Mesenchymal Cell News Volume 15.10 | Apr 11 2023

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    2023-04-11 | MESCN 15.10


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.10 – 11 April, 2023
    TOP STORY

    Graded BMP Signaling within Intestinal Crypt Architecture Directs Self-Organization of the Wnt-Secreting Stem Cell Niche

    Investigators showed that mRNA and chromatin profiles of abundant CD81− PDGFRAlo mouse stromal cells resembled those of trophocytes and that both populations provide crucial canonical Wnt ligands.
    [Cell Stem Cell]

    AbstractGraphical Abstract
    Dr. Fabio Rossi discusses the role of mesenchymal stem cells in tissue repair and development.
    PUBLICATIONSRanked by the impact factor of the journal

    Bioinspired Mild Photothermal Effect-Reinforced Multifunctional Fiber Scaffolds Promote Bone Regeneration

    A bioinspired, staged photothermal effect-reinforced multifunctional scaffold was fabricated for bone repair. Uniaxially aligned electrospun polycaprolactone nanofibers were doped with black phosphorus nanosheets to endow the scaffold with excellent near-infrared responsive capability.
    [ACS Nano]

    AbstractGraphical Abstract

    Gingiva-derived Stromal Cells Isolated from Cats Affected with Tooth Resorption Exhibit Increased Apoptosis, Inflammation, and Oxidative Stress while Experiencing Deteriorated Expansion and Anti-Oxidative Defense

    Gingiva-derived MSCs obtained from the gingiva of healthy cats as well as from cats affected by tooth resorption were isolated and characterized.
    [Stem Cell Reviews And Reports]

    AbstractGraphical Abstract

    Evaluation of Preclinical Efficacy of Human Umbilical Cord Mesenchymal Stem Cells in Ankylosing Spondylitis

    Investigators used a combination of bovine proteoglycan and dimethyldioctadecylammonium to establish a mouse model of proteoglycan-induced spondylitis.
    [Frontiers In Immunology]

    Full Article

    KIAA1199 Deficiency Enhances Skeletal Stem Cell Differentiation to Osteoblasts and Promotes Bone Regeneration

    KIAA1199 plasma levels of patients positively correlated with osteoporotic fracture risk and expression levels of KIAA1199 in patient bone marrow stromal cells negatively correlated with their osteogenic differentiation potential.
    [Nature Communications]

    Full Article

    Application of HUC-MSCs in Rat SCI Model

    Female rats were selected and randomly divided into four groups. Hemostatic forceps were used to clamp the spinal cord for one minute to establish the spinal cord injury (SCI) animal model in rats.
    [Asaio Journal]

    Abstract

    FIR-Preconditioning Promotes Akt-mTOR-Exosome Manufacture in Cooperation with MITF to Boost Resilience of Rat Bone Marrow-Derived Stem Cells

    Scientists identified an unexpected route among the expression of MITF, BCL2, mTOR, and exosome in far-infrared irradiation-preconditioned bone marrow-derived stem cells.
    [Heliyon]

    Full Article

    Mesenchymal Stem Cell-Derived Conditioned Medium and Methysergide Give Rise to Crosstalk Inhibition of 5-HT2A and 5-HT7 Receptors in Neuroblastoma Cells

    Human dental pulp-derived stem cells (hDPSCs) used to obtain conditioned medium (CM). Methysergide drug was prepared in CM and applied to neuroblastoma cells.
    [Brain Research]

    Abstract

    SDF-1α Promotes Subchondral Bone Sclerosis and Aggravates Osteoarthritis by Regulating the Proliferation and Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells

    C57BL/6J mice were divided into the following three groups: the sham control, destabilization of the medial meniscus, and AMD3100-treated destabilization of the medial meniscus groups. The mice were sacrificed after two or eight weeks, and samples were collected for histological and immunohistochemical analyses.
    [BMC Musculoskeletal Disorders]

    Full Article
    Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes
    REVIEWS

    Progression of Pre-Rheumatoid Arthritis to Clinical Disease of Joints: Potential Role of Mesenchymal Stem Cells

    There still exists a gap in the early phase of rheumatoid arthritis pathogenesis, i.e., the progression of diseases from the systemic circulation to joints.
    [Life Sciences]

    AbstractGraphical Abstract

    MicroRNAs-Mediated Regulation of the Differentiation of Dental Pulp-Derived Mesenchymal Stem Cells: A Systematic Review and Bioinformatic Analysis

    The findings of this systematic review support the potential application of the specific miRNAs to regulate the directed differentiation of human dental pulp derived-MSCs in the field of regenerative therapies.
    [Current Stem Cell Research & Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    Bailey Recieves Philanthropic Research Grant

    Pitt Pediatrics congratulates Dr. Kelly M. Bailey for her recent awardance of a research grant from the Charlie Landers Foundation through the Children’s Hospital Foundation of Pittsburgh. The philanthropic funding will be allocated for Bailey’s research into the role of galectin-3 in metastatic Ewing sarcoma.
    [University of Pittsburgh]

    Press Release
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    Advances in Cancer Immunotherapy™: A Focus on Pediatric Cancers

    May 3, 2023
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    JOB OPPORTUNITIES

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    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

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    Université de Lausanne – Lausanne, Switzerland

    Specialist – Cell Processing

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Fellow – Glioblastoma

    University of Oklahoma – Oklahoma City, Oklahoma, United States

    Research Fellow – Neuromuscular Disease

    Mayo Clinic – Rochester, Minnesota, United States

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