Mesenchymal Cell News Volume 15.34 | Aug 29 2023

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    2023-08-29 | MESCN 15.34


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.34 – 29 August, 2023
    TOP STORY

    Premetastatic Niche Mimicking Bone-On-A-Chip: A Microfluidic Platform to Study Bone Metastasis in Cancer Patients

    Photocrosslinkable gelatin methacrylate was used as a 3D culturing hydrogel to encapsulate cells and circulate tumor culture medium adjacent to the hydrogel to verify the critical role of MSCs and osteoclasts.
    [Small]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Substrate Topographies Modulate the Secretory Activity of Human Bone Marrow Mesenchymal Stem Cells

    The topographical PS-based array was developed using razor printing, polishing, and plasma treatment methods. Bone marrow-derived MSCs from four donors were purchased from RoosterBio and used in co-culture with peripheral blood mononuclear cells.
    [Stem Cell Research & Therapy]

    Full Article

    Knockdown of Long Noncoding RNA SAN Rejuvenates Aged Adipose-Derived Stem Cells via miR-143-3p/ADD3 Axis

    The expression patterns of lncRNA senescence-associated noncoding RNA and miR-143-3p in adipose-derived stem cells obtained from old and young volunteer donors were detected by quantitative polymerase chain reaction.
    [Stem Cell Research & Therapy]

    Full Article

    Enhanced Drug Loading Capacity of Graphene Oxide Nanoparticles by Polyglycerol Hyper Branching and Increasing the Sensitivity of Osteosarcoma Cancer Cells to Doxorubicin

    Doxorubicin electrochemically linked to the surface of pH-sensitive polyhydroxy glycerol-grafted graphene oxide nanoparticles, and its loading capacity, release efficiency, and cytotoxicity was assessed using various molecular tests such as flow cytometry, RT-PCR, MTT, and apoptosis assay.
    [Journal of Drug Delivery Science and Technology]

    AbstractGraphical Abstract

    Enhanced Therapeutic Effects of Mesenchymal Stem Cell-Derived Extracellular Vesicles within Chitosan Hydrogel in the Treatment of Diabetic Foot Ulcers

    Scientists developed a safe and efficient method for the large-scale production of human umbilical cord MSC-derived extracellular vesicles while establishing a comprehensive identification protocol encompassing morphology, particle size distribution, protein expression, and purity.
    [Journal Of Materials Science-Materials In Medicine]

    Full ArticleGraphical Abstract

    Characteristics of Mesenchymal Stem Cells and Their Exosomes Derived from Giant Panda (Ailuropoda melanoleuca) Endometrium

    Investigators isolated MSCs from the endometrium of giant panda. RNA-seq analysis showed that 833 genes were upregulated and 716 genes were downregulated in endometrial MSCs compared with skin fibroblast cells.
    [In Vitro Cellular & Developmental Biology – Animal]

    Abstract

    KDM2B-Rearranged Soft-Tissue Sarcomas Expand the Concept of BCOR-Associated Sarcoma

    The authors described three soft tissue sarcomas with KDM2B fusions that phenotypically and epigenetically matched BCOR-associated sarcomas. The cases included one infant, one adolescent, and one older patient.
    [Modern Pathology]

    Abstract

    Human Umbilical Cord Derived Mesenchymal Stem Cells Overexpressing HO-1 Attenuate Neural Injury and Enhance Functional Recovery by Inhibiting Inflammation in Stroke Mice

    The middle cerebral artery occlusion mouse model was established, and subsequent injections of MSC, MSCheme oxygenase-1 (HO-1), or PBS solutions of equal volume were administered via the mice’s tail vein.
    [CNS Neuroscience & Therapeutics]

    Full Article

    Therapeutic Role of Mesenchymal Stem Cells and Platelet-Rich Plasma on Skin Burn Healing and Rejuvenation: A Focus on Scar Regulation, Oxido-Inflammatory Stress, and Apoptotic Mechanisms

    The bone marrow mesenchymal stem cells (BMSCs) and platelet-rich plasma (PRP) were tested on the repair of induced burn wounds in a murine model. After the induction of thermal injury, rats were injected with BMSCs and/or PRP in the burn area.
    [Heliyon]

    Full Article
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    REVIEWS

    The Functional Effects of Piezo Channels in Mesenchymal Stem Cells

    The authors summarize the advances in Piezo channels in MSCs from various tissue sources to provide new ideas for future research and practical applications of Piezo channels and MSCs.
    [Stem Cell Research & Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    US Extends Science Pact with China: What It Means for Research

    The US government has extended for six months a key symbolic agreement to cooperate with China in science and technology.
    [Nature]

    Press Release
    FEATURED EVENT

    Unconventional and Emerging Experimental Organisms in Cell and Developmental Biology

    September 17 – 20, 2023
    Surrey, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Pulmonary Research

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Research Fellow – CDK4/6 Biology and Inhibitor Resistance

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Position – Osteosarcoma

    National Cancer Institute – Bethesda, Maryland, United States

    Postdoctoral Research Fellow – Pathology

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    > See All Jobs

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