 | | Vol. 14.10 – 15 March, 2022 |
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| Researchers investigated whether a multifactorial neonatal mouse model of lung injury perturbed neural progenitor cell function and assessed the ability of human umbilical cord-derived MSC extracellular vesicles to mitigate pulmonary and neurologic injury.
[American Journal of Respiratory and Critical Care Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors reported a non-invasive all-optical strategy to induce stem cell differentiation in vitro and in vivo that activated individual target stem cells in situ by delivering a transient 100-ms irradiation of a tightly focused femtosecond laser to a submicron cytoplasmic region of primary adipose-derived stem cells.
[Cell Reports] |
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| Investigators used in vitro and in vivo assays to demonstrate that articular cartilage and bone ECM derived scaffolds could preferentially direct the differentiation of mesenchymal stromal cells (MSCs) towards either a chondrogenic or osteogenic lineage, respectively.
[Acta Biomaterialia] |
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| Scientists showed that bone marrow-derived MSCs contributed to fibrosis in myeloproliferative neoplasms by differentiating into αSMA-positive myofibroblasts.
[Experimental & Molecular Medicine] |
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| Researchers tested the hypothesis that introducing positively charged amino acids into Hexon might have enhanced the transduction of human MSCs, enabling efficient expression of selected transgenes.
[Molecular Therapy-Methods & Clinical Development] |
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| Engineered 3D tuneable biomimetic scaffolds were used to control the cell microenvironment of adipose-derived MSCs, which exhibited a collagen density-specific profile for early and late stage bone cell lineage status.
[iScience] |
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| Investigators explored the effect of small extracellular vesicles from induced pluripotent stem cell-derived MSCs on acute pain and investigated the underlying mechanisms.
[Nanomedicine] |
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| The authors extracted and identified primary MSCs and verified the promoting effects of tumor-associated MSCs on colorectal cancer proliferation and metastasis in vivo and in vitro.
[Molecular Therapy] |
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| Scientists found that curcumin primed adipose tissue-derived MSCs-derived small extracellular vesicles (ADMSCs-sEVs) exhibited an enhanced protective effect compared with free curcumin and ADMSCs-sEV in TBHP-induced chondrocytes.
[Journal of Nanobiotechnology] |
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| The authors indicated that administration of morpholino with or without chemotherapeutics could substantially improve osteosarcoma (OS) outcomes with respect to tumor expansion and osteolytic corruption of bone in an experimental OS model.
[British Journal of Cancer] |
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| Since MSCs have been shown to have low immunogenicity and often survive in allogeneic recipients, researchers attempted to use these cells for induction of transplantation tolerance.
[Stem Cell Reviews and Reports] |
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| MSCs were comparable to N-acetylcysteine against acetaminophen (APAP)-induced liver failure by secreting hepatocyte growth factor with less regenerative retardation concerns, thus facilitating the application of MSCs in clinical therapy for APAP liver failure.
[Stem Cell Research & Therapy] |
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| Compared to using MSCs or rh-ACE2 alone, the administration of ACE2-MSCs much more significantly reduced inflammatory factors and pyroptosis factors and alleviated lung injury in vivo and in vitro, which may have been due to the increased activities of secretory ACE2.
[iScience] |
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| The authors focus on the role of leucine-rich repeat-containing protein (LRRC15) in cancer, including clinical trials involving LRRC15-targeted therapies, such as the ABBV-085 ADC for patients with LRRC15-positive tumors.
[Cancer Research] |
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| Scientists summarize the major pathological characteristics of COVID-19 and provide scientific and rational evidence for the safety and possible effectiveness of MSCs in COVID-19 treatment.
[Ebiomedicine] |
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| BioRestorative Therapies, Inc., a clinical stage company focused on stem cell-based therapies, announced that it has entered into a research collaboration agreement with Dr. Tore Bengtsson, Professor of the Department of Molecular Biosciences, at the Wenner-Gren Institute, at Stockholm University.
[BioRestorative Therapies, Inc. (Globe Newswire, Inc.)] |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | Johns Hopkins University School of Medicine – Baltimore, Maryland, United States |
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| | Aspect Biosystems – Vancouver, British Columbia, Canada |
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| | University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | Singapore-MIT Alliance for Research and Technology (SMART) Centre – Singapore, Singapore |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
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Intestinal Cell News
Mammary Cell News
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Neural Cell News
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Pancreatic Cell News
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