 | | Vol. 15.32 – 15 August, 2023 |
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| MSCs possess robust immunoregulatory functions and are promising therapeutics for inflammatory disorders. Investigators examined whether inflammatory cytokines metabolically reprogrammed MSCs to confer this immunoregulatory capacity.
[Cellular & Molecular Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists developed a co-flow microfluidics-based system for the generation of uniform and size-controllable gelatin-based microcarriers for MSCs expansion and tissue engineering.
[Regenerative Biomaterials] |
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| Investigators showed that human conditioned medium of adipose-derived mesenchymal stem cell suppressed benzalkonium chloride-induced cytotoxicity and inflammation in human corneal epithelial cells.
[Scientific Reports] |
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| Researchers tested the neuroprotective effects of MSC-Exos in vitro on H2O2-induced oxidative damage in BV2 cells. An in vivo SAMP8 rapid senescence mouse model showed that MSC-Exos significantly increased SIRT1 gene expression in senescent mice.
[Scientific Reports] |
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| The authors sought to identify variations in miRNA signatures associated with cultured equine MSC chondrogenic differentiation potential from different donors.
[Stem Cells And Development] |
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| Scientists employed bone MSCs (BMSCs) obtained from healthy donors and simulated hypoxia using CoCl2 stimulation.
[Journal of Oral Rehabilitation] |
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| Researchers used the hair follicle to show that during growth, the mesenchymal niche of the hair follicle, the dermal papilla (DP), was maintained quiescent by the activity of Hdac1 and Hdac2 in the DP that suppressed the expression of cell-cycle genes.
[Nature Communications] |
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| The authors found that lncRNA DGCR5 encoded a 102-amino acid polypeptide, Rac1 inactivated peptide (RP), which promoted the adipogenic differentiation of bone marrow MSCs and aggravated the progression of steroid-induced osteonecrosis of the femoral head (SONFH).
[Cell Reports] |
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| Researchers investigated the functional roles of early induction of Hes1 by bone morphogenic protein 9 (BMP9) in a mouse mesenchymal stem cell line, ST2. Hes1 mRNA was transiently and periodically induced by BMP9 in ST2.
[Journal of Cellular Biochemistry] |
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| Investigators critically assess the current literature on the effects of MSCs and their secretomes on persister bacteria.
[World Journal Of Microbiology & Biotechnology] |
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| Rhabdomyosarcoma is a devastating malignancy; outcomes for patients with high-risk disease are dismal and unlike many pediatric cancers, have not improved over the last 3 decades. Immunotherapy holds great potential for improving outcomes in sarcoma patients.
[Sarcoma Foundation of America] |
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| | Creative Biolabs – New York, New York, United States |
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| | University of Cincinnati – Cincinnati, Ohio, United States |
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| | Center for Excellence in Molecular Cell Science – Shanghai, China |
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| | University of Maryland – College Park, Maryland, United States |
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| | IRB Barcelona – Barcelona, Spain |
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