Mesenchymal Cell News Volume 15.16 | May 2 2023

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    2023-005-02 | MESCN 15.16


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.16 – 2 May, 2023
    TOP STORY

    Bioprinted Constructs That Simulate Nerve–Bone Crosstalk to Improve Microenvironment for Bone Repair

    Investigators confirmed the function and molecular mechanisms of Schwann cell-derived exosomes (SC-exos) on bone regeneration and to propose engineered constructs that simulate SC-mediated nerve–bone crosstalk
    [Bioactive Materials]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Identification of an Adipose Tissue-Resident Pro-Preadipocyte Population

    The authors used scRNA-seq to discover a population of CD31− CD45− cells in the stromal vascular fraction that were distinguished by a specific expression profile.
    [Cell Reports]

    Full ArticlePress Release

    Additive Manufacturing of Barium-Doped Calcium Silicate/Poly-ε-Caprolactone Scaffolds to Activate CaSR and AKT Signaling and Osteogenic Differentiation of Mesenchymal Stem Cells

    3D-printed barium-doped calcium silicate/poly-ε-caprolactone composite scaffolds were fabricated as an alternative strategy for bone tissue engineering to achieve appropriate physicochemical characteristics and stimulate osteogenesis.
    [Journal Of Materials Chemistry B]

    Full Article

    Definitive Endodermal Cells Supply an In Vitro Source of Mesenchymal Stem/Stromal Cells

    Scientists reported that hPSC-derived, SOX17+ definitive endoderm progenitors can further differentiate to cells expressing classic MSC markers, which they named definitive endoderm-derived MSCs.
    [Communications Biology]

    Full Article

    Visceral Mesenchymal Stem Cells from Type II Diabetes Donors Activate Triglycerides Synthesis in Healthy Adipocytes via Metabolites Exchange and Cytokines Secretion

    The authors studied the regulatory role of visceral adipose-derived stem cells from donors with obesity and type 2 diabetes mellitus or normal glucose tolerance on healthy subcutaneous adipose-derived stem cell in the Transwell system.
    [International Journal Of Obesity]

    Abstract

    Optimized Reagents for Immunopotency Assays on Mesenchymal Stromal Cells for Clinical Use

    Investigators described a set of experiments aiming at the definition and validation of reliable biological reagents as a first step towards standardization of a potency assay.
    [Immunologic Research]

    Full Article

    Human Amniotic Mesenchymal Stem Cell-Conditioned Medium Inhibited LPS-Induced Cell Injury and Inflammation by Modulating CD14/TLR4-Mediated Signaling Pathway in Monocytes

    Researchers found that conditioned medium of human amniotic mesenchymal stem cells treatment suppressed lipopolysaccharide-induced activation of MAPK and NF-κB pathways by inhibiting CD14/TLR4 in THP-1 cells.
    [Molecular Immunology]

    Full ArticleGraphical Abstract

    Mesenchymal Stem Cell-Derived Extracellular Vesicles Protect against Abdominal Aortic Aneurysm Formation by Inhibiting NET-Induced Ferroptosis

    The authors examined the role and mechanism of MSC-extacellular vesicles in regulating the development of neutrophil extracellular traps-mediated abdominal aortic aneurysm.
    [Communications Biology]

    Full Article

    Safety and Efficacy of Mesenchymal Stromal Cell Therapy for Multi-Drug-Resistant Acute and Late-Acute Graft-Versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation

    Scientists presented a multicenter study on the safety and efficacy of MSC therapy for patients with steroid-refractory late steroid-refractory acute graft versus host disease (aGvHD) in comparison to those with aGvHD.
    [Annals Of Hematology]

    Abstract

    Adipose-Derived Human Mesenchymal Stem Cells Seeded on Denuded or Stromal Sides of the Amniotic Membrane Improve Angiogenesis and Collagen Remodeling and Accelerate Healing of the Full-Thickness Wound

    Researchers investigated the feasibility and effectiveness of wound healing using decellularized human amniotic membrane (HAM) and stromal HAM in combination with adipose-derived human MSCs.
    [Acta Histochemica]

    AbstractGraphical Abstract
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    REVIEWS

    Common Factors among Three Types of Cells Aged in Mice

    The authors evaluated the expression of differentially expressed genes, proteins, and transcription factors in three different types of cells in mice: antibody-secreting cells, cardiac mesenchymal stromal cells, and skeletal muscle cells.
    [Biogerontology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Ossium Health Awarded $3.46M in Funding from the California Institute of Regenerative Medicine (CIRM) to Advance the Development of OSSM-007 for the Treatment of Steroid-Refractory Acute Graft versus Host Disease (GVHD)

    Ossium Health, Inc. announced that the CIRM has awarded the company a $3.46M Clinical Stage Research Program grant to support the continued clinical development of OSSM-007, Ossium’s interferon-gamma primed mesenchymal stem cell product, for the treatment of steroid-refractory GVHD.
    [Ossium Health, Inc. (Business Wire)]

    Press Release
    FEATURED EVENT

    The 2023 ASCO Annual Meeting

    June 2 – 6, 2023
    Chicago, Illinois, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Cell Therapy Processes

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Training Fellow – Colorectal Cancer

    The Francis Crick Institute – London, England, United Kingdom

    Postdoctoral Fellow – Tumor Biology

    University of Gothenburg – Gothenburg, Sweden

    Postdoctoral Position – Allogeneic Cell Therapy Processes

    Delft University of Technology – Delft, Netherlands

    Faculty Positions – Cancer Research

    Case Western Reserve University – Cleveland, Ohio, United States

    > See All Jobs

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