Mesenchymal Cell News Volume 15.08 | Mar 7 2023

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    2023-03-07 | MESCN 15.08


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.08 – 7 March, 2023
    TOP STORY

    Cartilage Lacuna-inspired Microcarriers Drive Hyaline Neocartilage Regeneration

    The authors reported specially designed lacunar hyaluronic acid microcarrier with mechanotransductive conditions that rapidly form stable hyaluronic acid N-hydroxy succinimide ester.
    [Advanced Materials]

    Abstract
    PUBLICATIONSRanked by the impact factor of the journal

    Comparison of Exosomes Secreted by Synovial Fluid-Derived Mesenchymal Stem Cells and Adipose Tissue-Derived Mesenchymal Stem Cells in Culture for microRNA-127-5p Expression during Chondrogenesis

    Synovial fluid-derived MSCs, adipose tissue-derived MSCs, and human fetal chondroblast cells were directed to chondrogenic differentiation.
    [Gene]

    Full ArticleGraphical Abstract

    Mesenchymal Stem Cell-Derived Neural Progenitors Attenuate Proinflammatory Microglial Activation via Paracrine Mechanisms

    Microglia were stimulated in the presence of MSC-derived neural progenitor cell-conditioned media, and proinflammatory or proregenerative marker expression was assessed by quantitative PCR and ELISA.
    [Regenerative Medicine]

    Full ArticleGraphical Abstract

    NAT10 Promotes Osteogenic Differentiation of Periodontal Ligament Stem Cells by Regulating VEGFA-Mediated PI3K/AKT Signaling Pathway through ac4C Modification

    Osteogenic, adipogenic, and chondrogenic differentiation potential was detected by alizarin red staining, oil red O staining, and Alcian blue staining. Alkaline phosphatase activity was assessed by ALP assay.
    [Odontology]

    Full Article

    Urine-Derived Mesenchymal Stem Cells-Derived Exosomes Enhances Survival and Proliferation of Aging Retinal Ganglion Cells

    Primary urine-derived MSCs (USCs) were cultured and identified by immunofluorescence staining. Aging retinal ganglion cell models were established by D-galactose treatment and identified by β-Galactosidase staining.
    [BMC Molecular And Cell Biology]

    Full Article

    Sulfasalazine and Chromotrope 2B Reduce Oxidative Stress in Murine Bone Marrow-Derived Mesenchymal Stem Cells

    Researchers evaluated two antioxidant compounds; Chromotrope 2B and Sulfasalazine, for their antioxidant effects on young and old rat bone marrow MSCs.
    [Molecular Biology Reports]

    Abstract

    TGM2 Accelerates Migration and Differentiation of BMSCs by Activating Wnt/β-Catenin Signaling

    The study was developed to reveal the impact of transglutaminase 2 on the migration and differentiation of bone marrow MSCs. Cells were isolated from bone marrow of mice and then the surface antigens were identified by flow cytometry.
    [Journal Of Orthopaedic Surgery And Research]

    Full Article

    Fabrication and Multiscale Modeling of Polycaprolactone/Amniotic Membrane Electrospun Nanofiber Scaffolds for Wound Healing

    SEM and MTT assays showed significant cellular proliferation and viability on the proposed scaffolds, and these analyses illustrated that higher cell survival and adhesion could be achieved when scaffolds possessed a larger amount of amniotic membrane.
    [Artificial Organs]

    Abstract

    Synovial Mesenchymal Stem Cell-Derived Exosomal MicroRNA-320c Facilitates Cartilage Damage Repair by Targeting ADAM19-Dependent Wnt Signaling in Osteoarthritis Rats

    After four weeks of destabilization of the medial meniscus surgery to establish an osteoarthritis model, the rats received weekly articular cavity injection of synovial MSCs with or without GW4869 treatment or exosomes from SMSCs with or without microRNA-320c overexpression for another four weeks.
    [Inflammopharmacology]

    Abstract

    Exosomes from CD133+ Human Urine-Derived Stem Cells Combined Adhesive Hydrogel Facilitate Rotator Cuff Healing by Mediating Bone Marrow Mesenchymal Stem Cells

    In vivo experiments were performed by local injection of exosome–hydrogel complexes for the treatment of rotator cuff (RC) injury. The effects of CD133+ urine-derived stem cells-derived exosomes (USC-exos) and USC-Exos on RC healing were assessed from imaging, histological, and biomechanical tests.
    [Journal Of Orthopaedic Translation]

    Full ArticleGraphical Abstract

    Application of Functionalized Hyaluronic Acid Hydrogel with the Activity of Regulating the Behaviors of Stem Cells in Repairing Rabbit Knee Articular Cartilage

    Hyaluronic acid hydrogels containing the system of sustained-release Kartogenin and modified by RGD and HAV peptides were used to facilitate repair of cartilage defect in the knee joint of rabbits.
    [Journal Of Biomaterials Applications]

    AbstractGraphical Abstract
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    REVIEWS

    Current Progress of Mesenchymal Stem Cell Membrane-Camouflaged Nanoparticles for Targeted Therapy

    Investigators review recent progress on the use of MSC membrane-coated nanoparticles for therapy and drug delivery, aiming to provide guidance for the design and clinical application of membrane carrier in the future.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    U of T Home to New Hub That Will Strengthen Canada’s Pandemic Preparedness and Increase Biomanufacturing Capacity

    A new national hub focused on enhancing Canada’s ability to respond quickly, effectively and equitably to future pandemics has become a reality with $2 million in funding from the Canada Biomedical Research Fund.
    [University of Toronto]

    Press Release

    Fred Hutch Announces 2023 Harold M. Weintraub Graduate Student Award Recipients

    Fred Hutchinson Cancer Center has announced 12 recipients of the 2023 Harold M. Weintraub Graduate Student Award, which recognizes exceptional achievement in graduate studies in the biological sciences.
    [Fred Hutchinson Cancer Center ]

    Press Release
    FEATURED EVENT

    Innate Immunity: From Innate Sensing to Adaptive Responses

    April 16 – 19, 2023
    Snowbird, Utah, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Faculty Position – Obstetrics and Gynecology

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Scientist – Regenerative Medicine & the ECM

    InVitro Cell Research, LLC – Fort Lee, New Jersey, United States

    Postdoctoral Fellow – Cartilage Regeneration

    University Medical Center Utrecht – Utrecht, Netherlands

    Research Officer – Bioinformatics

    The University of Melbourne – Melbourne, Australia

    Research Assistant – Immunotherapy for Intervertebral Disc Degeneration

    National University of Singapore – Singapore, Singapore

    > See All Jobs

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