Mesenchymal Cell News Volume 14.18 | Nov 21 2023

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    2023-11-21 | MESN 15.45


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 14.18 – 21 November, 2023
    TOP STORY

    Immunobiology of Foreign Body Response to Composite PLACL/Gelatin Electrospun Nanofiber Meshes with Mesenchymal Stem/Stromal Cells in a Mouse Model: Implications in Pelvic Floor Tissue Engineering and Regeneration

    Researchers proposed a tissue engineering strategy using uterine endometrium-derived mesenchymal stem/stromal cells delivered with degradable poly L-lactic acid-co-poly ε-caprolactone and evaluated the immunomodulatory mechanism at the material interfaces.
    [Biomaterials Advances]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Lactate: An Alternative Pathway for the Immunosuppressive Properties of Mesenchymal Stem/Stromal Cells

    Scientists evaluated the role of lactate as an alternative mediator of MSC immunosuppressive properties and its contribution to the enhanced immunoregulatory activity of glycolytic MSCs.
    [Stem Cell Research & Therapy]

    Full Article

    Mesenchyme Governs Hair Follicle Induction Icon for the Forest of Biologists

    Investigators performed epithelial-mesenchymal tissue recombination experiments using hair-forming back skin and glabrous plantar skin from mouse embryos to unveil that the back skin mesenchyme was inductive even before dermal condensate formation.
    [Development]

    Abstract

    Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Promote Microcirculation in Aged Diabetic Mice by TGF-β1 Signaling Pathway

    Human MSC-derived exosomes were extracted by hypervelocity centrifugation method, and exosome morphology was observed by transmission electron microscopy, exosome diameter distribution was detected by particle size analysis, and exosome specific proteins were identified by Western blot.
    [Diabetology & Metabolic Syndrome]

    Full Article

    Microfabrication of Gelatin Methacrylate/Hydroxyapatite Composites by Utilizing Alternate Soaking Process

    Hydrogel models of polymerized gelatin methacrylate were fabricated by using stereolithography and modified with hydroxyapatite via an alternate soaking process using a solution of calcium and phosphate ions.
    [ACS Biomaterials Science & Engineering]

    AbstractGraphical Abstract

    Mesenchymal Stem Cell-Derived Exosomes Enriched with miR-218 Reduce the Epithelial–Mesenchymal Transition and Angiogenesis in Triple-Negative Breast Cancer Cells

    Researchers used adipose MSCs-derived exosomes for miR-218 delivery to breast cancer cells and evaluate miR-218 tumor-suppressing properties in vitro.
    [European Journal Of Medical Research]

    Full Article

    BRD4 Facilitates Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells Through WNT4/NF-κB Pathway

    Bromodomain-containing protein 4 (BRD4) promoted human bone marrow MSCs osteogenic differentiation by inhibiting NF-κB pathway via enhancing WNT family members-4 (WNT4) expression.
    [Journal Of Orthopaedic Surgery And Research]

    Full Article

    Pretreatment of UC-MSCs with IFN-α2 Improves Treatment of Liver Fibrosis by Recruiting Neutrophils

    Researchers explored therapeutic umbilical cord (UC)-MSC phenotypes for improving liver fibrosis. RNA-sequencing was used to analyze the response pattern of UC-MSCs after exposure to the serum of cirrhotic patients with HBV.
    [Journal Of Translational Medicine]

    Full Article

    The Influence of Inflammation on the Characteristics of Adipose-Derived Mesenchymal Stem Cells (ADMSCs) and Tissue Repair Capability in a Hepatic Injury Mouse Model

    Scientists analyzed the effects of tissue inflammation on the characteristics of MSCs. Human fat derived from the infrapatellar fat pad of knees with differing degrees of inflammation was extracted from specimens derived from total knee arthroplasties.
    [Stem Cell Research & Therapy]

    Full Article
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    REVIEWS

    Epitranscriptomic Modifications in Mesenchymal Stem Cell Differentiation: Advances, Mechanistic Insights, and Beyond

    The authors highlight current challenges and potential future directions in the study of RNA modifications in MSCs, emphasizing the need for innovative tools to precisely map these modifications and decipher their context-specific effects.
    [Cell Death & Differentiation]

    Abstract
    INDUSTRY AND POLICY NEWS

    SMART Pioneers Microfluidic Method to Optimise Stem Cell Extraction for Advanced Cell Therapies

    Researchers from SMART, MIT’s research enterprise in Singapore have developed a groundbreaking technology capable of extracting MSCs directly from pure bone marrow without dilution.
    [Singapore-MIT Alliance for Research and Technology (SMART)]

    Press Release
    FEATURED EVENT

    Stem Cells and Regeneration

    January 22 – 25, 2024
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    JOB OPPORTUNITIES

    Assistant Project Scientist – Mesenchymal Progenitor Cells and Perivascular Stem Cells

    University of California, Los Angeles – Los Angeles, California, United States

    Research Associate – Cell Biology R&D

    Applied Stem Cell – Milpitas, California, United States

    Research Positions – Cancer Research Center

    German Cancer Research Center in the Helmholtz Association – Heideland, Germany

    Assistant Project Scientist – Mesenchymal Progenitor Cells and Perivascular Stem Cells

    University of California, Los Angeles – Los Angeles, California, United States

    Scientist Positions – Pharmaceutical Sciences

    China Pharmaceutical University – Nanjing, Jiangsu, China

    > See All Jobs

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