 | | Vol. 15.33 – 22 August, 2023 |
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| Researchers sought to dissect MSC’s trophic mechanism from their efferocytic mechanisms and determine if the viability of MSCs prior to efferocytosis influenced the resultant phenotype of monocytes.
[Stem Cell Research & Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators examined the influence of donor age, sex and tissue source, on the protein profile of the equine MSC secretome. They used dynamic metabolic labeling with stable isotopes combined with liquid chromatography-tandem mass spectrometry to identify secreted proteins in MSC conditioned media.
[Stem Cells] |
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| Researchers tested the neuroprotective effects of MSC-Exos in vitro on H2O2-induced oxidative damage in BV2 cells. An in vivo SAMP8 rapid senescence mouse model showed that MSC-Exos significantly increased SIRT1 gene expression in senescent mice.
[Scientific Reports] |
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| The authors analyzed the expression levels of 47,000 transcripts in adipose-derived, bone marrow-derived, and tonsil-derived MSCs using GeneChip.
[Tissue Engineering And Regenerative Medicine] |
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| Peritoneal mesenchymal stromal cells were grown in plastic dishes for 4–7 passages, and their cell surface phenotype was examined by staining with a panel of 242 antibodies.
[Human Cell] |
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| Scientists evaluated the cytotoxicity and genotoxicity of graphene oxide synthesized by Hummer’s method and functionalized by different amino acids such as lysine, methionine, aspartate, and tyrosine.
[Heliyon] |
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| The rat steroid-induced osteonecrosis of the femoral head model was constructed, and rat bone marrow mesenchymal stem cells were extracted. Aging-related indicators were detected by SA-β-Gal staining, qRT-PCR, and Western Blot experiments.
[Cellular and Molecular Life Sciences] |
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| Investigators assessed the therapeutic potential of intra-arterially administered interleukin-1 alpha preconditioned MSCs, after experimental cerebral ischemia in mice.
[Journal Of Cerebral Blood Flow And Metabolism] |
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| MSCs were obtained from mice and characterized using flow cytometry and cell differentiation culture methods. Then adult C57BL/6 mice were exposed to endotracheal instillation of bleomycin and concurrently treated with MSCs for reversal models on day 14.
[Scientific Reports] |
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| The authors comprehensively review the involvement of mitochondrial dysfunction in the development of liver disease and how MSCs can target mitochondrial dysfunction.
[Cell Communication and Signaling] |
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| Aegle Therapeutics Corp. announced the first patient has been dosed in Phase I/IIa clinical trial of AGLE-102™ for the treatment of severe second-degree burns.
[Aegle Therapeutics Corp. (PR Newswire)] |
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| September 13 – 15, 2023
Seogwipo, South Korea |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | National Cancer Institute – Bethesda, Maryland, United States |
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| | Creative Biolabs – New York, New York, United States |
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| | Center for Excellence in Molecular Cell Science – Shanghai, China |
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| | University of Maryland – College Park, Maryland, United States |
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