Mesenchymal Cell News Volume 14.40 | Oct 11 2022

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    2022-10-11 | MESCN 14.40


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 14.40 – 11 October, 2022
    TOP STORY

    Fast Stress Relaxing Gellan Gum That Enhances the Microenvironment and Secreting Function of Bone Mesenchymal Stem Cells

    Human-derived bone marrow stem cells showed an enhanced release profile of growth factors and exosomes in a fast stress-relaxing gellan gum hydrogel.
    [International Journal of Biological Macromolecules]

    Abstract
    Five tips for returning to the lab after time off
    PUBLICATIONSRanked by the impact factor of the journal
    IN VITRO

    ETV2 Promotes Osteogenic Differentiation of Human Dental Pulp Stem Cells through the ERK/MAPK and PI3K-Akt Signaling Pathways

    Researchers evaluated the effects of Dox-induced overexpression of Ets variant 2 (ETV2) on the osteogenesis of human dental pulp stem cells.
    [Stem Cell Research & Therapy]

    Full Article

    New Mechanism for Mesenchymal Stem Cell Microvesicle to Restore Lung Permeability: Intracellular S1P Signaling Pathway Independent of S1P Receptor-1

    Investigators used the transwell co-culture system to study the effect of MSC microvesicle on protein permeability of lipopolysaccharide damaged human lung microvascular endothelial cells.
    [Stem Cell Research & Therapy]

    Full Article

    The Role of Notch Signaling in Endometrial Mesenchymal Stromal/Stem-Like Cells Maintenance

    The authors showed with gain- and loss-of-function experiments that activation of Notch signaling promoted endometrial MSC maintenance, while inhibition induced the opposite effect.
    [Communications Biology]

    Full Article

    Human Synovial Mesenchymal Stem Cells Show Time-Dependent Morphological Changes and Increased Adhesion to Degenerated Porcine Cartilage

    Scientists verified the adhesion of synovial MSCs to degenerated cartilage, the time course of that adhesion, and the morphological changes that MSCs underwent during the adhesion process.
    [Scientific Reports]

    Full Article

    COX-2/PGE2/VEGF Signaling Promotes ERK-Mediated BMSCs Osteogenic Differentiation under Hypoxia by the Paracrine Action of ECs

    The authors demonstrated that hypoxia promoted bone-marrow MSCs proliferation, colony formation, osteogenic markers expression, mineralization, and extracellular signal-regulated protein kinase phosphorylation.
    [Cytokine]

    AbstractGraphical Abstract

    IN VIVO

    Casticin Promotes Osteogenic Differentiation of Bone Marrow Stromal Cells and Improves Osteoporosis in Rats by Regulating Nuclear Factor-κB/Mitogen-Activated Protein Kinase

    A rat model of osteoporosis was established through dexamethasone treatment and a cell model reflecting the osteogenic and osteoclast induction was constructed in bone marrow stromal cells.
    [International Journal of Rheumatic Diseases]

    Abstract

    Mesenchymal Cell TRPM7 Expression Is Required for Bone Formation via the Regulation of Chondrogenesis

    Prx1-Cre-dependent Trpm7 mesenchymal-deleted mice were generated to examine the role of Transient receptor potential melastatin-subfamily member 7 (TRPM7) in bone development.
    [Bone]

    Abstract

    Intravenous Infusion of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tissue Perfusion in a Rat Hindlimb Ischemia Model

    Researchers tested whether an intravenous infusion of bone-marrow-derived MSCs improved tissue perfusion in a rat hindlimb ischemia model.
    [Scientific Reports]

    Full Article
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    REVIEWS

    Small Round Cell Sarcomas

    Emerging studies on the molecular mechanisms of small round cell sarcomas and the development of genetically engineered animal models hold promise for improvements in early detection, disease monitoring, treatment-related toxicity, overall survival, and quality of life.
    [Nature Reviews Disease Primers]

    Abstract

    Mesenchymal Stromal Cells for the Treatment of Alzheimer’s Disease: Strategies and Limitations

    Scientists focus on different clinical and preclinical studies using MSC as a therapy for treating Alzheimer’s disease, their outcomes, limitations, and the strategies to potentiate their clinical translation.
    [Frontiers in Molecular Neuroscience]

    Full Article
    INDUSTRY AND POLICY NEWS

    ISS National Lab Research Announcement Seeking Tissue Engineering and Biomanufacturing Proposals Opens

    The International Space Station (ISS) National Laboratory is specifically soliciting research concepts that seek to enhance tissue engineering and biomaterials that could be developed or manufactured in low Earth orbit.
    [ISS National Laboratory]

    Press Release
    FEATURED EVENT

    Frontiers in Cancer Science 2022

    November 7 – 9, 2022
    Singapore, Singapore

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    JOB OPPORTUNITIES

    Postdoctoral Position – Spatial Single-Cell Analysis of Human Bone Marrow

    University of Würzburg – Würzburg, Germany

    Postdoctoral Scholar – Stem Cell-Based Therapy

    UCLA Jules Stein Eye Institute – Los Angeles, California, United States

    Assistant/Associate Faculty Position – Cancer Research

    University of Colorado Denver – Aurora, Colorado, United States

    Research Professor – Tissue Regeneration Engineering

    Institute of Tissue Regeneration Engineering – Cheonan, South Korea

    Staff Scientist – Endometriosis

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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