 | | Vol. 15.20 – 6 June, 2023 |
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| The authors identified Cullin 4B as a critical regulator of MSC commitment. CUL4B was expressed in bone marrow MSCs and downregulated with aging in mice and humans.
[Bone Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | | An in situ crosslinked hybrid, multi-material 3D bioprinting approach was used for the fabrication of hydrogel structures based on an aspiration-extrusion microcapillary method.
[Biofabrication] |
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| Scientists developed a 21 day long-term serum-free culture system for human embryonic stem cell-derived immunity-and-matrix-regulatory cells
[ACS Applied Materials & Interfaces] |
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| Researchers established a replicative senescence model of MSCs by successive passages and compared the phenotypic changes between pre-senescent MSCs (Pre-Sen MSCs) and Sen MSCs, and found that Sen MSCs exhibited a diminished adipogenic and osteogenic differentiation potential.
[Stem Cells And Development] |
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| Investigators evaluated possible alterations in Gaucher disease adipocyte that could contribute to bone complications. MSCs were grown in adipogenic media in order to evaluate expression of differentiation markers as PPAR-γ.
[Molecular Genetics And Metabolism] |
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| To investigate whether the conditioned medium of menstrual blood-derived endometrial stem cell could effectively relieve the symptoms of NPC1, the authors employed the CRISPR-Cas9 technique to successfully create a Npc1 gene knockout N2a cell line.
[Metabolic Brain Disease] |
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| Researchers described novel device capable of delivering a direct current of electric field (EF) stimulation to cells cultured in vitro. This bioreactor was customized to simultaneously apply a direct-current EF to six individual cell culture wells, which reduced the amount of experimental time and minimized cost.
[Biotechniques] |
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| MiRNA-17–92 was found to be highly expressed in MSCs and enriched in MSC-exosomes. Moreover, MSC-Exos promoted the proliferation and migration of human umbilical vein endothelial cells in vitro.
[Tissue And Cell] |
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| The authors hypothesized that integrin α10β1 selected-MSCs could be used to treat a sepsis-induced acute respiratory distress syndrome in a porcine model when administering cells after established injury rather than simultaneously.
[Respiratory Research] |
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| A cranial bone defect model of rats was constructed, and the uman periodontal ligament stem cells (hPDLSCs) with or without Klotho pretreatment were transplanted into the defects.
[Journal Of Orthopaedic Surgery And Research] |
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| MSCs are located in various tissues of the body. These cells exhibit regenerative and reparative properties, which makes them highly valuable for cell-based therapy. Despite this, majority of MSC-related studies remain to be translated for regular clinical use.
[Stem Cell Reviews And Reports] |
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| Nearly $13 million in federal grant funds to study treatments for traumatic brain injury, which kills an average of 190 people and hospitalizes another 600 in the U.S. every day, has been awarded to UTHealth Houston by the Department of Defense’s Office of Congressionally Directed Medical Research Programs
[UTHealth Houston] |
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| July 17 – 20, 2023
Burlington, Vermont, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | University of Toronto – Toronto, Ontario, Canada |
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| | King’s College London – London, England, United Kingdom |
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| | Virginia Tech – Washington, DC, United States |
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| | Université de Lausanne – Lausanne, Switzerland |
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