 | | Vol. 15.36 – 12 September, 2023 |
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| Scientists conducted an investigator-initiated, multicenter, single-group, Phase II study of the anti–programmed death ligand 1 agent atezolizumab in adult and pediatric patients with advanced alveolar soft part sarcoma.
[New England Journal Of Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Human MSCs were genetically modified to produce mutant β-galactosidase. Furthermore, a new nitric oxide prodrug, 6-methyl-galactose-benzyl-oxy NONOate, was designed.
[eLife] |
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| EMS affected ASC wells were treated with two different concentrations, 50 and 100 nM, of exogenous SHBG, whose biocompatibility was tested after 24, 48, and 72 h of incubation.
[Cell Communication and Signaling] |
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| Bioinformatics analysis was performed with non-small-cell lung cancer-related miRNA microarray GSE169587 and mRNA data GSE74706 obtained for collection of the differentially expressed miRNAs and mRNAs.
[Journal of Cellular and Molecular Medicine] |
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| Researchers exposed Saos-2 cells to different combinations of ascorbic acid, dexamethasone, and β-glycerophosphate for 14 days and compared the response with immortalized human MSCs.
[Scientific Reports] |
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| The authors coordinated a first-in-kind Phase II clinical trial of the CDK4/6i abemaciclib for patients with progressive dedifferentiated liposarcoma with cellular studies interrogating the molecular basis of geroconversion.
[Clinical Cancer Research] |
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| Investigators confirmed that fibronectin type III domain protein 5 (FNDC5) promoted the survival of transplanted bone marrow MSCs in a rat cerebral infarction model. Bioinformatic analysis and verification experiments revealed the transcription factor, Sp1, to be a key mediator of autophagy regulation by FNDC5.
[Cell Death Discovery] |
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| Researchers reported a case of relapsed DDLPS with a novel in-frame fusion between high-mobility group AT-hook 2 (HMGA2) and KITLG, which encoded the ligand for KIT kinase, a critical protein involved in gametogenesis, hematopoiesis, and melanogenesis.
[Genes Chromosomes & Cancer] |
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| In the past two decades, the therapeutic value of MSCs has been evaluated because of their regenerative potential, which is mainly attributed to the secretion of paracrine factors. Many of these factors are enclosed in extracellular vesicles that reproduce the main functions of parental cells.
[Nature Reviews Rheumatology] |
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| The authors provide a brief description of antler regeneration and the role of antler stem cells (ASCs) and describe the properties and advantages of ASCs.
[Stem Cell Research & Therapy] |
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| Dr. Andrew Kelleher has been awarded a five-year, $2.17 million grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development to study the ability of cells in a woman’s uterine endometrial lining to regenerate in a manner similar to stem cells.
[University of Missouri] |
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| October 11 – 14, 2023
Ottawa, Ontario, Canada |
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| | National Cancer Centre Singapore – Singapore, Singapore |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Creative Biolabs – New York, New York, United States |
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