 | | Vol. 15.22 – 27 June, 2023 |
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| Tumor initiation and growth rates were measured for a spontaneous argininosuccinate synthetase 1 gene (Ass1) knockout murine sarcoma model. Tumor cell lines were generated, and resistance to arginine deprivation therapy was studied in vitro and in vivo.
[Clinical Cancer Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | | Researchers engineered innovative nanoscale beta-tricalcium phosphate-laden gelatin methacryloyl/polycaprolactone photocrosslinkable composite fibrous membranes via electrospinning.
[ACS Applied Materials & Interfaces] |
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| The authors investigated the efficacy and underlying mechanisms of human umbilical cord-derived exosomes in lysyl oxidase-like 2 (LOXL2) inhibition of liver fibrosis. MSC-ex, nonselective LOX inhibitor β-aminopropionitrile, or PBS were administered into carbon tetrachloride-induced fibrotic livers.
[Journal Of Nanobiotechnology] |
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| Investigators established a near-infrared light initiated photothermal stimulus platform, with full bioactivity and high thermal manipulation efficiency. They proved that the thermal activation triggered TRPV1 ion channel opening and Ca2+ influx, which finally promoted neural differentiation of bone marrow MSCs.
[Journal Of Materials Chemistry B] |
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| Phosphatidylinositol 4-phosphate 5-kinase α (PIP5Kα), Merlin, or large tumor suppressor kinase 1 (LATS1) knockout or knockdown cells and transfected cells with them were used. LATS1, YAP, and TAZ activities were measured using biochemical methods and PIP2 levels were evaluated using cell imaging.
[Cell Communication And Signaling] |
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| Researchers investigated the role of miR-141-3p in osteogenic differentiation and underlying mechanisms of iRoot SP-treated human stem cells from the apical papilla (hSCAPs). hSCAPs were extracted from tissue blocks with enzyme digestion and identified.
[International Endodontic Journal] |
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| To advance the understanding of physiological functions of p53 and Mdm2 in BM-MSCs, the authors developed traceable conditional mouse models targeting Mdm2 and/or Trp53 in vivo.
[Cell Death & Disease] |
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| Exosomes were isolated from adipose-derived MSCs culture supernatants by differential ultracentrifugation and their effect on C2C12 cells and HUVECs was assessed by EdU, Transwell, and in vitro tube formation assays separately.
[Journal Of Nanobiotechnology] |
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| Investigators showed in a murine graft-versus-host disease model that MSCs promoted the quantity and maturity of thymic epithelial cells (TECs) as well as elevated the proportion of Aire+ medullary TECs, improving both CD4+CD8+ double-positive thymocytes and thymic Tregs, balancing CD4/CD8 ratio in blood.
[Blood Advances] |
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| Demographic analysis found the highest number of cell therapy trials for COVID-19 was in United States, China, and Iran, with the highest number per capita in Israel, Spain, Iran, Australia, and Sweden. The leading cell types were multipotent MSCs, natural killer cells, and mononuclear cells.
[Frontiers In Immunology] |
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| The Weissman Lab, led by Dr. Irving Weissman, a professor at Stanford University in Pathology and Developmental Biology, will be working directly with Fixstars Solutions starting in July, 2023. Fixstars and Dr. Weissman will collaborate on in-situ sequencing research.
[Fixstars Solutions] |
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| September 20 – 23, 2023
Milan, Italy |
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| | KU Leuven – Leuven, Belgium |
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| | Fred Hutchinson Cancer Center – Seattle, Washington, United States |
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| | The Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Virginia Tech – Washington, DC, United States |
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