Mesenchymal Cell News Volume 15.35 | Sep 5 2023

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    2023-09-05 | MESCN 15.35


    Mesenchymal Cell News by STEMCELL Technologies
    Vol. 15.35 – 5 September, 2023
    TOP STORY

    Surface-Tethered ROS-Responsive Micelle Backpacks for Boosting Mesenchymal Stem Cell Vitality and Modulating Inflammation in Ischemic Stroke Treatment

    Using bioorthogonal click chemistry, reactive oxygen species (ROS)-responsive luteolin-loaded micelles were tethered to the surface of MSCs.
    [Journal of Controlled Release]

    AbstractGraphical Abstract
    Maximize Post-Thaw Cell Recovery with cGMP-Manufactured Cryopreservation Media. Learn More.
    PUBLICATIONSRanked by the impact factor of the journal

    Tensin-3 Is Involved in Osteogenic versus Adipogenic Fate of Human Bone Marrow Stromal Cells

    Researchers linked the domain structure in tensin-3 (TNS3) to RhoA activity via actin dynamics and implicated an important role for TNS3 in regulating osteogenesis and adipogenesis from bone marrow-derived stromal cells.
    [Cellular and Molecular Life Sciences]

    Full Article

    Effect of the Secretome of Mesenchymal Stem Cells Overexpressing BMP-9 on Osteoblast Differentiation and Bone Repair

    The potential of the MSCBMP-9-secretome to induce osteoblast differentiation and bone formation shed lights on novel cell-free-based therapies to promote bone regeneration of challenging defects.
    [Journal of Cellular Physiology]

    Abstract

    Transcriptional Targets of TWIST1 in Human Mesenchymal Stem/Stromal Cells Mechanistically Link Stem/Progenitor and Paracrine Functions

    To define the full spectrum of TWIST1 activity in MSCs, the authors employed integrated omics-based profiling to identify a high confidence set of TWIST1 targets.
    [Stem Cells]

    AbstractGraphical Abstract

    TiO2 Nanotubes Promote Osteogenic Differentiation of Human Bone Marrow Stem Cells via Epigenetic Regulation of RMRP/DLEU2/EZH2 Pathway

    Scientists showed that lncRNA RMRP was upregulated by TiO2 nanotubes to promote osteogenic differentiation through DLEU2/EZH2-mediated epigenetic modifications.
    [Biomedical Materials]

    Abstract

    Vanadium-Doped Mesoporous Bioactive Glass Promotes Osteogenic Differentiation of rBMSCs via the WNT/β-Catenin Signaling Pathway

    A pentavalent vanadium-doped mesoporous bioactive glass was prepared, and its effects on osteogenic differentiation of rat bone marrow MSCs and potential signaling pathways were investigated.
    [ACS Applied Bio Materials]

    AbstractGraphical Abstract

    Local Transplantation of Mesenchymal Stem Cells Improves Encephalo-Myo-Synangiosis-Mediated Collateral Neovascularization in Chronic Brain Ischemia

    Investigators explored whether local transplantation of MSCs in temporal muscle could promote collateral angiogenesis.
    [Stem Cell Research & Therapy]

    Full Article

    Mesenchymal Stem Cells Promote Polarization of M2 Macrophages in Mice with Acute-on-Chronic Liver Failure via Mertk/JAK1/STAT6 Signaling

    Mouse bone marrow-derived MSCs were used to treat an acute-on-chronic liver failure mouse model or cocultured with RAW264.7/J774A.1 macrophages that were stimulated with LPS.
    [Stem Cells]

    AbstractGraphical Abstract

    Total Flavonoids of Rhizoma Drynariae Improves Tendon-Bone Healing for Anterior Cruciate Ligament Reconstruction in Mice and Promotes the Osteogenic Differentiation of Bone Mesenchymal Stem Cells by the ERR1/2-Gga1-TGF-β/MAPK Pathway

    Total flavonoids of Rhizoma drynariae improved tendon-bone healing in anterior cruciate ligament reconstruction mouse models and facilitated the osteogenic differentiation of bone MSCs through the ERR1/2-Gga1-TGF-β/MAPK pathway.
    [Environmental Toxicology]

    Abstract
    Facts above claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    REVIEWS

    Mesenchymal Stem/Stromal Cell-Based Cell-Free Therapy for the Treatment of Acute Lung Injury

    Scientists review MSCs and their therapeutic potential in various diseases, including acute lung injury. They also consider the potential of MSC-based cell-free therapy for future clinical treatment.
    [Journal of Cellular Biochemistry]

    Abstract
    INDUSTRY AND POLICY NEWS

    Stem Cells Used to Successfully Treat Arthritis in Gorilla at Budapest Zoo

    Professor Kiss-Tóth and Professor Wilkinson are now jointly leading a preclinical program to test Stem CellX technologies for the development of a similar stem cell treatment in human patients.
    [University of Sheffield]

    Press Release
    FEATURED EVENT

    AACR Special Conference: Ovarian Cancer

    October 5 – 7, 2023
    Boston, Massachusetts, United States

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    JOB OPPORTUNITIES

    Laboratory Research Scientist – Human Normal and Leukemic Stem Cells

    Francis Crick Institute – London, England, United Kingdom

    Research Associate – Pulmonary Research

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Research Fellow – CDK4/6 Biology and Inhibitor Resistance

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Research Associate – Recombinant Protein

    Creative Biolabs – New York, New York, United States

    > See All Jobs

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