 | | Vol. 15.23 – 4 July, 2023 |
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| The authors evaluated the potency of mesenchymal stromal cell secretome components to prevent pulmonary fibrosis development and facilitate fibrosis resolution.
[Experimental & Molecular Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| In absence of disease modifying treatment to stop or even delay hemophilic arthropathy progression, scientists authored the therapeutic potential of MSCs-based therapy.
[Hemasphere] |
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| Researchers confirmed that Paclitaxel was effective on mesothelioma cell proliferation in 2D and 3D in vitro cultures, and that 80,000 mesenchymal stromal cells loaded with Paclitaxel inhibit tumor growth at a higher extent than Paclitaxel alone.
[Biochemical Pharmacology] |
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| Investigators characterized the transcriptomic and genomic mutation profiles of canine soft tissue sarcomas subtypes, by leveraging RNAseq, whole exome sequencing, immunohistochemistry, and drug assays.
[Scientific Reports] |
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| The authors fabricated an electrospun perivascular scaffold from polycaprolactone to support MSC attachment and gradual elution at the arteriovenous fistula’s outflow vein.
[Advanced Healthcare Materials] |
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| Angiogenesis patterns in osteosarcoma were explored in depth in this study to construct a prognostic model called ANGscore and clarify the underlying mechanism involved in the immune microenvironment.
[NPJ Precision Oncology] |
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| Scientists found that the population and migration ability of bone marrow MSCs from adiponectin knockout mice was higher than that of wild type mice due to increased stability of hypoxia inducible factor 1α.
[Cell Communication And Signaling] |
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| Isolated islets were cultured for 48 h with SDF-1. Cytokine-induced apoptosis was measured immediately. Islets from Socs3−/− mice were pre-cultured with exogenous SDF-1 and transplanted underneath the kidney capsule of C57BL/6 mice with streptozotocin-induced diabetes.
[Current Stem Cell Research & Therapy] |
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| An 84-year-old Japanese woman presented with a right intrathoracic mass which was 8 cm in size. CT-guided needle biopsy did not provide a definitive diagnosis. Perioperatively, a mass was found in the right lower lobe of the lung and was suspected to have invaded the chest wall at the sixth–eighth ribs.
[Thoracic Cancer] |
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| A lentiviral vector encoding hepatocyte growth factor was successfully produced via Gateway cloning, which was used to infect adipose-derived mesenchymal stem cell.
[Growth Factors] |
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| Investigators review summarized preclinical experiments with different sources of MSCs and their mechanisms in tendon repair, as well as the limitations of MSCs in current clinical applications and directions that need to be explored in the future.
[International Journal Of Molecular Medicine] |
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| The authors review the molecular mechanisms underlying cytokine release syndrome-induced vascular endothelial injury and discuss potential treatments using MSCs.
[Molecular And Cellular Biochemistry] |
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| Dr. Magdalena Zernicka-Goetz was announced as the recipient of the 2023 Ogawa-Yamanaka Stem Cell Prize by Gladstone Institutes. Zernicka-Goetz is a professor of mammalian development and stem cell biology in at the University of Cambridge.
[Gladstone Institutes] |
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| August 6 – 11, 2023
Newry, Maine, United States |
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| | University of Wisconsin-Madison – Madison, Wisconsin, United States |
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| | Boston University – Boston, Massachusetts, United States |
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| | KU Leuven – Leuven, Belgium |
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| | Fred Hutchinson Cancer Center – Seattle, Washington, United States |
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| | The Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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