Mesenchymal Cell News Volume 15.01 | Jan 10 2023

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    2023-01-10 | MESCN 15.01


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.01 – 10 January, 2023
    TOP STORY

    Mesenchymal Stem Cell-Derived Extracellular Vesicles Transfer miR-598 to Inhibit the Growth and Metastasis of Non-Small-Cell Lung Cancer by Targeting THBS2

    Scientists defined the role of MSCs-derived extracellular vesicles (EVs) containing miR-598 in non-small-cell lung cancer (NSCLC). Co-culture experiments were conducted to examine the secretion of miR-598 by MSCs and the uptake of EVs by NSCLC cells.
    [Cell Death Discovery]

    Full Article
    Virtual Conference Exhibition: Pluripotent Stem Cells
    PUBLICATIONSRanked by the impact factor of the journal

    Delivery of Immobilized IFN-γ with PCN-333 and Its Effect on Human Mesenchymal Stem Cells

    Researchers synthesized the metal–organic framework PCN-333(Fe) and showed that it could be utilized to immobilize and deliver interferon-gamma (IFN-γ) to the local extracellular environment of human MSCs.
    [Acs Biomaterials Science & Engineering]

    AbstractGraphical Abstract

    Subtle Changes in Perivascular Endometrial Mesenchymal Stem Cells after Local Endometrial Injury in Recurrent Implantation Failure

    Investigators assessed the effect of local endometrial injury (LEI) on the proportion and function of endometrial MSCs present in consecutive LEI biopsies.
    [Scientific Reports]

    Full Article

    In Situ Forming Injectable GFOGER-Conjugated BMSCs-Laden Hydrogels for Osteochondral Regeneration

    In vitro experiments using rat bone marrow-derived MSCs revealed that the GFOGER-methoxy polyethylene glycol-b-polycaprolactone hydrogel significantly enhanced expression of integrins, increased expression of FAK, and induced downstream signaling of ERK and p38.
    [Npj Regenerative Medicine]

    Full Article

    Human Platelet Lysate Enhances Proliferation but Not Chondrogenic Differentiation of Pediatric Mesenchymal Progenitors

    Scientists showed that auricular cartilage stem/progenitor cells and adipose-derived stem cells displayed greater proliferation rate in human platelet lysate than fetal bovin serum and expressed typical MSC surface antigens in both media.
    [Cytotherapy]

    Abstract

    Comparative Analysis of Mesenchymal Stem/Stromal Cells Derived from Human Induced Pluripotent Stem Cells and the Cognate Umbilical Cord Mesenchymal Stem/Stromal Cells

    Researchers successfully reprogrammed human umbilical cords-derived MSCs into induced-pluripotent stem cells by using the cocktails of mRNA.
    [Heliyon]

    Full Article

    Therapeutic Effects of hAMSCs Secretome on Proliferation of MDA-MB-231 Breast Cancer Cells by the Cell Cycle Arrest in G1/S Phase

    The authors explored the therapeutic effects of human amniotic MSCs secretome on breast cancer cells, MDA-MB-231, through analyzing cell cycle progression.
    [Clinical And Translational Oncology]

    Abstract

    Galangin Inhibits Lipopolysaccharide-Induced Inflammation and Stimulates Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells via Regulation of AKT/mTOR Signaling

    Galangin exerted an anti-inflammatory effect against lipopolysaccharide- stimulated bone marrow MSCs and promoted osteogenic differentiation through the activation of AKT/ mTOR signaling.
    [Allergologia Et Immunopathologia]

    Abstract

    EGFL7 Secreted by Human Bone Mesenchymal Stem Cells Promotes Osteoblast Differentiation Partly via Downregulation of Notch1-Hes1 Signaling Pathway

    A femoral defect model was established to verify the effect of recombinant mouse EGFL7 on bone healing in vivo. EGFL7 promoted osteogenesis of human bone marrow MSCs partly via downregulation of Notch1 signaling.
    [Stem Cell Reviews And Reports]

    AbstractGraphical Abstract
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    REVIEWS

    Mesenchymal Stem Cell Derived Extracellular Vesicles: Promising Nanomedicine for Cutaneous Wound Treatment

    The authors provide critical comments on current advances in extracellular vesicles derived from mesenchymal stem cells for wound repair, elaborating on their roles in eliminating infections, inhibiting inflammation, promoting angiogenesis, and reducing scar formation.
    [Acs Biomaterials Science & Engineering]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    BrainStorm Cell Therapeutics Partners with NEALS, the ALS Association, and I AM ALS to Provide Public Access to Biospecimens from NurOwn’s Phase III ALS Study

    BrainStorm Cell Therapeutics, Inc. announced that BCLI will donate biospecimens from NurOwn’s placebo-controlled Phase III ALS trial to the Northeast Amyotrophic Lateral Sclerosis Consortium (NEALS) biorepository for use by the research community.
    [BrainStorm Cell Therapeutics, Inc.]

    Press Release
    FEATURED EVENT

    ESMO Targeted Anticancer Therapies Congress 2023

    March 6 – 8, 2023
    Paris, France

    > See All Events

    JOB OPPORTUNITIES

    Adult Medical Oncologist – Sarcoma Program

    Johns Hopkins University – Baltimore, Maryland, United States

    Postdoctoral Position – Computational Biology

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Postdoctoral Position – Tissue Regeneration Engineering

    Dankook University – Seoul, South Korea

    PhD Position – Precision Sarcoma Research

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Postdoctoral Fellow – Osteoarthritis

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    > See All Jobs

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