Mesenchymal Cell News Volume 14.43 | Nov 1 2022

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    2022-11-01 | MESCN 14.43


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 14.43 – 1 November, 2022
    TOP STORY

    Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells

    Researchers uncovered the dual roles of NG2+ cells in metastasis and remodeling, and indicated that osteo-differentiation of bone MSCs promoted metastasis initiation.
    [Cancer Discovery]

    AbstractPress Release
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    PUBLICATIONSRanked by the impact factor of the journal

    Cell-Taxi: Mesenchymal Cells Carry and Transport Clusters of Cancer Cells

    Scientists developed an in vitro platform based on inverted-pyramidal microwells to follow and quantify the collective migration of hundreds of tumor cell clusters.
    [Small]

    Abstract

    The Synergistic Regulation of Chondrogenesis by Collagen-Based Hydrogels and Cell Co-Culture

    MSCs and chondrocytes were co-cultured or monocultured in collagen, CMA30 and CMA80 hydrogels in vitro or in vivo.
    [Acta Biomaterialia]

    AbstractGraphical Abstract

    LncRNA XIST from the Bone Marrow Mesenchymal Stem Cell Derived Exosome Promotes Osteosarcoma Growth and Metastasis through miR-655/ACLY Signal

    MSCs derived exosomes were used to treat human osteosarcoma cells MG63 and 143B, and the level of X-inactive specific transcript (XIST) in bone marrow MSCs was intervened by siRNA.
    [Cancer Cell International]

    Full Article

    Mesenchymal Stem Cells Encapsulation in Chitosan and Carboxymethyl Chitosan Hydrogels to Enhance Osteo-Differentiation

    Investigators designed and developed biocompatible and bioactive hydrogels for osteo-tissue regeneration based on the natural polysaccharide chitosan.
    [Molecular Biology Reports]

    Abstract

    miR-30a Inhibits the Osteogenic Differentiation of the Tibia-Derived MSCs in Congenital Pseudarthrosis via Targeting HOXD8

    Congenital pseudarthrosis of the tibia-derived MSCs showed a lower ability of osteogenic differentiation than normal MSCs.
    [Regenerative Therapy]

    Full Article

    Sutureless Transplantation of In Vivo Priming Human Mesenchymal Stem Cell Sheet Promotes the Therapeutic Potential for Cardiac Repair

    Researchers demonstrated a novel way for a comprehensive cardiac repair achieved by the sutureless transplantation of a highly integrable in vivo priming bone marrow MSC sheet.
    [Biofabrication]

    Abstract

    Human Adipose- and Amnion-Derived Mesenchymal Stromal Cells Similarly Mitigate Osteoarthritis Progression in the Dunkin Hartley Guinea Pig

    Scientists compared the ability of intra-articularly injected adipose-derived MSCs and amnion-derived MSCs to mitigate the progression of knee osteoarthritis (OA) in a small animal model of spontaneous OA.
    [American Journal of Sports Medicine]

    Abstract

    Intra-Articular Injections of the Adipose-Derived Mesenchymal Stem Cells Suppress Progression of a Mouse Traumatic Knee Osteoarthritis Model

    The authors determined whether the intra-articular injection of human adipose-derived MSCs protected against the progression of murine post-traumatic osteoarthritis.
    [Cartilage]

    Full Article
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    REVIEWS

    Cellular and Molecular Targets of Extracellular Vesicles from Mesenchymal Stem/Stromal Cells in Rheumatoid Arthritis

    Investigators discuss the anti-arthritic effects of MSC extracellular vesicles in vitro and in animal models of rheumatoid arthritis as well as their potential mechanisms.
    [Stem Cells Translational Medicine]

    Full ArticleGraphical Abstract

    Potential of Mesenchymal Stem Cell-Based Therapies for Pulmonary Fibrosis

    Scientists review recently published data on MSC administration for the treatment of pulmonary fibrosis to provide insights into the therapeutic impact of MSC delivery procedures and sources.
    [DNA and Cell Biology]

    Abstract
    INDUSTRY AND POLICY NEWS

    China’s Space Station Is Almost Complete — How Will Scientists Use It?

    China’s space station Tiangong will host more than 1,000 experiments over a decade, including attempts to reproduce results from the International Space Station.
    [Nature]

    Press Release
    FEATURED EVENT

    2022 San Antonio Breast Cancer Symposium

    December 6 – 10, 2022
    San Antonio, Texas, United States

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    JOB OPPORTUNITIES

    Postdoctoral Position – Joint and Articular Cartilage Homeostasis

    Harvard Medical School – Boston, Massachusetts, United States

    Postdoctoral Scientist – Cancer Regulators

    University of Texas Health Science Center at Houston – Houston, Texas, United States

    Postdoctoral Position – Oral Immunology and Tissue Degenerative Processes

    Ume̴, Sweden РUme̴ University

    Postdoctoral Researcher – Childhood Oncology

    Karolinska Institutet – Solna, Sweden

    Research Assistant – Sarcoma

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    > See All Jobs

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