 | | Vol. 15.05 – 7 February, 2023 |
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| Researchers demonstrated that gastrointestinal mesenchymal cells control epithelial fate and function through Polycomb Repressive Complex 2-mediated chromatin bivalency.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| By performing whole-genome sequencing of matched cell-free DNA and osteosarcoma tissue samples, the authors investigated the correlation between the size and mutation profiles of cfDNA and the mutation concordance between cfDNA and paired tissue tumors.
[Clinical Cancer Research] |
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| Loading paclitaxel in MSCs resulted in increased levels of mitochondrial reactive oxygen species. In response to this oxidative stress, MSCs upregulated two important set of proteins.
[Materials Today Bio] |
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| Using scRNAseq, the authors aimed to delineate the cellularheterogeneity of this MSC-enriched population throughout development.
[Hemasphere] |
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| Scientists investigated the hair growth-promoting effects of human embryonic stem cell-MSCs and their underlying mechanisms.
[Biomedicine & Pharmacotherapy] |
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| Bone marrow-derived stromal cells were encapsulated in type I collagen hydrogels and mechanically stimulated using low intensity pulsed ultrasound-derived acoustic radiation force.
[Journal Of Biomedical Materials Research Part A] |
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| Compared to naïve cells, bone marrow-MSCs phosphatase of regenerating liver-1 (PRL-1) showed an improved antioxidant capacity and mitochondrial dynamics, as well as decreased cellular senescence.
[Molecular Therapy – Nucleic Acids] |
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| Investigators extracted and purified bone marrow MSCs from SD rats. A chronic obstructive pulmonary (COPD) apoptosis model was established by cigarette smoke exposure.
[Apoptosis] |
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| Scientists determined the effect of human dental pulp stem cell on the imiquimod-induced psoriasis in mice. The psoriasis model was established by topical application of imiquimod cream in mice for seven days.
[Heliyon] |
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| The authors discuss recent progress in preclinical and clinical studies and current challenges in MSCs-based therapies in acute liver failure, with a special focus on in vivo reports.
[Stem Cell Research & Therapy] |
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New advanced methods have been developed to upscale MSC cultivation and extracellular vesicles production yields, ranging from new cell culture devices to priming procedures.
[Trends In Biotechnology] |
| | The authors summarize recent advances in the use of MSC for the treatment of obesity-associated diseases to support the hypothesis that adipokines modulate the benefits of MSC therapy in obese patients.
[Experimental & Molecular Medicine] |
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| Celularity, Inc. announced that the FDA has reviewed information provided by the Company and other relevant available information, and agreed with the Company’s recommendation that its investigational CTW product be regulated as a device by the FDA Center for Devices and Radiologic Health.
[Celularity, Inc.] |
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| April 17 – 19, 2023
Lund, Sweden |
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| | Weill Cornell Graduate School of Medical Sciences – New York, New York, United States |
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| | Fred Hutchinson Cancer Center – Seattle, Washington, United States |
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| | University of Florida – Gainesville, Florida, United States |
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| | Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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| | Dresden University of Technology – Dresden, Germany |
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