Mesenchymal Cell News Volume 15.19 | May 30 2023

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    2023-05-30 | MESCN 15.19


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.19 – 30 May, 2023
    TOP STORY

    Establishment of Gastrointestinal Assembloids to Study the Interplay between Epithelial Crypts and Their Mesenchymal Niche

    The authors established a colon assembloid system comprising the epithelium and diverse stromal cell subtypes.
    [Nature Communications]

    Full Article
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    Impairment of Rigidity Sensing Caused by Mutant TP53 Gain of Function in Osteosarcoma

    Scientists utilized a sphere culture model, a soft agar assay, and soft and rigid hydrogel surface culture models to investigate the function of rigidity sensing in the tumorigenicity of osteosarcoma cells.
    [Bone Research]

    Full Article

    Human Umbilical Cord-Derived Mesenchymal Stem Cells Alleviate Oxidative Stress-Induced Islet Impairment via the Nrf2/HO-1 Axis

    Investigators showed that intravenous injection of human umbilical cord-MSCs engrafted into the injured pancreas and promoted pancreatic β-cell function in a mouse model of type 1 diabetes mellitus.
    [Journal Of Molecular Cell Biology]

    Full ArticleGraphical Abstract

    Rab27a-Mediated Extracellular Vesicle Secretion Contributes to Osteogenesis in Periodontal Ligament-Bone Niche Communication

    The biogenesis of extracellular vesicles from periodontal ligament stem cells was observed using scanning and transmission electron microscopy.
    [Scientific Reports]

    Full Article

    Graphene Quantum Dots Enhance the Osteogenic Differentiation of PDLSCs in the Inflammatory Microenvironment

    Periodontal ligament stem cells were cultured in osteogenic-induced medium with various concentrations of graphene quantum dots in standard medium or medium mimicking a proinflammatory environment.
    [BMC Oral Health]

    Full Article

    Engineering Homologous Platelet-Rich Plasma, Platelet-Rich Plasma-Derived Exosomes, and Mesenchymal Stem Cell-Derived Exosomes-Based Dual-Crosslinked Hydrogels as Bioactive Diabetic Wound Dressings

    The authors developed novel dual-crosslinked hydrogels based on the silk proteins (SPs) sericin and fibroin, including SP@PRP, SP@MSC-Exos, and SP@PRP-Exos, to promote diabetic wound healing synergistically.
    [Bioactive Materials]

    Full ArticleGraphical Abstract

    Stem Cells Therapeutic Effect in a Reserpine-Induced Fibromyalgia Rat Model: A Possible NLRP3 Inflammasome Modulation with Neurogenesis Promotion in the Cerebral Cortex

    Researchers investigated the therapeutic effects of bone marrow MSCs against fibromyalgia-related cerebral cortex damage and the possible underlying mechanisms of action.
    [Life Sciences]

    Abstract

    Human Embryonic Stem Cell-Derived Mesenchymal Stem Cell Secretome Reverts Silica-Induced Airway Epithelial Cell Injury by Regulating Bmi1 Signaling

    Scientists investigated therapeutic effects and potential mechanism of human embryonic stem cell (hESC)-derived MSC-likes immune and matrix regulatory cells, a type of manufacturable MSCs for clinical application in silicosis mice.
    [Environmental Toxicology]

    Abstract

    Comparison of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, and Umbilical Cord Tissue in Regeneration of a Full-Thickness Tendon Defect In Vitro and In Vivo

    Researchers evaluated the potential of one marrow-, umbilical cord blood- and umbilical cord-MSC to differentiate into tendon-like cells in tensioned three-dimensional construct using gene and histological analysis.
    [Biochemistry And Biophysics Reports]

    Full Article
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    REVIEWS

    The Role of Fibroblast Growth Factor 7 in Cartilage Development and Diseases

    The authors systematically summarize the recent biological function of FGF7 and its regulatory role on chondrocytes and cartilage diseases, especially through the hot focus of two key molecules, Runx2 and Cx43.
    [Life Sciences]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    CA Stem Cell Agency Boosts Spending amidst State Budget Deficit

    On the table was a nearly half-billion-dollar research plan to develop revolutionary stem cell and genetic treatments for afflictions ranging from cancer to heart disease. The proposed budget boosted spending by 41 percent for 2023-24 over expenditures for the current fiscal year.
    [Capitol Weekly]

    Editorial
    FEATURED EVENT

    Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases

    July 17 – 20, 2023
    Burlington, Vermont, United States

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    JOB OPPORTUNITIES

    Postdoctoral Scientist – Regenerative Medicine

    Cedars-Sinai – Lawndale, California

    Postdoctoral Associate – Chromatin Mechanisms

    Virginia Tech – Washington, DC, United States

    PhD Position – Tumor Tissue Engineering

    Universit̩ de Lausanne РLausanne, Switzerland

    Postdoctoral Position – Tumor Tissue Engineering

    University of Lausanne – Lausanne, Switzerland

    Research Fellow – Mesenchymal Stem Cells

    Nanyang Technological University – Singapore, Singapore

    > See All Jobs

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