 | | Vol. 15.38 – 26 September, 2023 |
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| Scientists showed that the ability of SS18-SSX to occupy H2AK119ub1-rich regions was an intrinsic property of its SSX C terminus, which could be exploited by fusion to transcriptional regulators beyond SS18.
[Nature Structural & Molecular Biology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors adapted a previously described engineered bone marrow construct for use as a three-dimensional platform to study how microenvironmental and immune factors affect osteosarcoma tumor progression.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| To achieve mass production and quality control on stem cells and their exosomes, transfecting umbilical cord MSC (UCMSC) with lentivirus overexpressing human telomerase reverse transcriptase (hTERT) gene, the hTERT-UCMSC was constructed as an immortalized MSC cell line.
[Journal of Tissue Engineering] |
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| Investigators explored the role of δ-Tocotrienol in bone marrow-derived MSC ability of wound healing. Transcriptome and single-cell analysis were used to explore the genes and pathways related to ferroptosis in wound tissues.
[Cell Death Discovery] |
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| Researchers comprehensively explored the potential of various types of stem cells from oral cavity as promising therapeutic options in retinal regeneration.
[Stem Cell Reviews And Reports] |
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| The authors demonstrated that cellular heterogeneity could be highly dynamic and dependent on the micromechanical properties of the substrate.
[Scientific Reports] |
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| Using flow cytometry, adipose tissue-derived MSCs were identified, verified, and their conditioned media was used to treat U87 cells. Through RT-qPCR, scratch assay, and apoptosis analysis, scientists evaluated gene expression, cell migration, and apoptosis in U87 cells.
[Tissue and Cell] |
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| | Investigators characterized creeping fat as pro-adipogenic and pro-fibrotic. Lipidomics analysis of Crohn’s disease patients and healthy controls revealed abnormal lipid metabolism in creeping fat.
[Nature Communications] |
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| Scientists investigated the efficacy of human MSCs in high vs low human macrophage migration inhibitory factor (hMIF) environments and the impact of MIF pre-licensing of MSCs using humanized MIF mice in a clinically relevant house dust mite model of allergic asthma.
[Molecular Therapy] |
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| Therapeutic effects of MSCs/MSC-extracellular vesicles in pristane-induced diffuse pulmonary hemorrhage (DPH) mice were evaluated via pulmonary function testing and histopathology. Transcriptome sequencing analyzed differentially expressed genes in control, DPH, and MSC groups.
[Biotechnology Journal] |
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| The authors co-transplanted bone marrow MSCs with Sertoli cell–conditioned medium into the testis of azoospermic mice.
[Reproductive Sciences] |
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| The exosomes (Exos) were extracted by ultracentrifugation and tetramethylpyrazine was loaded into the Exos by electroporation.
[Journal Of Stroke & Cerebrovascular Diseases] |
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| The authors consider the existing evidence regarding the contribution of extracellular matrix-induced intracellular signaling pathways into the regulation of stem cell differentiation, focusing on MSCs as well-studied type of postnatal stem cells totally depended on signals from ECM.
[Cell Communication and Signaling] |
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| Seven members of the UBC Faculty of Medicine are among 48 new Fellows elected into the Canadian Academy of Health Sciences for 2023.
[UBC Faculty of Medicine] |
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| November 1 – 3, 2023
Virtual |
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| | National University of Singapore – Singapore, Singapore |
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| | University of Maryland – College Park, Maryland, United States |
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| | National Cancer Centre Singapore – Singapore, Singapore |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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Cancer Stem Cell News
Cell Therapy News
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Mammary Cell News
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