 | | Vol. 13.33 – 24 August, 2021 |
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| The change of morphology, immunophenotype and capacity of proliferation, differentiation and immunoregulation of MSCs at passage (P) 4, P6, P8, P10 and P12 was investigated.
[Molecular Therapy-Nucleic Acids] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Designed 3D-PLA/Gel/Mg-nHAp scaffolds were attributed to various characterizations for the examination of their physicochemical, mechanical properties, cyto-compatibility, and biodegradability as well as their ability to promote osteogenesis in vitro.
[Biotechnology Journal] |
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| The protein levels of osteogenesis-related genes, let-7i-5p, frizzled class receptor 4, Ki67, Wnt6 and β-catenin were measured by western blot assay. The levels of circ_FBLN1, FBLN1 mRNA and FZD4 mRNA were determined by quantitative real-time PCR assay.
[Journal of Bioenergetics and Biomembranes] |
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| Aiming for safety and reproducibility of cell therapy in clinical practice by using sources easily obtained that are usually discarded, researchers isolated, characterized, and evaluated the proliferation and colony formation potential of canine dental pulp-derived MSCs and canine umbilical cord tissue.
[Research in Veterinary Science] |
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| Allogeneic, bone marrow-derived MSCs were systemically administered into patients with stable chronic obstructive pulmonary disease. Gene expression profiles from peripheral blood mononuclear cells were analyzed across the first week after infusion.
[Stem Cells Translational Medicine] |
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| A rabbit alveolar process cleft model was established by removing the bone tissue from the left maxillary bone. 48 young Japanese white rabbits were divided into normal, control, material and mesenchymal stem cell groups.
[Stem Cell Reviews and Reports] |
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| Human monocytes were educated by exosomes from lipopolysaccharide-primed MSCs and compared to monocytes educated by unprimed MSCs and uneducated monocytes to assess survival and clinical improvement in a xenogeneic mouse model of acute radiation syndrome.
[Stem Cell Research & Therapy] |
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| Researchers examined whether serum-free medium and hypoxic preconditioning synergistically enhance the therapeutic effects of MSCs on renal fibrosis in rats with ischemia-reperfusion injury.
[Stem Cell Research & Therapy] |
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| Investigators showed that intramuscular injection of placental (P)-MSCs homed more towards the visceral site, restored HOMA-IR and glucose homeostasis in the WNIN/GR-Ob rats. P-MSC therapy was effective in re-establishing the dysregulated cytokines.
[Scientific Reports] |
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| After warm acupuncture combined with bone-marrow MSCs, the Modified Lequesne MG knee joint assessment scale was used to evaluate the degree of knee joint behavior, the Taiping Peng method generally observed the histomorphology changes of knee osteoarthritis rabbit cartilage, and hematoxylin-eosin staining, safranin O green staining, and toluidine blue staining were conducted to evaluate the extent of cartilage tissue pathology.
[Evidence-Based Complementary and Alternative Medicine] |
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| Scientists systematically review preclinical studies, explored the effectiveness of MSCs in the treatment of bleomycin-induced pulmonary fibrosis and analyze the potential mechanism, combined with clinical trials of current MSCs for idiopathic pulmonary fibrosis and COVID-19, so as to provide support for clinical research and transformation of MSCs.
[Stem Cell Research & Therapy] |
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| The authors highlight the interactions between MSCs and different immune cells to mediate immunomodulatory functions along with the importance of MSCs therapy for the successful islet transplantation.
[Biomedicine & Pharmacotherapy] |
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| Bonus BioGroup LTD, has received official approval from the Israeli Ministry of Health to expand its phase II clinical trials for its MesenCure treatment to health centers and hospitals nationwide. MesenCure leverages advances in cell therapy to treat COVID-19 patients suffering from life-threatening pneumonia, acute respiratory distress, and associated complications caused by the immune system’s hyper-inflammatory response to the virus.
[Bonus BioGroup LTD (GlobeNewswire, Inc.)] |
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| June 5 – 10, 2022
Ventura, California, United States |
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| | Duke University – Durham, North Carolina, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Michigan State University – East Lansing, Michigan, United States |
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| | Danaher – Toronto, Ontario, Canada |
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| | Michigan State University – East Lansing, Michigan, United States |
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