 | | Vol. 15.39 – 3 October, 2023 |
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| The authors investigated genetically engineered MSCs derived from human bone marrow that continuously secrete stromal-derived factor-1α (SDF1α) .
[Experimental & Molecular Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Three potential assays were examined—assays of apoptosis focusing on caspase activation, assays of phosphatidyl serine externalization on peripheral blood mononuclear cells, and measurement of tumor necrosis factor alpha levels using rapid ELISA methods.
[Frontiers in Immunology] |
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| A competing endogenous RNA regulatory network was obtained through the application of osteoporosis-related high throughput data sets.
[Life Sciences] |
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| Researchers leveraged a methacrylated hyaluronic acid hydrogel platform to study stromal cell mechanotransduction. Hydrogels were first formed through thiol-Michael addition to model normal soft tissue stiffness.
[Macromolecular Bioscience] |
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| Investigators used proteomic analysis to explore the molecules that may contribute to the survival and proliferation of hypoxic preconditioned MSCs.
[Applied Biochemistry and Biotechnology] |
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| | Researchers found that ovariectomized mice exhibited reduced blood vessel density in the bone and reduced expression of the endothelial glycolytic regulator pyruvate kinase M2.
[Advanced Science] |
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| By single-cell RNA sequencing, bone marrow-derived MSCs were the most downregulated cell cluster, and coincidentally, Piezo1 expression was mostly enriched in those cells, and was substantially downregulated by unloading.
[Advanced Science] |
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| The authors employed simultaneous two-step modifications to engineer MSCs and MSC-derived exosomes to create exosomes overexpressing the fused protein lysosome-associated membrane protein 2-interleukin 3 and hematopoietic cell E-selectin/L-selectin ligand.
[Cancer Letters] |
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| Researchers found that administration of antler stem cells improved the survival rate of pulmonary fibrosis mice and reduced lung fibrosis, collagen deposition, and myofibroblast differentiation.
[Cell Death Discovery] |
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| A diabetic cardiomyopathy mouse model was constructed, and the effects of ginsenoside RG1-induced MSCs on myocardial function and fibrosis in diabetic mice were evaluated.
[Phytotherapy Research] |
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| The authors provide a comprehensive overview of the biosynthesis and composition of MSC-derived exosomes and their mechanisms of action in osteoarthritis.
[Cellular & Molecular Biology Letters] |
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| Launched to mark the end of Childhood Cancer Awareness Month, Brain Tumour Research, Leukaemia UK, and Sarcoma UK have formed a pioneering collaboration that is dedicated to funding groundbreaking research into the prevention, treatment and cure of the most common childhood cancers.
[Brain Tumour Research] |
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| October 18 – 21, 2023
EMBL Heidelberg and Virtual |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | National University of Singapore – Singapore, Singapore |
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| | University of Maryland – College Park, Maryland, United States |
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