 | | Vol. 14.48 – 6 December, 2022 |
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| Scientists discovered LNA043, a derivative of angiopoietin-like 3, as a potent chondrogenesis inducer using a phenotypic screen with human mesenchymal stem cells.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators designed a “bead-jet” printer, specialized for high-throughput intra-operative formulation and printing of MSCs-laden Matrigel beads.
[Nature Communications] |
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| Researchers demonstrated that prospero-related homeobox 1 (PROX1) was needed for rhabdomyosarcoma cell clonogenicity, growth, and tumor formation.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors constructed an in vitro matrix of multivariate readouts to identify putative critical quality attributes that could discriminate between specific critical processing parameters chosen for their ability to enhance MSC immunomodulatory and angiogenic potencies.
[Frontiers in Immunology] |
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| In vitro experiments demonstrated that adipose-derived MSCs co-cultured with alveolar epithelial cells depended on autophagy for significant anti-inflammatory functions.
[Cell Death Discovery] |
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| MSCs were exposed to different concentrations of H2O2, and the optimal H2O2 pretreatment conditions were determined by evaluating their critical cell functional properties.
[Scientific Reports] |
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| Researchers investigated the potential therapeutic mechanism of miR‐27a on steroid-induced osteonecrosis of the femoral head.
[Scientific Reports] |
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Scientists explored the impact of shikonin on the osteogenic differentiation of bone marrow stromal cells in vitro and further analyzed the potential mechanisms using an inhibitor of p38 MAPK.
[Odontology] |
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| Researchers evaluated the impact of umbilical cord-derived MSCs and bone marrow-derived MSCs in terms of pro-angiogenic capacity and amelioration of pregnancy outcomes.
[In Vitro Cellular & Developmental Biology – Animal] |
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| The authors discuss the recent advances in our understanding of the pathogenic role of MSCs in regulating tumor initiation, progression, and metastasis, thus providing a strong rationale for targeting MSCs in cancer therapy.
[Archives of Medical Research] |
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| Investigators summarize the currently available knowledge regarding the immunopathogenic mechanisms involved in vitiligo and the progress achieved in MSC-based therapy.
[Transplant Immunology] |
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| After weeks of strikes and negotiating involving thousands of early-career researchers across the University of California (UC) system, the union representing UC postdocs and academic researchers announced it has reached a tentative agreement with administrators.
[Science Careers] |
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| January 24 – 26, 2023
Boston, Massachusetts, United States |
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| | Max Delbrück Center for Molecular Medicine – Berlin-Buch, Germany |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | City of Hope – Los Angeles, California, United States |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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