Mesenchymal Cell News Volume 15.15 | Apr 25 2023

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    2023-04-25 | MESCN 15.15


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.15 – 25 April, 2023
    TOP STORY

    The Small and Large Intestine Contain Related Mesenchymal Subsets That Derive from Embryonic Gli1+ Precursors

    Researchers found that the transcriptional profile of similar fibroblast subsets differed markedly between the small intestine and colon suggesting region-specific functions.
    [Nature Communications]

    Full Article
    Five tips for returning to the lab after time off
    PUBLICATIONSRanked by the impact factor of the journal

    Material Stiffness in Cooperation with Macrophage Paracrine Signals Determines the Tenogenic Differentiation of Mesenchymal Stem Cells

    The authors developed polydimethylsiloxane substrates with different stiffnesses, and investigated the tenogenic differentiation of MSCs exposed to different stiffnesses and macrophage paracrine signals.
    [Advanced Science]

    Full Article

    Metabolic Profile of Mesenchymal Stromal Cells and Macrophages in the Presence of Polyethylene Particles in a 3D Model

    Scientists cultured MSCs with/without uncommitted M0 macrophages, and with/without contaminated polyethylene particles in 3D gelatin methacrylate constructs/scaffolds.
    [Stem Cell Research & Therapy]

    Full Article

    Targeting G-Quadruplex Motifs Interferes with Differentiation of Adipose-Derived Mesenchymal Stem Cells

    The authors used human adipose-derived MSCs to address the role of G4 motifs during adipogenic differentiation.
    [Stem Cell Research & Therapy]

    Full Article

    Exosomal microRNA-342-5p Secreted from Adipose-Derived Mesenchymal Stem Cells Mitigates Acute Kidney Injury in Sepsis Mice by Inhibiting TLR9

    Researchers explored the possibility of exosomes secreted by adipose-derived MSCs serving as a carrier for microRNA-342-5p to alleviate sepsis-related acute kidney injury and investigated the possible mechanism.
    [Biological Procedures Online]

    Full ArticleGraphical Abstract

    In Vitro Transdifferentiation Potential of Equine Mesenchymal Stem Cells into Schwann-Like Cells

    The facial nerve of a horse was collected, cut into fragments, and incubated in a cell culture medium for 48 hours. This medium was used to transdifferentiate the MSCs into Schwann-like cells.
    [Stem Cells And Development]

    Abstract

    Single-Cell Analysis of Immune Cells on Gingiva-Derived Mesenchymal Stem Cells in Experimental Autoimmune Uveitis

    Investigators generated a lymph node single-cell transcriptomic atlas of gingiva-derived MSC-treated experimental autoimmune uveitis mice.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    The Efficacy of Bone Marrow Mesenchymal Stem Cells on Rat Intestinal Immune-Function Injured by Ischemia/Reperfusion

    Researchers investigated the efficacy of bone marrow MSCs on the immune function of the intestinal mucosal microenvironment after ischemia/reperfusion injuries.
    [Heliyon]

    Full Article

    Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Reduce Insulin Resistance and Obesity in Mice via the PI3K/AKT Signaling Pathway

    The authors investigated the effect of mouse bone marrow MSC-derived exosomes on high-fat diet obese mice and mature 3T3-L1 adipocyte models of insulin resistance.
    [FEBS Open Bio]

    Abstract
    Virtual Conference Exhibition: Pluripotent Stem Cells
    REVIEWS

    The Critical Role of Apoptosis in Mesenchymal Stromal Cell Therapeutics and Implications in Homeostasis and Normal Tissue Repair

    Scientists summarize the current knowledge on the immunomodulatory and therapeutic properties of MSCs with a focus on MSC apoptosis as a key mechanism to elicit immunosuppression.
    [Cellular & Molecular Immunology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Dr. Matthew Greenblatt Wins Pershing Square Foundation’s Inaugural MIND Prize

    Dr. Matthew Greenblatt has been awarded the Pershing Square Foundation’s Maximizing Innovation in Neuroscience Discovery (MIND) Prize to support his work studying how bone cells may influence Alzheimer’s disease progression.
    [Weill Cornell Medicine]

    Press Release
    FEATURED EVENT

    Balancing Genome Fidelity and Plasticity

    May 4 – 7, 2023
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    JOB OPPORTUNITIES

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    University of Gothenburg – Gothenburg, Sweden

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    City of Hope – Duarte, California, United States

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    The German Cancer Re­search Center – Heidelberg, Germany

    Specialist – Cell Processing

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Faculty Positions – Cancer Research

    Case Western Reserve University – Cleveland, Ohio, United States

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