 | | Vol. 15.21 – 20 June, 2023 |
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| Scientists reported that inhibitor of DNA binding 1 (ID1) was highly expressed in the bone marrow microenvironment (BMM) of AML patients, especially in bone marrow MSCs, and the high expression of ID1 in AML-BMM was induced by BMP6, secreted from AML cells.
[Blood] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that the genetic signature of structural Wnt-regulated adipose tissue cells is present in adult human adipose tissue and adipose tissue developed from human progenitor cells in mice.
[Nature Metabolism] |
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| The biological change of MSCs and the functional change of MSCs on chondrocytes were evaluated under articular inflammatory microenvironment (AIM). The key mediator and mechanism for the AIM impact on MSC therapy were explored via gain- and loss-of-function approaches.
[BMC Medicine] |
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| Acellular melt electrowriting (MEW)-norbornene-modified hyaluronic acid (NorHA) composites or MEW-NorHA composites with encapsulated porcine MSCs and precultured for 28 days were implanted in full-thickness cartilage defects in porcine knees using either bioresorbable pins or fibrin glue.
[International Journal Of Bioprinting] |
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| Investigators performed a series of experiments to clarify the mechanistic link between neonatal uterine blood and/or neonatal endometrium and the development of early-onset endometriosis.
[Reproductive Biology And Endocrinology] |
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| The differentially expressed genes of osteoporotic patients and controls were analyzed using the GEO database, and enrichment analysis of DEmRs was performed.
[Molecular Medicine Reports] |
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| | 50 patients ranging from 25 to 45 years old, with an average age of 32 ± 1.24 years were included. None of them had ever used minoxidil, finasteride, or other drugs to promote hair growth. Healthy hair follicles were extracted from the occipital area and treated to obtain hair follicle MSC suspensions.
[Plastic And Reconstructive Surgery] |
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| Light microscopy, transmission electron microscopy, and immunohistochemistry were used to examine the telocytes (TCs). TCs had a cell body and telopodes which formed 3D networks in the cartilage canals and extended their telopodes to become the foremost cellular elements penetrating the cartilage matrix.
[Microscopy Research And Technique] |
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| To promote the application of intra-articular injection of human umbilical cord (UC)-derived MSCs in treating osteoarthritis, investigators conducted an open-label trial to investigate the safety of repeated intra-articular injections of UC-MSCs.
[BMC Musculoskeletal Disorders] |
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| Scientists showed how changes in the nuclear and cellular morphologies of human MSCs induced by micropillar patterns via contact guidance influenced the conformation of the cells’ chromatin and their osteogenic differentiation in vitro and in vivo.
[Nature Biomedical Engineering] |
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| This meta-analysis indicate that MSC therapy may be effective in relieving pain and improving Oswestry Disability Index significantly in patients with lumbar discogenic pain.
[Frontiers In Bioengineering And Biotechnology] |
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| BioSenic announced the decision to suspend its interventional trial on fracture healing, using the ex-Bone-Therapeutics lead product, ALLOB. This decision follows negative results obtained for the primary endpoint in the exploratory Phase IIb trial, which focused on safety and treatment timing efficacy.
[BioSenic] |
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| September 19, 2023
Virtual |
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| | Fred Hutchinson Cancer Center – Seattle, Washington, United States |
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| | VIB Center for Cancer Biology – Leuven, Belgium |
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| | The Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Virginia Tech – Washington, DC, United States |
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