 | | Vol. 15.18 – 23 May, 2023 |
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| The authors presented photopolymerized hydrogels for expansion microscopy that enabled optical clearance and tunable ×4.6–6.7 homogeneous expansion of not only monolayer cell cultures and tissue sections, but cells embedded within hydrogels.
[Nature Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that the tetrahedral DNA nanoplatform had great potential in inducing the differentiation of human MSCs (hMSCs) into functional hepatocyte-like cells by transferring the liver-specific miR122 to hMSCs efficiently without any extrinsic factors.
[Bioactive Materials] |
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| Investigators found that growth and multipotency of human MSCs were enhanced at the highly adaptive fluid interface.
[Advanced Healthcare Materials] |
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| Researchers evaluated a unique device ‘microlyzer’ for generating stromal-vascular fraction from adipose tissue using a mechanical technique that required minimal intervention.
[Scientific Reports] |
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| MSCs were grown into a collagen-glycosaminoglycan matrix to form a dermis-like tissue sheet, named engineered dermal substitute.
[Tissue Engineering Part A] |
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| Retinal pigment epithelium cells from passages 5–7 were treated with WJMSC-S for 24 hours at 37◦C and subsequently subjected to RNA extraction and cDNA synthesis. Gene expression level was evaluated using real-time PCR in the treated versus control cells.
[Molecular Biology Reports] |
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| Researchers explored the roles of mitochondrial function and reactive oxygen species in regulating the adipogenesis ofMaxillary/mandibular bone marrow-derived MSCs.
[Molecular Biology Reports] |
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| Investigators reported that hexyl 5-aminolevulinate hydrochloride-loaded engineered cytokine-primed MSC-extracellular vesicles with high expression of immune checkpoint molecule programmed death-legend 1 (PD-L1) exerted excellent inflammatory targeting and immunosuppressive effects for type 1 diabetes imaging and therapy.
[Small] |
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| Researchers produced hydroxyapatite-based scaffolds with three types of Triply periodic minimal surfaces (TPMS) microarchitectures, namely Diamond, Gyroid, and Primitive, and compared them to an established Lattice microarchitecture by mechanical testing, 3D-cell culture, and in vivo implantation.
[Tissue Engineering Part A] |
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| Cell culture results demonstrated that exosomes improved the proliferation and differentiation of bone marrow MSCs. Following establishment of a supracondylar femoral bone defect, exosomes, and pTa were implanted into the defect area.
[Molecular Medicine Reports] |
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| The authors describe osteoblastogenesis and osteoclastogenesis as two vital processes for producing mature, active bone cells in the context of interactions between cells and the bone matrix.
[Stem Cell Reviews And Reports] |
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| The US FDA approved Vyjuvek, a herpes-simplex virus type 1 vector-based gene therapy, for the treatment of wounds in patients six months of age and older with dystrophic epidermolysis bullosa with mutation(s) in the collagen type VII alpha 1 chain gene.
[FDA] |
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| The world’s second-ever private astronaut mission to the International Space Station will not only ferry up the first Saudi Arabian woman to go to space but also a first-of-its-kind experiment that will test whether scientists can create induced pluripotent stem cells in microgravity.
[FierceBiotech] |
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| June 25 – 30, 2023
Newry, Maine, United States |
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| | Virginia Tech – Washington, DC, United States |
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| | University of Lausanne – Lausanne, Switzerland |
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| | University of Lausanne – Lausanne, Switzerland |
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| | Boehringer Ingelheim – Ingelheim, Germany |
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| | Nanyang Technological University – Singapore, Singapore |
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