 | | Vol. 14.46 – 22 November, 2022 |
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| Investigators drew a large-scale single-cell transcriptomic atlas and identified three clusters, representing the primed, intermediate, and stem statuses within human umbilical cord-derived-MSCs individually.
[Advanced Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| MSC-derived nanovesicles acted as an extracellular vesicle (EV)-mimetic, by accelerating wound healing in vitro and in vivo at a similar rate as EVs and whole MSC cells used as controls, thus paving the way for promising, scalable regenerative approaches.
[Acta Pharmaceutica Sinica B] |
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| Investigators characterized the molecular mechanism of the anti-fibrotic activity of histone deacetylase 1 (HDAC1) inhibition, focusing on the regulation of miRNAs previously described to exert an anti-fibrotic activity.
[Cell Death & Disease] |
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| Researchers explored the effects and mechanisms of the interaction between Lnc Tmem235 and miR-34a-3p on hypoxia-induced apoptosis of bone marrow MSCs.
[Experimental & Molecular Medicine] |
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| Investigators explored whether graphene-modified polyetheretherketone could improve cell adhesion and osteogenic differentiation.
[International Journal of Nanomedicine] |
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| Scientists investigated the effects of green LED irradiation, retinoic acid, and their combination on the differentiation of human umbilical cord matrix-derived mesenchymal cells into neural lineage as well as the mechanisms involved.
[Biochemical and Biophysical Research Communications] |
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| Researchers showed that the depletion of CD206+ M2-like macrophages (MΦ) promoted skeletal muscle regeneration, as well as that depletion of CD206+ M2-like MΦ during the early phase of repair considerably accelerated the recovery of the injured skeletal muscle through activation of fibroadipogenic progenitors.
[Nature Communications] |
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| Scientists determined the effect of human umbilical cord-derived mesenchymal stem cells on asthmatic lungs by modulating innate immune cells and effector T cells using a murine asthmatic model.
[Molecular and Cellular Biology] |
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| Investigators focused on the preventative effects of a novel active vitamin D3 analog, eldecalcitol, against glucocorticoid-induced osteoporosis and explored the underlying molecular mechanisms.
[Drug Design Development and Therapy] |
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| Scientists established a protocol for the induction of advanced liver fibrosis in rats using thioacetamide, which allowed them to perform trials using MSC as a possible therapy for fibrosis regression.
[Analytical Cellular Pathology] |
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| The authors review the specific mechanism of MSCs to facilitate spinal cord injury (SCI) repair, but also further discuss the research status of these pluripotent stem cells combined with other therapeutic approaches to promote anatomical and functional recovery post-SCI.
[Biomedicine & Pharmacotherapy] |
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| TRACON Pharmaceuticals, Inc. announced the dosing of the first patient in a Phase I/II trial evaluating the Company’s CTLA-4 antibody, YH001, in combination with its PD-L1 antibody envafolimab and with doxorubicin in front line therapy in patients with sarcoma.
[Tracon Pharmaceuticals, Inc.] |
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| RHEACELL was honored by the organization ‘Dystrophic Epidermolysis Bullosa ResearchAssociation of America’ (debra) with the ‘Partners in Progress Award’, recognizing RHEACELL’s research commitment and medical advancements in the development of a therapy for the treatment of severe forms of Epidermolysis Bullosa.
[RHEACELL] |
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| December 4 – 7, 2022
Banff, Alberta, Canada |
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| | Uppsala University – Uppsala, Sweden |
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| | City of Hope – Los Angeles, California, United States |
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| | Institut Curie – Paris, France |
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| | Cancer Research UK Manchester Institute – Manchester, England, United Kingdom |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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