 | | Vol. 14.41 – 18 October, 2022 |
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| Investigators reported the fast and standardized generation of human mini-bones by a custom-designed human mesenchymal cell line.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists investigated the feasibility of utilizing solubilized decellularized bone matrix (DBM) and nanohydroxyapatite-incorporated DBM hydrogels as an encapsulation matrix for bone marrow-derived MSCs.
[Journal of Biomedical Materials Research Part A] |
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| The authors assessed the effects of octenidine dihydrochloride on the proliferation, migration and induction of the osteogenic phenotype of stem cells from human dental pulp and apical papilla.
[Journal of Endodontics] |
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| Adipose-derived stromal cells (ADSCs) were treated with different concentrations of aloe polysaccharide and its effect on the processes of adipogenesis inhibition in ADSCs was analyzed.
[Molecular Biology Reports] |
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| CircFKBP5 expression was decreased in human dental pulp stem cells (hDPSCs) and, functionally, reexpression of circFKBP5 attenuated LPS-induced apoptosis, inflammation, and inhibition of proliferation ability and osteogenic differentiation in hDPSCs.
[International Dental Journal] |
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| Researchers developed a simple process for generating membrane vesicles directly from MSCs, which they referred to as synthetic eukaryotic vesicles.
[Journal of Nanobiotechnology] |
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| Scientists investigated the effect of MSC-exosomes (Exos) on glycolysis and the underlying mechanisms and demonstrated that MSC-Exos significantly ameliorated unilateral ureter obstruction-induced renal fibrosis.
[Cell Death & Disease] |
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| Investigators showed that MSCs restored the impaired autophagic flux and alleviated liver injuries in acute-on-chronic liver failure mice, but these effects were abolished when autophago-lysosomal maturation was inhibited by leupeptin.
[Cell Death & Disease] |
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| The authors demonstrated that systemic transplantation of MSCs improves healing of full-thickness vaginal incision in the vaginal wall of old rats, as suggested by both histological and functional analysis.
[Stem Cell Reports] |
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| Researchers investigated the role of calcium phosphate incorporation in a mechanically stable, biologically functional and 3D printable polymer for the reconstruction of complex craniofacial defects.
[Scientific Reports] |
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| The authors carry out an in-depth analysis to discuss the similarities and differences in materials, techniques, and purposes to standardize the methods aimed at obtaining adipose stem cells spheroids as already described for 2D cultures.
[Journal of Cellular Physiology] |
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| Investigators review the features of bone marrow MSC exosomes’ mechanism in osteogenesis and bone regeneration, and also the effects of their micro-RNAs on osteogenesis.
[Molecular Biology Reports] |
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| Salarius Pharmaceuticals, Inc. announced that, as per protocol design, it has voluntarily paused new patient enrollment in the company’s Phase I/II trial of seclidemstat as a treatment for Ewing sarcoma and FET-rearranged sarcomas.
[Salarius Pharmaceuticals, Inc.] |
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| November 14 – 17, 2022
Portland, Oregon, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | Eindhoven University of Technology – Eindhoven, Netherlands |
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| | University of Würzburg – Würzburg, Germany |
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| | UCLA Jules Stein Eye Institute – Los Angeles, California, United States |
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| | University of Colorado Denver – Aurora, Colorado, United States |
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