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| Using lineage tracing, investigators demonstrated that a subset of Osr1-expressing cells was mesenchymal lymphoid tissue organizer progenitors.
[Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| By comparing the cell compositions between the alveolar bone and long bone, investigators uncovered a previously undescribed cell population that exhibited a high expression of protocadherin Fat4 and was specifically enriched around alveolar bone marrow cavities.
[Journal Of Dental Research] |
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| The authors designed a novel magnetic-responsive mineralized collagen coating to exert remotely controlled magneto-mechanical stimulation on macrophages using an external magnetic field.
[ACS Biomaterials Science & Engineering] |
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| Guided by computational simulations, scientists evaluated cell and bone-like tissue growth and organization in a concave channel with and without directional fluid flow stimulation.
[Biotechnology And Bioengineering] |
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| The authors compared mesenchymal stromal cells from the large and small intestinal muscle layers. Histological analysis using immunostaining showed that the cells in the large and small intestines were morphologically distinct.
[Biochemistry And Biophysics Reports |
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| Scientists reported on a Phase IIa clinical study that evaluated the impact of local MSC therapy on ulcerative proctitis (UP). 13 refractory UP patients, with an endoscopic Mayo score of 2 or 3, were included.
[JCI Insight] |
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| A newly synthesized nanoplatform of hyaluronic acid and chitosan nanoparticles was applied to improve the therapeutic efficacy and protection of bone marrow MSCs against cisplatin-induced nephrotoxicity in rats.
[International Journal Of Pharmaceutics] |
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| Researchers compared the differences between platelet-rich plasma (PRP)-derived from young and aged donors, and to investigate whether it was possible to enhance the viability of elderly human bone marrow MSCs (hBMSCs) using PRP, and to apply the rejuvenated hBMSCs for the treatment of ischemia.
[European Journal Of Pharmacology] |
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| Scientists used LPS to mimic the microenvironment of peri-implantitis. The osteogenic differentiation of bone-marrow-derived MSCs was assessed by alkaline phosphatase, Alizarin Red S, and mRNA and protein expression of osteogenic-related markers.
[Experimental Cell Research] |
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| The authors discuss the distinct advantages of both MSCs and their secreted exosomes, including their immunomodulatory effects, lack of immunogenicity, and recruitment to damaged areas.
[Expert Opinion On Biological Therapy] |
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| BioCardia®, Inc. announced that the United States Patent Office has granted Patent Number 11,642,377: titled, “ Bone Marrow Derived Neurokinin-1 Receptor Positive (NK1R+) Mesenchymal Stem Cells for Therapeutic Applications”, with a patent term that will expire in 2039.
[BioCardia®, Inc.] |
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| Stempeutics Research, a group company of Manipal Education and Medical Group, announced that enrollment has completed in the Phase III clinical trial evaluating a single peri-ulcer injection of its proprietary allogeneic mesenchymal stromal cell product candidate Stempeucel®-DFU in patients with Non-Healing DFU.
[Stempeutics Research] |
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| June 14 – 17, 2023
Boston, Massachusetts, United States |
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| | Boehringer Ingelheim – Ingelheim, Germany |
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| | Nanyang Technological University – Singapore, Singapore |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | The Francis Crick Institute – London, England, United Kingdom |
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| | University of Gothenburg – Gothenburg, Sweden |
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