Mesenchymal Cell News Volume 13.36 | Sep 14 2021

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    2021-09-14 | MESCN 13.36


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 13.36 – 14 September, 2021
    TOP STORY

    Mithramycin Delivery Systems to Develop Effective Therapies in Sarcomas

    Polylactide polymeric nanoparticles were generated by nanoprecipitation. Liposomes were prepared by ethanol injection and evaporation solvent method.
    [Journal of Nanobiotechnology]

    Full Article
    Resources for Your T Cell Therapy Research
    PUBLICATIONSRanked by the impact factor of the journal

    Human Adipose-Derived Mesenchymal Stromal Cells Exhibit High HLA-DR Levels and Altered Cellular Characteristics under a Xeno-Free and Serum-Free Condition

    Scientists cultured adipose-derived MSCs from seven donors in PowerStem MSC1 media and StemMACS MSC Expansion Media and examined their growth and colony-forming ability, surface marker expression, differentiation, cell cycle and senescence, as well as genetic stability of two passages representing an early and late passage for therapeutic MSCs.
    [Stem Cell Reviews and Reports]

    Full ArticleGraphical Abstract

    Human Amniotic Stem Cells-Derived Exosmal miR-181a-5p and miR-199a Inhibit Melanogenesis and Promote Melanosome Degradation in Skin Hyperpigmentation, Respectively

    The authors reported that both human amniotic stem cells and their conditional medium had a potent anti-hyperpigmentation in skin in vivo and in vitro.
    [Stem Cell Research & Therapy]

    Abstract

    Analysis of the Signal Cross Talk via CCL26 in the Tumor Microenvironment in Osteosarcoma

    Investigators identified the humoral factor involved in the association between tumor cells and surrounding normal cells using a co-culture model and investigated the significance of their findings.
    [Scientific Reports]

    Full Article

    Long-Term Stability, High Strength, and 3D Printable Alginate Hydrogel for Cartilage Tissue Engineering Application

    Researchers developed a double crosslinked alginate hydrogel for 3D bioprinting, and human umbilical cord MSCs could differentiate into chondrocytes on its printed 3D scaffold after four weeks’ culture.
    [Biomedical Materials]

    Abstract

    Construction of Transplantable Artificial Vascular Tissue Based on Adipose Tissue-Derived Mesenchymal Stromal Cells by a Cell Coating and Cryopreservation Technique

    The authors constructed an artificial vascular tissue constructed by human adipose tissue-derived stromal cells and umbilical vein-derived endothelial cells by a modified technique with cryopreservation.
    [Scientific Reports]

    Full Article

    Extracellular Vesicles Derived from CD73 Modified Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Inflammation after Spinal Cord Injury

    Effects of CD73+ human umbilical cord MSC-EVs on hydrolyzing ATP into adenosine were detected. The polarization of M2/M1 was verified by immunofluorescence.
    [Journal of Nanobiotechnology]

    Full Article

    Human Wharton’s Jelly-Derived Mesenchymal Stem Cells Alleviate Concanavalin A-Induced Fulminant Hepatitis by Repressing NF-κB Signaling and Glycolysis

    A well-established concanavalin A-induced fulminant hepatitis mouse model was used to investigate the effects of transplanting human umbilical cord Wharton’s jelly-derived MSCs on fulminant hepatitis.
    [Stem Cell Research & Therapy]

    Full Article

    Mesenchymal Stem Cells Attenuate Liver Fibrosis by Targeting Ly6Chi/Lo Macrophages through Activating the Cytokine-Paracrine and Apoptotic Pathways

    The authors showed dual regulatory functions of bone marrow-derived MSC in attenuating hepatic fibrosis by promoting Ly6Chi/Ly6Clo subset conversion and Ly6Clo macrophage restoration through secreting antifibrogenic-cytokines and activating the apoptotic pathway.
    [Cell Death Discovery]

    Full Article

    Chicken Bone Marrow Mesenchymal Stem Cells Improve Lung and Distal Organ Injury

    Researchers separated chicken bone marrow-derived mesenchymal stem cells (BM-MSCs); investigated whether BM-MSCs could improve lipopolysaccharide-induced lung and distal organ injury; and explored the underlying mechanisms.
    [Scientific Reports]

    Full Article

    Safety and Feasibility of Autologous Olfactory Ensheathing Cell and Bone Marrow Mesenchymal Stem Cell Co-Transplantation in Chronic Human Spinal Cord Injury: A Clinical Trial

    Three individuals with the traumatic spinal cord injury of the thoracic level were enrolled. They received the autologous olfactory ensheathing cell and MSC combination through the lumbar puncture.
    [Spinal Cord]

    Abstract
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    REVIEWS

    Mesenchymal Stem Cell Therapy for Severe COVID-19

    Investigators summarize the recent progress in MSC therapy for COVID-19 and highlight the challenges in the field.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Mesenchymal Stem Cell Therapy for Alzheimer’s Disease

    The authors compile pertinent preclinical Alzheimer’s disease research on transgenic mice as well as clinical trials on MSC-based therapy from diverse sources.
    [Stem Cells International]

    Full Article
    INDUSTRY AND POLICY NEWS

    Research on Preterm Brain Injury Treatment Recognised

    Dr. Lindsay Zhou recieved the 2021 European Society for Pediatric Research Young Investigator Start Up Grant of 10,000 Euros for research on treatment for preterm brain injury. The project is investigating the use of umbilical cord blood-derived stem cells as a treatment for preterm brain injury.
    [Monash University]

    Press Release

    Researchers Awarded $31 Million for Clinical Trials to Treat Stroke, Heart Failure, Brain Cancer

    The California Institute for Regenerative Medicine has awarded $31 million to three Stanford researchers to launch trials of treatments for common diseases. Four other Stanford researchers also received a total of $4.55 million.
    [Stanford Medicine]

    Press Release
    FEATURED EVENT

    Cell & Gene Meeting on the Mesa

    October 12 – 14, 2021
    Carlsbad, California, United States and Virtual

    > See All Events

    JOB OPPORTUNITIES

    Scientist – Mesenchymal Stem Cell Lineages

    Broad Institute – Cambridge, Massachusetts, United States

    Research Associate – Organogenesis, Stem Cell, snad Regenerative Medicine

    University of Southern California – Los Angeles, California, United States

    Postdoctoral Fellow – Hematopoietic and Mesenchymal Cells

    Lund University – Lund, Sweden

    Advanced Practice Provider – Stem Cell Transplantation

    Banner MD Anderson Cancer Center – Gilbert, Arizona, United States

    Postdoctoral Associate – Tumor Microenvironment

    Duke University – Durham, North Carolina, United States

    > See All Jobs

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