Mesenchymal Cell News Volume 15.09 | Mar 14 2023

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    2023-03-14 | MESCN 15.09


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.09 – 14 March, 2023
    TOP STORY

    Intrapericardial Long Non-Coding RNA–Tcf21 Antisense RNA Inducing Demethylation Administration Promotes Cardiac Repair

    Researchers investigated the mechanisms of extracellular vesicle therapy for improving cardiac remodeling and developed a promising treatment addressing myocardial fibrosis.
    [European Heart Journal]

    Full Article
    Graphical Abstract
    PUBLICATIONSRanked by the impact factor of the journal

    Silk Fibroin and Sericin Differentially Potentiate the Paracrine and Regenerative Functions of Stem Cells through Multiomics Analysis

    Scientists employed multiomics to obtain a global view of the cellular processes and pathways of MSCs triggered by silk fibroin and sericin to discern cell–biomaterial interactions at an in-depth, high-throughput molecular level.
    [Advanced Materials]

    Abstract

    Role and Mechanism of a Micro-/Nano-Structured Porous Zirconia Surface in Regulating the Biological Behavior of Bone Marrow Mesenchymal Stem Cells

    Investigators established a distinct micro-/nano-structured porous zirconia through dry-pressing with addition of pore-forming agents followed by hydrofluoric acid etching.
    [ACS Applied Materials & Interfaces]

    AbstractGraphical Abstract

    Cell Circuits between Leukemic Cells and Mesenchymal Stem Cells Block Lymphopoiesis by Activating Lymphotoxin-Beta Receptor Signaling.

    Using mouse models of acute lymphoblastic and myeloblastic leukemias, researchers showed that leukemic cells turn-off lymphopoiesis and erythropoiesis shortly after colonizing the bone marrow.
    [eLife]

    Abstract

    3D Bioprinting of Human Mesenchymal Stem Cells-Laden Hydrogels Incorporating MXene for Spontaneous Osteodifferentiation

    The MXene-incorporated gelatin methacryloyl and hyaluronic acid methacryloyl bioinks were prepared to explore if they have the potential to enable the spontaneous osteodifferentiation of human MSCs (hMSCs) when the hMSCs-laden GelMA/HAMA-MXene bioinks were 3D printed.
    [Heliyon]

    AbstractGraphical Abstract

    Mechanical Force Induces Macrophage-Derived Exosomal UCHL3 Promoting Bone Marrow Mesenchymal Stem Cell Osteogenesis by Targeting SMAD1

    Investigators suggested that mechanical force-induced macrophage-derived exosomal ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCHL3) promotes bone marrow-derived MSCs osteogenesis by targeting mothers against decapentaplegic homologue 1 (SMAD1).
    [Journal Of Nanobiotechnology]

    Full ArticleGraphical Abstract

    Higenamine Promotes Osteogenesis via IQGAP1/SMAD4 Signaling Pathway and Prevents Age- and Estrogen-Dependent Bone Loss in Mice

    Higenamine treatment resulted in an enhanced bone formation and prevented accelerated bone loss on two animal models that mimic spontaneous senile osteoporosis and postmenopausal osteoporosis.
    [Journal Of Bone And Mineral Research]

    Abstract

    Orthotopic Transplantation of Functional Bioengineered Livers in Rats

    Investigators performed the orthotopic transplantation of functional bioengineered livers in rats subjected to complete hepatectomy.
    [ACS Biomaterials Science & Engineering]

    AbstractGraphical Abstract

    Combined Adipose-Derived Mesenchymal Stem Cell and Antibiotic Therapy Can Effectively Treat Periprosthetic Joint Infection in Rats

    The authors investigated the efficacy of combined intravenous adipose-derived stem cells and antibiotic therapy in comparison to antibiotic monotherapy in a methicillin-sensitive Staphylococcus aureus-infected periprosthetic joint infection rat model.
    [Scientific Reports]

    Full Article
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    REVIEWS

    Mesenchymal Stem Cells: Emerging Concepts and Recent Advances in Their Roles in Organismal Homeostasis and Therapy

    Scientists summarize recent advances in the role of MSCs in multiple disease models and provide insights into the mechanisms by which MSCs interact with endogenous stem cells to exert therapeutic effects.
    [Frontiers In Cellular And Infection Microbiology]

    Full Article
    INDUSTRY AND POLICY NEWS

    BioRestorative Therapies to Seek FDA Approval to Expand the Clinical Application of BRTX-100

    BioRestorative Therapies, Inc. announced that it has entered into an agreement with the Bruder Consulting & Venture Group to assist the company in seeking FDA approval for the expansion of the clinical application of BRTX-100.
    [BioRestorative Therapies, Inc. (Globe Newswire)]

    Press Release
    FEATURED EVENT

    EBMT 49th Annual Meeting

    April 23 – 26, 2023
    Paris, France

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    JOB OPPORTUNITIES

    Postdoctoral Scholar – Cell Programming

    University of Southern California – Los Angeles, California, United States

    Research Faculty Position – Obstetrics and Gynecology

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Research Assistant – Immunotherapy for Intervertebral Disc Degeneration

    National University of Singapore – Singapore, Singapore

    Postdoctoral, Student, and Technician Positions – Stem-Immunology

    Harvard Medical School – Boston, Massachusetts, United States

    Associate Professor – Biomedical Engineering

    Khalifa University – Abu Dhabi, United Arab Emirates

    > See All Jobs

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