Mesenchymal Cell News Volume 15.07 | Feb 28 2023

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    2023-02-28 | MESCN 15.07


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.07 – 28 February, 2023
    TOP STORY

    A Population of Stem Cells with Strong Regenerative Potential Discovered in Deer Antlers

    The authors described a single-cell atlas of antler regrowth. The earliest-stage antler initiators were mesenchymal cells that expressed the paired related homeobox 1 gene.
    [Science]

    Abstract
    STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.
    PUBLICATIONSRanked by the impact factor of the journal

    Enhancer Co-Amplification and Hijacking Promote Oncogene Expression in Liposarcoma

    Investigators reported a comprehensive molecular characterization of both tumor and normal tissues from the same liposarcoma patients, including whole genome sequencing, transcriptome, enhancer landscape, and genome-wide 3D genome structure by Hi-C.
    [Cancer Research]

    Abstract

    Extended Preconditioning on Soft Matrices Directs Human Mesenchymal Stem Cell Fate via YAP Transcriptional Activity and Chromatin Organization

    Scientists discovered that extended preconditioning on soft matrices led to approximately a 1/3 decrease in cell spreading, a 2/3 decrease in osteogenic markers of hMSCs, and a 1/13 decrease in the production of mineralized nodules.
    [APL Bioengineering]

    Full Article

    Robust Protein-Based Engineering of Hepatocyte-Like Cells from Human Mesenchymal Stem Cells

    Engineered MSCs were subjected to epigenetic analysis, biochemical analysis, and flow cytometry analysis with antibodies to marker proteins of mature hepatocytes and hepatic progenitors such as delta-like homolog 1 and trophoblast cell surface antigen 2.
    [Hepatology Communications]

    Full Article

    Enhanced Bone Tissue Regeneration Using a 3D-Printed Poly(lactic Acid)/Ti6Al4V Composite Scaffold with Plasma Treatment Modification

    Utilizing a material extrusion technique, 3D PLA-Ti6Al4V scaffolds with open pores and interconnected channels were successfully fabricated.
    [Scientific Reports]

    Full Article

    Randomized Trial of Targeted Transendocardial Mesenchymal Precursor Cell Therapy in Patients with Heart Failure

    This randomized, double-blind, multicenter study evaluated a single transendocardial administration procedure of mesenchymal precursor cells or sham-control in 565 intention-to-treat patients with heart failure with reduced ejection fraction on guideline-directed therapies.
    [Journal Of The American College Of Cardiology]

    Full ArticlePress ReleaseGraphical Abstract

    The 3D-Printed Ordered Bredigite Scaffold Promotes Pro-Healing of Critical-Sized Bone Defects by Regulating Macrophage Polarization

    Physicochemical properties of Bredigite and β-tricalcium phosphate scaffolds and were characterized, and RAW 264.7 cells, bone marrow MSCs, and rat cranial critical-sized bone defect models were utilized for evaluating macrophage polarization and bone regeneration.
    [International Journal Of Nanomedicine]

    Full ArticleGraphical Abstract

    Nanowarming and Ice-Free Cryopreservation of Large Sized, Intact Porcine Articular Cartilage

    Investigators developed a nanowarming and ice-free cryopreservation method for large sized, intact articular cartilage preservation. The method achieved a heating rate of 76.8°C min-1M, over one order of magnitude higher than convection warming
    [Communications Biology]

    Full Article

    Impact of Umbilical Cord Mesenchymal Stromal/Stem Cell Secretome and Cord Blood Serum in Prostate Cancer Progression

    Researchers investigated the influence of umbilical cord-MSC secretome and cord blood serum on two human prostate cancer cell lines and a normal epithelial prostate cell line.
    [Human Cell]

    Full ArticleGraphical Abstract

    AdipoRon Accelerates Bone Repair of Calvarial Defect in Diet-Induced Obesity Mice

    Scientists investigated the role of AdipoRon in bone wound healing of calvaria critical-sized defects in diet-induced obesity mice.
    [Heliyon]

    Full ArticleGraphical Abstract
    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTectâ„¢ CRISPR-Cas9 System.
    REVIEWS

    Mesenchymal Stromal Cells in Hepatic Fibrosis/Cirrhosis: From Pathogenesis to Treatment

    The authors examine the controversial role of mesenchymal stromal cells in the pathogenesis and treatment of hepatic fibrosis/cirrhosis.
    [Cellular & Molecular Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Professor Molly Stevens wins 2023 Novo Nordisk Prize

    Professor Molly Stevens has won the 2023 Novo Nordisk Prize for her pioneering work in innovative bioengineering approaches.
    [Imperial College London]

    Press Release
    FEATURED EVENT

    Autophagy and Neurodegeneration: Mechanisms to Therapies

    March 26 – 29, 2023
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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cartilage Regeneration

    University Medical Center Utrecht – Utrecht, Netherlands

    Research Officer – Bioinformatics

    The University of Melbourne – Melbourne, Australia

    Research Assistant – Immunotherapy for Intervertebral Disc Degeneration

    National University of Singapore – Singapore, Singapore

    Associate Professor – Biomedical Engineering

    Khalifa University – Abu Dhabi, United Arab Emirates

    Associate Professor – Biomedical Engineering

    Khalifa University – Abu Dhabi, United Arab Emirates

    > See All Jobs

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