentiated pleomorphic sarcomas of the left atrium.
[Modern Pathology] |
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| Researchers investigated the role of the GITR-GITRL pathway in mediating the resistance to therapy. They found that GITR and GITRL expressions were higher in the sarcomatoid cell line than in non-sarcomatoid cell lines.
[Communications Biology] |
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| The authors investigated the beneficial effects of exosomes derived from bone marrow MSCs on trabecular meshwork cells under oxidative stress and predicted candidate genes associated with this process.
[Scientific Reports] |
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| Scientists presented an integrative analysis of clinical data, cytokines, serum metabolomics in rheumatoid arthritis patients, and mechanistic studies on adenosine deaminase-mediated effects on in vitro cell culture models.
[Scientific Reports] |
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| Researchers described 12 BCORL1-altered uterine sarcomas with a striking resemblance to BCOR-altered endometrial stromal sarcoma.
[Modern Pathology] |
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| Scientists studied the effect of adipose-derived MSCs on obesity-induced multi-organ injuries in a diet-induced obese mouse model.
[Tissue Barriers] |
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| Investigators evaluated the effects of MSC-extracellular vesicles on chondrocyte proliferation in vitro and on cartilage repair in vivo following bone marrow stimulation of focal chondral defects of the knee.
[Cartilage] |
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| Researchers revealed the function of bone marrow MSC-derived exosomes in sepsis-induced myocardial injury and the molecular mechanism.
[Immunopharmacology and Immunotoxicology] |
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| The authors summarize fibroblast development, lineages, functions, and contributions to fibrosis in four fibroblast-rich organs: skin, lung, skeletal muscle, and heart.
[Cell] |
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| EV Biologics Corp. announced that it has signed a Letter of Intent (LOI) with Lonza Cell & Gene Therapy for Process Development and Gap Analysis for biomanufacturing of a novel therapeutic composition, comprising extracellular vesicles and particles, as well as other secreted factors derived from selected stem/progenitor cells, such as MSCs.
[EV Biologics Corp. (BioSpace)] |
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| The California stem cell agency awarded $51 million to help train students in the art of research at the Golden State’s community colleges and universities.
[Capitol Weekly] |
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| February 14 – 17, 2022
Puerto Vallarta, Mexico |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | The Children’s Hospital of Philadelphia – Philadelphia, Pennsylvania, United States |
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| | Marion duPont Scott Equine Medical Center – Washington, DC, United States |
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| | Mercer University – Savannah, Georgia, United States |
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| | Florida State University – Tallahassee, Florida, United States |
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