Mesenchymal Cell News Volume 15.12 | Apr 4 2023

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    2023-04-04 | MESCN 15.12


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.12 – 4 April, 2023
    TOP STORY

    Characterization of Mesenchymal Stem Cells in Human Fetal Bone Marrow by Single-Cell Transcriptomic and Functional Analysis

    The authors reported the expression landscape of human fetal BM nucleated cells (BMNCs) based on the single-cell transcriptomic analysis.
    [Signal Transduction And Targeted Therapy]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Secretive Derived from Hypoxia Preconditioned Mesenchymal Stem Cells Promote Cartilage Regeneration and Mitigate Joint Inflammation via Extracellular Vesicles

    Scientists investigated the paracrine function of the secretome from hypoxia preconditioned mesenchymal stem cells in articular cartilage injury, in comparison to normoxia secretome.
    [Bioactive Materials]

    Full ArticleGraphical Abstract

    Hic1 Identifies a Specialized Mesenchymal Progenitor Population in the Embryonic Limb Responsible for Bone Superstructure Formation

    Researchers showed that a subset of mesenchymal progenitors (MPs), identified by Hic1, do not contribute to the primary cartilaginous anlagen but represent the MP population, whose progeny directly contribute to the interfaces that connect bone to tendon, tendon to muscle, and the associated superstructures.
    [Cell Reports]

    Abstract

    In Vitro Evaluation of Genipin-Crosslinked Gelatin Hydrogels for Vocal Fold Injection

    Some selected formulations were proceeded with rheology, pore size, chemical analysis and in vitro cellular activity of Wharton’s Jelly Mesenchymal Stem Cells, to determine the safety application of the selected hydrogels, for future cell delivery prospect.
    [Scientific Reports]

    Full Article

    3D Bioprinting Using a New Photo-Crosslinking Method for Muscle Tissue Restoration

    Investigators fabricated biofunctional cell-laden structures including methacrylated gelatin, collagen, and decellularized extracellular matrix. In vivo regenerative potential was observed in volumetric muscle defects in a mouse model.
    [NPJ Regenerative Medicine]

    Full Article

    Mesenchymal Stem Cell Aggregation-Released Extracellular Vesicles Induce CD31+EMCN+ Vessels in Skin Regeneration and Improve Diabetic Wound Healing

    The authors identified a specialized vasculature in skin featured by simultaneous CD31 and EMCN expression contributing to the regeneration process, the decline of which functionally underlies the impaired angiogenesis of diabetic non-healing wounds.
    [Advanced Healthcare Materials]

    Abstract

    Evaluation of Preclinical Efficacy of Human Umbilical Cord Mesenchymal Stem Cells in Ankylosing Spondylitis

    Researchers used a combination of bovine proteoglycan and dimethyldioctadecylammonium to establish a mouse model of proteoglycan-induced spondylitis.
    [Frontiers In Immunology]

    Full Article

    WNT7A Suppresses Adipogenesis of Skeletal Muscle Mesenchymal Stem Cells and Fatty Infiltration through the Alternative Wnt-Rho-YAP/TAZ Signaling Axis

    Investigators showed that WNT7A decreased adipogenesis of fibro-adipogenic progenitors (FAPs) by inducing nuclear localization of Yes-associated protein (YAP) through Rho in a β-CATENIN-independent manner.
    [Stem Cell Reports]

    Full Article

    Treatment of Persistent Chemotherapy-Induced Hair Loss (Alopecia) with Human Mesenchymal Stromal Cells Extracellular Enriched Vesicles: A Case Report

    The authors reported successful treatment of a patient suffering from persistent chemotherapy-induced alopecia with extracellular enriched vesicles derived from human placental MSCs.
    [Heliyon]

    Full Article
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    REVIEWS

    Autophagy Is the Key to Making Chronic Wounds Acute in Skin Wound Healing

    Investigators postulate that under favorable conditions autophagy may act as the key modulator of skin wound healing by making chronic wounds acute.
    [Autophagy]

    Full Article
    INDUSTRY AND POLICY NEWS

    Direct Biologics Announces FDA Authorization to Expand Ongoing Phase III Clinical Study of ExoFloâ„¢ to All-Cause Moderate-to-Severe ARDS

    Direct Biologics, LLC announced that the FDA has authorized the expansion of its pivotal Phase III EXTINGUISH ARDS trial to evaluate the safety and efficacy of ExoFloâ„¢ in the treatment of moderate-to-severe acute respiratory distress syndrome (ARDS) from any underlying etiology.
    [Direct Biologics, LLC]

    Press Release

    Inland Empire Stem-Cell Therapy Gets $2.9 Million Booster

    A new UC Riverside training program will help undergraduates transition into regenerative medicine careers, infusing the Inland Empire wraith expertise in cutting-edge trauma and disease treatments.
    [UC Riverside]

    Press Release
    FEATURED EVENT

    Danish Stem Cell Society (DASCS) 2022

    September 19 – 20, 2022
    Vejle, Denmark

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    JOB OPPORTUNITIES

    Research Fellow – Neuromuscular Disease

    Mayo Clinic – Rochester, Minnesota, United States

    Postdoctoral Scholar – Immunotherapy for Glioblastoma

    University of Southern California – Los Angeles, California, United States

    Assistant Professor – Stem Cells and Regenerative Medicine

    Ottawa Hospital Research Institute – Ottawa, Ontario, Canada

    Research Fellow – Stem Cell Biology

    Monash University – Melbourne, Australia

    Postdoctoral Fellowship – Cancer Research and Tumor Immunology

    Ume̴ University РUme̴, Sweden

    > See All Jobs

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