Mesenchymal Cell News Volume 14.37 | Sep 20 2022

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    2022-09-20 | MESCN 14.37


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 14.37 – 20 September, 2022
    TOP STORY

    Human Mesenchymal Stem Cells and Derived Extracellular Vesicles Reduce Sensory Neuron Hyperexcitability and Pain Behaviors in Murine Osteoarthritis

    Investigators determined whether MSCs and/or derived extracellular vesicles reduced knee osteoarthritis (OA) pain through influencing sensory neuron excitability in OA joints.
    [Arthritis & Rheumatology]

    Abstract

    Dr. Fabio Rossi discusses the role of mesenchymal stem cells in tissue repair and development.
    PUBLICATIONSRanked by the impact factor of the journal

    Induction of Functional Xeno-Free MSCs from Human iPSCs via a Neural Crest Cell Lineage

    Scientists transplanted the xeno-free-induced MSCs into mouse models for bone and skeletal muscle regeneration and confirmed their regenerative potency.
    [NPJ Regenerative Medicine]

    Full Article

    Non-Myogenic Mesenchymal Cells Contribute to Muscle Degeneration in Facioscapulohumeral Muscular Dystrophy Patients

    By characterizing non-myogenic MSC population in facioscapulohumeral muscular dystrophy patients’ muscles, researchers were able to identify signs of disease activity by muscle magnetic resonance imaging.
    [Cell Death & Disease]

    Full Article

    Conglomeration of T and B Cell Matrix Responses Determines the Potency of Human Bone Marrow Mesenchymal Stromal Cells

    Scientists investigated the effect of MSCs on B cell matrix responses to be incorporated into the assay matrix potency analytical system.
    [Stem Cells]

    AbstractGraphical Abstract

    Mesenchymal Stromal Cells Induced Regulatory B Cells Are Enriched in Extracellular Matrix Genes and IL-10 Independent Modulators

    Investigators characterized MSC induced Regulatory B cells (iBreg) and identified specific Breg biomarkers by RNAseq.
    [Frontiers in Immunology]

    Full Article

    Environmental Oxygen Affects Ex Vivo Growth and Proliferation of Mesenchymal Progenitors by Modulating Mitogen-Activated Protein Kinase and Mammalian Target of Rapamycin Signaling

    The authors compared MSC cultures simultaneously grown under a conventional 19.95% O2 atmosphere or at 5% O2.
    [Cytotherapy]

    Abstract

    The Potential Role of Integrin Alpha 6 in Human Mesenchymal Stem Cells

    Researchers determined that the expression of integrin alpha 6 (ITGA6) and ITGA6 antisense RNA correlated with the proliferation, cell size, and differentiation potential.
    [Frontiers in Genetics]

    Full Article

    Alpinetin Alleviates Osteoporosis by Promoting Osteogenic Differentiation in BMSCs by Triggering Autophagy via PKA/mTOR/ULK1 Signaling

    Scientists found that alpinetin treatment was able to enhance osteogenic differentiation levels of human bone marrow MSCs in vitro and mouse ones in vivo as revealed by multiple osteogenic markers.
    [Phytotherapy Research]

    Full Article

    Integration of Transcriptomics and Metabolomics Reveals Pathways Involved in MDSC Supernatant Attenuation of TGF-β1-Induced Myofibroblastic Differentiation of Mesenchymal Stem Cells

    Bone marrow MSCs were collected 24 h following TGF-β1 and myeloid-derived suppressor cell (MDSC) supernatant treatment for RNA sequencing and untargeted metabolomic analysis.
    [Cell and Tissue Research]

    Abstract
    How to prioritize and manage your research projects
    REVIEWS

    Mesenchymal Stem Cell-Derived Exosomes in Cancer Therapy Resistance: Recent Advances and Therapeutic Potential

    Scientists systematically summarize the emerging roles and detailed molecular mechanisms of MSC-derived exosomes in mediating cancer therapy resistance.
    [Molecular Cancer]

    Full Article

    The Characteristics and Survival Potential under Sub-Lethal Stress of Mesenchymal Stromal/Stem Cells Isolated from the Human Vascular Wall

    Investigators review the main findings regarding the MSCs isolated from the human vascular wall.
    [Stem Cells]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    TRACON Pharmaceuticals Announces Fast Track Designation by the FDA for Envafolimab for the Treatment of the Soft Tissue Sarcoma Subtypes of UPS and MFS

    TRACON Pharmaceuticals, Inc. announced that the US FDA has granted fast-track designation for the development of envafolimab for patients with locally advanced, unresectable undifferentiated pleomorphic sarcoma (UPS) and myxofibrosarcoma (MFS).
    [TRACON Pharmaceuticals, Inc.]

    Press Release
    FEATURED EVENT

    Cell Symposia: Multifaceted Mitochondria

    November 6 – 8, 2022
    Seville, Spain

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Mammalian Morphogenesis

    UC San Francisco – San Francisco, California, United States

    Research Specialist – Stem Cell Biology

    Karolinska Institutet – Flemingsberg, Sweden

    Assistant Professor – Stem Cell Biology

    University of California Santa Cruz – Santa Cruz, California, United States

    Research Technologist – Tissue and Cell Biology

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Associate Researcher – Translational Cancer Research

    Icahn School of Medicine at Mount Sinai – New York City, New York, United States

    > See All Jobs

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