 | | Vol. 14.19 – 1 August, 2023 |
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| Scientists reported massive acute myeloid leukemia (AML) cell infiltration in the skin in a transplantation-induced MLL-AF9 AML mouse model. These AML cells could regenerate AML after transplantation.
[Journal Of Experimental Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The osteogenic differentiation capacity of the recruited MSCs was assessed in vitro. Results confirmed the sustainable release of SDF-1α from the developed biomaterial promoting the migration and homing of human bone marrow MSCs and human gingival MSCs.
[Frontiers in Dental Medicine] |
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| Researchers reported that NUCKS1 was significantly increased in osteosarcoma. Depletion of NUCKS1 decreased osteosarcoma cell proliferation and metastasis in vivo and in vitro.
[Cell Death & Disease] |
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| Scientists found that glioma-associated-MSCs promoted the expression of CD73, an ectonucleotidase that drove immunosuppressive microenvironment maintenance by generating adenosine, on myeloid-derived suppressor cells through immunosuppressive exosomal miR-21 signaling.
[Journal Of Nanobiotechnology] |
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| The authors employed the combinatorial assay matrix approach, including a panel of well-standardized assays to define the phenotype and functionality of human-donor-derived primary MSCs exposed to the representative xenobiotic Atrazine.
[Frontiers In Immunology] |
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| Biomaterials with Young’s modulus of 64 and 0.2 kPa were selected, and the crosstalk between adipose-derived MSCSs (ADSCs) and macrophages was investigated by means of conditioned medium treatment and cell co-culture, respectively.
[Frontiers In Bioengineering And Biotechnology] |
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| Investigators analyzed mice with a mesenchymal tissue-specific knockout of Esr1. Isl1-driven Cre expression generated Esr1 deletion in the uterine stroma and endometrium.
[Scientific Reports] |
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| Bone MSCs (BMSCs) derived from mice were isolated and cultured, osteogenic and adipogenic assays to study the differentiation ability of BMSCs, and flow cytometry was used to detect the surface marker of the third generation cells.
[Heliyon] |
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| Researchers uncovered the fate of transplanted MSCs and develop targeting strategies that could enhance the therapeutic efficacy of MSC therapy in liver fibrosis. They used human umbilical cord-MSCs as the study object.
[Cell Death Discovery] |
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| In the in vivo section, all types of scaffolds with/without bone marrow-derived stem cells were implanted into rat calvaria bone defects, and potential of bone healing was assessed using imaging, staining, and histomorphometric analyses.
[Scientific Reports] |
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| The authors summarize the status of MSC transplantation in treating liver diseases, focusing on the therapeutic mechanisms, including differentiation into hepatocyte-like cells, immunomodulating function with a variety of immune cells, and facilitation of homing and engraftment.
[Stem Cell Reviews And Reports] |
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| Treatments for blood cancer typically include chemotherapy followed by stem cell transplants to restore healthy blood cells. To make stem cells for such transplants more readily available, scientists in the field of cellular therapeutics are turning to the International Space Station National Laboratory.
[IIS National Laboratory] |
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| The United Kingdom-based conglomerate SRAM & MRAM Group has announced a joint venture with CELLAAX. The strategic collaboration is poised to revolutionise stem cell treatment not only in India but also across multiple regions worldwide.
[SRAM & MRAM Group (BioSpectrum)] |
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| October 4 – 6, 2023
Paris, France |
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| | University of Maryland – College Park, Maryland, United States |
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| | IRB Barcelona – Barcelona, Spain |
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| | University of Cincinnati – Cincinnati, Ohio, United States |
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| | National University of Singapore – Singapore, Singapore |
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| | KU Leuven – Leuven, Belgium |
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