 | | Vol. 15.24 – 18 July, 2023 |
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| The effects of pore size on the mechanical characteristics and biodegradation of scaffolds, as well as new bone formation, were investigated using magnesium scaffolds with three different pore sizes, namely, 500, 800, and 1400 μm.
[Bioactive Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators performed flow cytometric analysis of neutrophil uptake by ST2 cells, a murine bone marrow-derived stromal cell line, and in murine primary bone marrow-derived stromal cells.
[Cell Death & Disease] |
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| Researchers evaluated the therapeutic effects of induced pluripotent stem cell derived MSC transplantation on brain injury after ischemia‒reperfusion using a rat transient middle cerebral artery occlusion model and compared its therapeutic efficacy to that of bone marrow MSC.
[Molecular Therapy-Methods & Clinical Development] |
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| Scientists determined metalloproteinases (MMPs)’ action in antler stem cells before and after differentiation into adipo-, osteo-, and chondrocytes and the effect of retinoic acid on modifying MMP action in antler stem cells.
[PLOS One] |
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| Bone marrow stem cells were extracted from jaw bone tissue debris obtained from five subjects undergoing implant restoration. Osteogenic and adipogenic experiments proved cells stemness, and the expression of ALP, RUNX2, and OSX were detected by qPCR and Western blot.
[Regenerative Therapy] |
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| The authors found that ghrelin promoted cardiomyocyte differentiation of adipose tissue-derived MSCs in a concentration‑dependent manner, as shown by increased levels of cardiomyocyte markers GATA binding protein 4, α‑myosin heavy chain, ISL LIM homeobox 1, NK2 homeobox 5 and troponin T2, cardiac type.
[Molecular Medicine Reports] |
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| To identify which cell types are suitable for human dry-preserved cell sheets, scientists compared the intracellular FGF2 levels in seven types of cells reported as cell sheets for clinical use or preclinical studies.
[Biochemistry And Biophysics Reports] |
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| Researchers conducted a comprehensive investigation into the impact of heat stress on MSCs, focusing on their morphology, phenotype, proliferative capacity, and fate determination.
[iScience] |
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| Melatonin molecules and recombinant human nerve growth factor were loaded on the surface and in the core of polycaprolactone/chitosan blended nanofibrous scaffold.
[Regenerative Therapy] |
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| It has been described that MSCs can be activated and present various phenotypes, which could explain the divergence in their action; however, these activation mechanisms and the different phenotypes still need to be well known.
[Tissue Engineering Part B-Reviews] |
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| In October 2020, John Carlisle reported a startling estimate of the number of clinical-trial studies in medical journals that are fake or fatally flawed. For more than 150 trials, Carlisle got access to anonymized individual participant data and judged that 44% of the trials contained at least some flawed data.
[Nature] |
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| October 18 – 21, 2023
EMBL Heidelberg and Virtual |
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| | Maastritch University – Maastricht, Netherlands |
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| | National University of Singapore – Singapore, Singapore |
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| | Boston University – Boston, Massachusetts, United States |
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| KU Leuven – Leuven, Belgium |
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| Fred Hutchinson Cancer Center – Seattle, Washington, United States |
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