Mesenchymal Cell News Volume 15.04 | Jan 31 2023

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    2023-01-31 | MESCN 15.04


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.04 – 31 January, 2023
    TOP STORY

    Enrichment of Oral-Derived Bacteria in Inflamed Colorectal Tumors and Distinct Associations of Fusobacterium in the Mesenchymal Subtype

    Across consensus molecular subtypes (CMSs), integration of Fusobacterium animalis (Fa) presence and tumor expression reveals that Fa has the most significant associations in mesenchymal CMS4 tumors despite a lower prevalence than in immune CMS1.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Transfer of Mesenchymal Stem Cell Mitochondria to CD4+ T Cells Contributes to Repress Th1 Differentiation by Downregulating T-bet Expression

    Scientists utilized CD4+ T cells from HNT TCR transgenic mice that developed Th1-like responses upon antigenic stimulation in vitro and in vivo.
    [Stem Cell Research & Therapy]

    Full Article

    Mesenchymal Stem Cell-Derived Exosomes Ameliorate Diabetic Kidney Disease through the NLRP3 Signaling Pathway

    Investigators co-cultured podocytes and human umbilical cord-MSCs derived exosomes (Exo) under high glucose and injected MSCs-Exo into diabetic mice, then detected the NLRP3 inflammasome both in vitro and in vivo.
    [Stem Cells]

    Abstract

    Graphical Abstract

    Development of Hetero-Cell Type Spheroids via Core–Shell Strategy for Enhanced Wound Healing Effect of Human Adipose-Derived Stem Cells

    Researchers developed a core–shell structured spheroid with adipose-derived stem cells in the core and human dermal fibroblasts in the outer part of the spheroid. The core–shell structure was formed by continuous centrifugation and spheroid incubation.
    [Tissue Engineering and Regenerative Medicine]

    Abstract

    Extracellular Vesicles from Hypoxia-Pretreated Adipose-Derived Stem Cells Regulate Hypoxia/Reoxygenation-Induced Human Dermal Microvascular Endothelial Apoptosis and Autophagy In Vitro

    Scientists investigated the effect of exracellular vesicles isolated from hypoxia-pretreated adipose-derived stem cells on human dermal microvascular endothelial cells to attenuate ischemia/reperfusion injury of free skin flaps.
    [Heliyon]

    Full Article

    Interleukin-18-Primed Human Umbilical Cord-Mesenchymal Stem Cells Achieve Superior Therapeutic Efficacy for Severe Viral Pneumonia via Enhancing T-Cell Immunosuppression

    Researchers selected an appropriate cytokine, IL-18, based on the special cytokine expression profile in severe pneumonia of mice induced by H1N1virus to prime human umbilical cord (hUC)-MSCs in vitro and improved the therapeutic effect of hUC-MSCs in vivo.
    [Cell Death & Disease]

    Full Article

    Exosomes Derived from Human Adipose Mesenchymal Stem Cells Ameliorate Hepatic Fibrosis by Inhibiting PI3K/Akt/mTOR Pathway and Remodeling Choline Metabolism

    The authors investigated anti-fibrotic efficacy of exosomes derived from human adipose MSCs in vitro and in vivo, and identified important metabolic changes and the detailed mechanism through transcriptomic and metabolomic profiling.
    [Journal Of Nanobiotechnology]

    AbstractGraphical Abstract

    Exosomes Derived from Human Amniotic Mesenchymal Stem Cells Facilitate Diabetic Wound Healing by Angiogenesis and Enrich Multiple lncRNAs

    The effect of exosomes derived from human amniotic MSCs on diabetic wound healing were tested by measuring wound closure rates and immunohistochemical staining of CD31.
    [Tissue Engineering And Regenerative Medicine]

    Abstract

    A Clinical Feasible Stem Cell Encapsulation Ensures an Improved Wound Healing

    The authors developed a novel biosynsphere technology to encapsulate stem cells in clinically-ready biomaterials with controlled microsphere size.
    [Biomedical Materials]

    Abstract
    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    REVIEWS

    Stromal Regulation of the Intestinal Barrier

    Investigators review novel findings on the emerging role of mesenchymal cells in the process of development and maintenance of a functional intestinal barrier using insights gained from lineage tracing approaches, Cre-based genes deletion and single cells transcriptomics.
    [Mucosal Immunology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Bone Biologics Advances Preparations for NB1 Pilot Clinical Trial with Engagement of Contract Research Organization

    Bone Biologics Corporation announced it has engaged Avania as the contract research organization for the company’s pilot clinical trial with NB1.
    [Bone Biologics Corporation (BusinessWire, Inc.)]

    Press Release
    FEATURED EVENT

    EBMT 49th Annual Meeting

    April 23 – 26, 2023
    Paris, France

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Fibro/Adipogenic Progenitors

    University of Florida – Gainesville, Florida, United States

    Assistant Professor – Stem Cells and Regenerative Medicine

    The Ottawa Hospital – Ottawa, Ontario, Canada

    Research Associate – Regenerative Therapies

    Dresden University of Technology – Dresden, Germany

    Postdoctoral Fellow – Cancer Biology

    City of Hope – Duarte, California, United States

    Postdoctoral Scholar Positions – Stem Cell-Based Therapy

    UCLA Jules Stein Eye Institute – Los Angeles, California, United States

    > See All Jobs

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