 | | Vol. 13.44 – 9 November, 2021 |
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| Among various cell sources, FGL1/PD-L1 small extracellular vesicles (sEVs) derived from MSCs not only enriched FGL1/PD-L1 expression but also maintained the immunomodulatory properties of unmodified MSC sEVs.
[Advanced Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that Lyve-1+ tumor-associated macrophages supported tumor growth and identified a pivotal role for these cells in maintaining a population of perivascular mesenchymal cells that expressed α-smooth muscle actin and phenotypically resembled pericytes.
[Science Advances] |
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| Researchers established an alginate hydrogel system with constant stiffness and tunable stress relaxation rate, which was a key parameter for the viscoelastic property of the material.
[Biomaterials] |
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| Investigators presented a high-throughput, scalable, low-cost, on-chip microfluidic potency assay with improved functional predictive power and recapitulation of in vivo secretory responses compared to traditional approaches.
[Advanced Healthcare Materials] |
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| The authors showed that donor differences in human MSC (hMSC) transcriptome were minor relative to the intrinsic differences in tissue-of-origin. hMSCs with different transcriptomic profiles showed potential differences in functional characteristics.
[Stem Cell Research & Therapy] |
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| Scientists prepared a functional cell derived extracellular matrix biomaterial enriched with VEGFA and bFGF, which induced endothelial differentiation of human umbilical cord MSCs and promoted angiogenesis, which may improve the healing effect of skin injury.
[Biomedical Materials] |
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| Researchers investigated the expression of N-Cadherin, a trans-membrane protein that enhanced the cell adhesion and recently gained attention for differentiation and augmentation of stem cell function, in mouse cardiac MSCs.
[Cell Biology International] |
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| Investigators explored the effects of PPARβ/δ agonist on the regeneration of diabetic bone defects and the osteogenic differentiation of rat bone marrow MSCs under a pathological high-glucose condition.
[Stem Cell Research & Therapy] |
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| The authors demonstrated the major role of PPP1R15A in the regulation of lung mesenchymal cells, and regulation of PPP1R15A may represent a novel therapeutic strategy in idiopathic pulmonary fibrosis.
[Scientific Reports] |
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| Researchers demonstrated the protective effects of low-molecular-weight adipose-derived stem cell-conditioned medium in a mouse model of dry eye syndrome.
[Scientific Reports] |
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| Brain-derived neurotrophic factor promoted hematopoietic regeneration via activation of PDGFRα+ bone marrow MSCs which increased secretion of hematopoietic cytokines interleukin 6 and leukemia inhibitory factor in response to TrkB activation.
[PLoS One] |
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| Scientists investigated the effect of insulin-producing cells derived from adipose tissue MSCs on diabetic-induced impairments as the abnormalities of testicular tissues, oxidative stress of testes, and defects of spermatogenesis.
[Heliyon] |
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| The authors analyze the existing researches and elaborate on the functions of MSCs in cancer progression and anticancer therapeutic resistance, demonstrating that MSCs may be a viable cancer therapeutic target.
[Cancer Cell International] |
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| Investigators discuss the accumulating evidence indicating the therapeutic potential of the MSC-conditioned medium in periodontal regeneration-related pre-clinical and clinical studies.
[Journal of Translational Medicine] |
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| Sumitomo Dainippon Pharma Oncology, Inc. announced that the first patient has been dosed in the Phase I dose expansion portion of the study evaluating the investigational agent TP-1287, an oral cyclin-dependent kinase 9 inhibitor, in patients with sarcoma.
[Sumitomo Dainippon Pharma Oncology, Inc.] |
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| December 1 – 10, 2021
Virtual |
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| | The University of Sheffield – Sheffield, England, United Kingdom |
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| | University of Southern California School of Dentistry – Los Angeles, California, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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