 | | Vol. 15.25 – 25 July, 2023 |
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| The authors constructed a MSC–based nanoengineered platform via the bioconjugation of MSCs and type I collagenase–modified liposomes loaded with nintedanib for treating severe fibrosis.
[Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Optimal conditions for in vitro mRNA engineering of MSCs are unknown. Scientists investigated several independent variables: transfection factor, mRNA purification method, and mRNA capping.
[Molecular Therapy] |
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| Researchers found that Max-like protein X (MLX), a member of the Myc-MLX network, was driven by super-enhancers. Upregulation of MLX predicted a poor prognosis in osteosarcoma.
[Cell Death & Disease] |
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| Bone marrow MSCs were induced to differentiate into corneal epithelial cells via direct contact co-culture, and platelet-poor plasma was used to prepare fibrin gels, which were compressed to remove excess liquid and then lyophilized to obtain plasma fibrin membrane.
[Biomaterials Science] |
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| Scientists compared the effectiveness and safety of different culture supplements, either fetal bovine serum or human platelet lysate, on the osteoblastic differentiation potential of MSCs derived from human amniotic fluid under a 3D gelatin scaffold.
[Heliyon] |
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| An RNA-Seq analysis was conducted using trophoblasts that were treated with or without chorionic villus-MSC-conditioned media.
[Heliyon] |
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| Gene-ontology analysis on significantly upregulated genes expressed in granulation tissue biopsies revealed enrichment of several genes involved in processes related to matrix remodeling, collagen deposition, and integrin signaling.
[Clinical Oral Investigations] |
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| The biological effect of PF-127 hydrogel alone and in combination with sodium ascorbyl phosphate on the survival, and migration of cultured human umbilical cord-derived MSCs was assessed by cell viability, apoptosis, and scratch wound assays.
[Scientific Reports] |
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| The authors investigated the hub genes and mechanism regulating the mandibular bone mineral density decrease induced by nasal obstruction. A unilateral nasal obstruction model was established in one-week-old Wistar rats by electrocautery obstruction.
[Journal Of Oral Pathology & Medicine] |
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| | Scientists discuss the use of tissue engineering in osteoarthritis treatment and introduce the concept of a new generation of stem cell-based tissue engineering therapy, including the use of engineering, gene therapy, and gene editing techniques to create knee joint-derived-MSCs.
[Acta Biomaterialia] |
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| Sarcoma announced funding for seven cutting-edge research projects to understand sarcoma better and develop new and better treatments. These projects, which are taking place across the UK, will take Sarcoma UK’s total research commitment for the year 2022-23 to a staggering £1.2 million.
[Sarcoma UK] |
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| BioRestorative Therapies, Inc. announced that the final subject in its BRTX-100 Phase II clinical trial safety cohort has been dosed. Study participants were dosed at a 3:1 ratio with either BRTX-100 or control.
[Barron’s] |
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| Dr. Benjamin A. Nacev, assistant professor of medicine in the Division of Hematology/Oncology, has been named a Damon Runyon Clinical Investigator by the Damon Runyon Cancer Research Foundation. With his mentor, Dr. Jeremy Rich, Dr. Nacev will receive $600,000 over three years.
[University of Pittsburgh] |
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| September 22 – 24, 2023
Ribeirao Preto, Brazil |
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| | University of Cincinnati – Cincinnati, Ohio, United States |
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| | Maastritch University – Maastricht, Netherlands |
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| | National University of Singapore – Singapore, Singapore |
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| | Boston University – Boston, Massachusetts, United States |
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| | KU Leuven – Leuven, Belgium |
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