 | | Vol. 14.49 – 13 December, 2022 |
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| In breast cancer models, researchers found lung-resident mesenchymal cells accumulating neutral lipids at the pre-metastatic stage.
[Cell Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists developed a facile approach to fabricate a bionic scaffold perfectly combining bone extracellular matrix (ECM)-like microenvironment and robust mechanical properties.
[ACS Nano] |
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| Investigators explored the protective role of aspirin against the negative effects of tumor necrosis factor alpha on bone marrow MSCs chondrogenesis.
[Cell Proliferation] |
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| The authors found that the mitochondria derived from endometrial MSCs could significantly improve the quality of aged oocytes.
[Cell Proliferation] |
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| Investigators demonstrated that MSCs transfer mitochondria to stressed chondrocytes in cell culture and in injured cartilage tissue.
[Scientific Reports] |
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| Scientists used forskolin, an adenylate cyclase agonist and cyclic adenosine monophosphate (cAMP) inducer, to disrupt metabolism in human adipose-derived MSCs and investigate the effects of metabolic dysfunction on MSC senescence.
[Stem Cells and Development] |
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| The authors examined whether diabetic serum free fatty acids influenced the viability, differentiation, and fatty acid composition of the major lipid fractions of human adipose tissue-derived MSCs in vitro.
[Applied Biochemistry and Biotechnology] |
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| To determine if exogenous interleukin-2 (IL-2) in the tumor microenvironment could overcome immune checkpoint blockade resistance, researchers engineered MSCs to successfully deliver IL-2 mutein dimer to tumor-infiltrating lymphocytes.
[Nature Cell Biology] |
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| Scientists investigated the combinatorial effect of human MSCs and extracellular vesicles on cartilage regeneration via co-encapsulation in a hyaluronic-acid-based hydrogel.
[Journal of Tissue Engineering and Regenerative Medicine] |
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| The authors describe the current state of preclinical spheroid research and highlight two key examples of spheroid use in clinically relevant disease modeling.
[npj Regenerative Medicine] |
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| Investigators discuss the main mesenchymal cell populations of the prostate stroma, highlighting their dynamic role in the transition of the healthy prostate epithelium to cancer.
[British Journal of Cancer] |
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| Calidi Biotherapeutics, Inc. announced that the CIRM has awarded the company a $3.1 million grant to support the continued development of the company’s Supernova-1 pre-clinical program through an Investigational New Drug application.
[Calidi Biotherapeutics, Inc.] |
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| February 13 – 16, 2023
Breckenridge, Colorado, United States |
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| | German Cancer Research Center in the Helmholtz Association – Essen, Germany |
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| | Flanders Institute for Biotechnology – Leuven, Belgium |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Max Delbrück Center for Molecular Medicine – Berlin-Buch, Germany |
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