 | | Vol. 15.11 – 18 April, 2023 |
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| Investigators reported a decrease in bone mineral density in 25% of WHIM patients and bone defects leading to osteoporosis in a WHIM mouse model.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| MSCs lacking p53 showed changes in stem cell properties, including differentiation, cell cycle progression, and metabolism. The transcriptomic changes and genetic mutations in murine p53-deficient undifferentiated soft tissue sarcoma mimicked those seen in human soft tissue sarcomas.
[Stem Cell Reports] |
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| The authors used label-free two-photon excited fluorescence and second harmonic generation imaging to assess cellular and extracellular matrix features of murine articular cartilage during several time points at early stages of osteoarthritis development following destabilization of medial meniscus surgery.
[Communications Biology] |
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| Scientists reported a strategy to generate induced MSCs by directly reprogramming human peripheral blood mononuclear cells with OCT4, SOX9, MYC, KLF4, and BCL-XL using a nonintegrating episomal vector system.
[Communications Biology] |
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| The authors examined the effect of a novel histone deacetylases (HDAC)2&3-selective inhibitor, MI192, on human adipose-derived stem cells epigenetic reprogramming for regulating its osteogenic potential in vitro.
[Bioscience Reports] |
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| Researchers investigated the anti-inflammatory effect of Wharton’s jelly MSCs derived exosomes in combination with metformin in the HepG2 cells insulin resistance model induced by high glucose.
[Heliyon] |
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| Investigators showed that senescent cells could enhance newt limb regeneration. Through a lineage tracing approach, investigators demonstrated that exogenously derived senescent cells promoted dedifferentiation of mature muscle tissue to generate regenerative progenitors.
[Aging Cell] |
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| Researchers established a clonally expanded and immortalized human MSC line and compared the neuroprotective potential of their EVs with EVs from primary MSCs in a murine model of hypoxia–ischemia-induced brain injury.
[Inflammation And Regeneration] |
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| The authors established a clonally expanded and immortalized human MSC line and compared the neuroprotective potential of their EVs with EVs from primary MSCs in a murine model of hypoxia–ischemia-induced brain injury.
[Inflammation And Regeneration] |
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| Several studies have been conducted examining acellular therapy based on MSC secretome. Extracellular vesicles generated by MSCs have been proven to reproduce the impact of MSCs on target cells.
[Communications Biology] |
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| The authors review the recent progress of highly purified skeletal stem cells, their function in bone development and repair, and the impact of aging on skeletal stem cells.
[Osteoporosis International] |
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| Professor Michael Sefton will lead Cell and Engineering Approaches to Preserve and Rejuvenate Organs, one of two projects that have been awarded a total of more than $3 million in Collaborative Research and Training Experience (CREATE) grants from the Natural Science and Engineering Research Council of Canada.
[University of Toronto] |
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| May 9 – 11, 2023
Scottsdale, Arizona, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Universit̩ de Lausanne РLausanne, Switzerland |
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| | Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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| | University of Oklahoma – Oklahoma City, Oklahoma, United States |
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