 | | Vol. 14.44 – 8 November, 2022 |
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| Scientists used sulfated alginate hydrogels loaded with mesenchymal spheroids to aid in the regeneration of a rat muscle crush injury.
[Acta Biomaterialia] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The viability, migration, and invasion of osteosarcoma cells were inhibited by knockdown of SIRT2 and were enhanced by overexpression of SIRT2.
[Cell Death & Disease] |
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| Investigators explored the immunomodulatory effect of paeoniflorin in MSCs and the potential involvement of Th1/Th2 cytokines in oral lichen planus.
[Scientific Reports] |
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| The authors identified the effect of donor age on the chondrogenic and osteogenic differentiation performance of equine bone marrow- and adipose tissue-MSCs in vitro.
[BMC Veterinary Research] |
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| Investigators found that cells on plates coated with ECM proteins had much higher proliferation compared to the regular tissue culture plates.
[Tissue and Cell] |
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| Notch1-induced T cell acute lymphoblastic leukemia (T-ALL) mice models were used and dynamic alterations of bone marrow-MSCs with increased cell viability during T-ALL development were observed.
[Cell Death & Disease] |
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| Researchers reported that endogenous MSCs mobilized into the circulation at day 5 post myocardial infarction in male Lewis rats.
[Disease Models & Mechanisms] |
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| To clarify the mechanism involved in effects of MSCs on rheumatoid arthritis (RA), proteomic profiling was performed using an RA mouse model before and after treatment with MSCs.
[PLoS One] |
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| Researchers studied the effect of MSC on skin wound healing and utilized an experimental murine model of full-thickness wounds. Wounds were treated with human bone marrow-MSC contained in a platelet-rich plasma clot.
[Archives of Dermatological Research] |
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| Scientists discuss the characteristics and functions of MSCs under different pathophysiological conditions and highlight how the immunomodulatory functions of MSCs are altered in accordance with the inflammatory cues.
[Cell Stem Cell] |
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| The author outlines the current views on MSCs in the thymus, particularly highlighting the newly discovered function of thymic fibroblasts in T cell repertoire selection.
[Inflammation and Regeneration] |
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| Cynata Therapeutics Limited announced that the Leiden University Medical Center (LUMC) is funding an important clinical trial to investigate Cynata’s Cymerus™ MSCs as a treatment for renal graft rejection and to potentially reduce the requirement for anti-rejection drugs.
[Cynata Therapeutics Limited] |
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| The US FDA had set out proposals for the New Alternative Methods Program that will focus on replacing, reducing, and refining the use of laboratory animals through the adoption of cutting-edge alternative methods.
[Nature News] |
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| January 22 – 25, 2022
Santa Fe, New Mexico, United States |
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| | Institute for Tumor Biology and Experimental Therapy – Frankfurt, Germany |
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| | NUI Galway – Galway, Ireland |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | UC San Francisco – San Francisco, California, United States |
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| | University of Texas Health Science Center at Houston – Houston, Texas, United States |
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