Mesenchymal Cell News Volume 15.10 | Mar 21 2023

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    2023-03-21 | MESCN 15.10


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.10 – 21 March, 2023
    TOP STORY

    A Single-Cell Census of Mouse Limb Development Identifies Complex Spatiotemporal Dynamics of Skeleton Formation

    In vivo lineage tracing confirmed the role of Msx1 as a marker the naive progenitors and localized the naive progenitors to the outer margin of the limb, along the anterior-posterior axis.
    [Developmental Cell]

    AbstractGraphical Abstract
    Tips to prepare for your next conference or networking event
    PUBLICATIONSRanked by the impact factor of the journal

    Identification of Key Pathways in Zirconia/Dental Pulp Stem Cell Composite Scaffold-Mediated Macrophage Polarization through Transcriptome Sequencing

    DPSCs were seeded onto N-rGO/ZrO2 composite scaffold material, and their proliferation, adhesion, and osteogenic differentiation were evaluated by CCK-8, immunofluorescence staining, ALP staining, and alizarin red staining.
    [Biotechnology and Genetic Engineering Reviews]

    Abstract

    Identification of Molecularly Unique Tumor-Associated Mesenchymal Stromal Cells in Breast Cancer Patients

    The authors identified CD90+ MSCs residing in the tumor microenvironment of patients with invasive breast cancer that exhibit a unique gene expression signature.
    [PLOS One]

    Full Article

    Wnt Signaling from Gli1-Expressing Apical Stem/Progenitor Cells Is Essential for the Coordination of Tooth Root Development

    Loss of Wnt production in Gli1+ apical stem/progenitor cells led to loss of Axin2 at the root apex, mis-regulation of SOX9, loss of BMP and Hh signaling, and truncation of root development. In the absence of Wnt signals, the root epithelium lost its integrity and epithelial identity.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Exosomes Derived From Kartogenin-Preconditioned Mesenchymal Stem Cells Promote Cartilage Formation and Collagen Maturation for Enthesis Regeneration in a Rat Model of Chronic Rotator Cuff Tear

    Investigators studied the effect of exosomes derived from kartogenin-preconditioned human bone marrow mesenchymal stem cells on tendon-to-bone healing in a rat model of chronic RCT.
    [American Journal of Sports Medicine]

    Abstract

    Rapid and Effective Preparation of Clonal Bone Marrow-Derived Mesenchymal Stem/Stromal Cell Sheets to Reduce Renal Fibrosis

    Scientists engineered clonal human bone marrow MSC (cBMSC) sheets in 24 h to provide rapid preparation. They then determined the influence of cBMSC freeze-thawing on both in vitro production of pro-regenerative factors and in vivo ability to reduce renal fibrosis in a rat model compared to freshly harvested cBMSCs.
    [Scientific Reports]

    Full Article

    Unraveling the Limb Regeneration Mechanisms of Polypedates maculatus, a Sub-tropical Frog, by Transcriptomics

    Researchers described the de novo transcriptome of intact limbs and three-day post-amputation blastemas of tadpoles and froglets of the Asian tree frog Polypedates maculatus.
    [BMC Genomics]

    Full Article

    Human Umbilical-Cord-Derived Mesenchymal Stem Cells in Combination with Rapamycin Reduce Cartilage Degradation via Inhibition of the AKT/mTOR Signaling Pathway

    Scientists explored the role of rapamycin combined with human umbilical-cord-derived MSCs in osteoarthritis (OA) rabbits in vivo. OA rabbits received an intra-articular injection of a collagenase solution.
    [Immunopharmacology And Immunotoxicology]

    Abstract

    Neuroprotective Mechanism of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Improving the Phenotype Polarization of Microglia via the PI3K/AKT/Nrf2 Pathway in Vascular Dementia

    Vascular dementia (VaD) rat model was established by bilateral common carotid artery ligation and human umbilical cord MSC-derived extracellular vesicles (EVs) were extracted. VaD rats were injected with EVs through the tail vein.
    [Synapse]

    Abstract
    STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.
    REVIEWS

    Research Trends and Hotspots of Mesenchymal Stromal Cells in Intervertebral Disc Degeneration: A Scientometric Analysis

    Investigators summarize the main research trends, identify current research hotspots, and measure the networks of the contributors and their scientific productivity.
    [Efort Open Reviews]

    Full Article
    INDUSTRY AND POLICY NEWS

    RoosterBio & Repligen Collaborate to Advance Scalable Exosome Bioprocessing

    RoosterBio, Inc. announced that it has selected Repligen Corporation, a life sciences company focused on bioprocessing technology leadership, as a collaboration partner to advance scalable exosome bioprocessing.
    [RoosterBio, Inc.]

    Press Release

    Sarah Peters Named the First Recipient of AADOCR William Butler Fellowship

    The American Association for Dental, Oral, and Craniofacial Research (AADOCR) named Sarah Peters, The Ohio State University, Columbus the 2023 recipient of the new AADOCR William Butler Fellowship.
    [AADOCR]

    Press Release
    FEATURED EVENT

    Cell Culture Engineering XVIII

    April 23 – 28, 2023
    Cancun, Mexico

    > See All Events

    JOB OPPORTUNITIES

    Laboratory Manager – Biomedical Engineering

    Columbia University – New York, New York, United States

    Postdoctoral Scholar – Cell Programming

    University of Southern California – Los Angeles, California, United States

    Research Faculty Position – Obstetrics and Gynecology

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Research Assistant – Immunotherapy for Intervertebral Disc Degeneration

    National University of Singapore – Singapore, Singapore

    Laboratory Manager – Biomedical Engineering

    Columbia University – New York, New York, United States/p>

    > See All Jobs

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